Exon 6 of human JAG1 encodes a conserved structural unit

January 2009
BMC Structural Biology;2009, Vol. 9, p43
Academic Journal
No abstract available.


Related Articles

  • Differentiated evolutionary rates in alternative exons and the implications for splicing regulation. Plass, Mireya; Eyras, Eduardo // BMC Evolutionary Biology;2006, Vol. 6, p50 

    Background: Alternatively spliced exons play an important role in the diversification of gene function in most metazoans and are highly regulated by conserved motifs in exons and introns. Two contradicting properties have been associated to evolutionary conserved alternative exons: higher...

  • Recognition of Unknown Conserved Alternatively Spliced Exons. Ohler, Uwe; Shomron, Noam; Burge, Christopher B.; Henikoff, Steven // PLoS Computational Biology;Jul2005, Vol. 1 Issue 2, p113 

    The split structure of most mammalian protein-coding genes allows for the potential to produce multiple different mRNA and protein isoforms from a single gene locus through the process of alternative splicing (AS). We propose a computational approach called UNCOVER based on a pair hidden Markov...

  • Genomic Structure of Murine Mitochondrial DNA Polymerase-γ. Mott, Justin L.; Denniger, Grace; Zullo, Steve J.; Zassenhaus, H. Peter // DNA & Cell Biology;Oct2000, Vol. 19 Issue 10, p601 

    We have sequenced a genomic clone of the gene encoding the mouse mitochondrial DNA polymerase. The gene consists of 23 exons, which span approximately 13.2 kb, with exons ranging in size from 53 to 768 bp. All intron-exon boundaries conform to the GT-AG rule. By comparison with the human genomic...

  • Identification of gene-oriented exon orthology between human and mouse. Fu, Gloria C-L; Lin, Wen-chang // BMC Genomics;2012 Supplement, Vol. 13 Issue Suppl 1, p1 

    Background: Gene orthology has been well studied in the evolutionary area and is thought to be an important implication to functional genome annotations. As the accumulation of transcriptomic data, alternative splicing is taken into account in the assignments of gene orthologs and the orthology...

  • Cloning of Mouse Type VII Collagen Reveals Evolutionary Conservation of Functional Protein Domains and Genomic Organization. Kivirikko, Sirpa; Kehua Li, Sirpa; Christiano, Angela M.; Uitto, Jouni // Journal of Investigative Dermatology;Jun96, Vol. 106 Issue 6, p1300 

    Type VII collagen is the major component of anchoring fibrils, attachment structures necessary for stable association of the dermal-epidermal basement membrane to the underlying dermis. The critical role of the anchoring fibrils in providing integrity to the cutaneous basement membrane zone is...

  • Structural and functional analysis of the human TAF1/DYT3 multiple transcript system. Herzfeld, Thilo; Nolte, Dagmar; M�ller, Ulrich // Mammalian Genome;Nov2007, Vol. 18 Issue 11, p787 

    We analyzed TAF1/DYT3, a complex transcript system that is composed of at least 43 exons. Thirty-eight exons code for TATA box binding protein associated factor I (TAF1). Five downstream exons (d1�d5) of yet unknown function can either form transcripts with TAF1 exons or be transcribed...

  • Genomic structure of the gene encoding human 3-hydroxy-3-methyl-glutaryl coenzyme A reductase: comparison of exon/intron organization of sterol-sensing domains among four related genes. Nakajima, T.; Iwaki, K.; Hamakubo, T.; Kodama, T.; Emi, M. // Journal of Human Genetics;2000, Vol. 45 Issue 5, p284 

    Abstract We determined the genomic structure of the human gene encoding 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which catalyzes the conversion of HMG-CoA to mevalonate and is the rate-limiting and major regulatory enzyme in sterol biosynthesis. The gene is more than 21 kb...

  • Structural Organization and Promoter Activity of the Human Ryuddcan Gene1. Takagi, Akira; Kojima, Tetsuhito; Tsuzuki, Shinobu; Katsumi, Akira; Yamazaki, Tomio; Sugiura, Isamu; Hamaguchi, Motohiro; Saito, Hidehiko // Journal of Biochemistry;1996, Vol. 119 Issue 5, p979 

    To better understand the regulation of ryudocan (syndecan-4) expression, we have determined the structural organization of the human ryudocan gene. The human ryudocan gene extends approximately 24 kilobases and is divided into five exons, which appear to be conserved in syndecan family members....

  • Computational discovery of human coding and non-coding transcripts with conserved splice sites. Rose, Dominic; Hiller, Michael; Schutt, Katharina; Hackermüller, Jörg; Backofen, Rolf; Stadler, Peter F. // Bioinformatics;Jul2011, Vol. 27 Issue 14, p1894 

    Motivation: Long non-coding RNAs (lncRNAs) resemble protein-coding mRNAs but do not encode proteins. Most lncRNAs are under lower sequence constraints than protein-coding genes and lack conserved secondary structures, making it hard to predict them computationally.Results: We introduce an...

  • Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome. Schad, Eva; Kalmar, Lajos; Tompal, Peter // Nucleic Acids Research;Apr2013, Vol. 41 Issue 8, p4409 

    A key signature of module exchange in the genome is phase symmetry of exons, suggestive of exon shuffling events that occurred without disrupting translation reading frame. At the protein level, intrinsic structural disorder may be another key element because disordered regions often serve as...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics