TITLE

Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases

PUB. DATE
January 2009
SOURCE
BMC Structural Biology;2009, Vol. 9, p42
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
44172076

 

Related Articles

  • Structural Determinants of the 5′-Methylthioinosine Specificity of Plasmodium Purine Nucleoside Phosphorylase. Donaldson, Teraya M.; Ting, Li-Min; Zhan, Chenyang; Shi, Wuxian; Zheng, Renjian; Almo, Steven C.; Kim, Kami // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

    Plasmodium parasites rely upon purine salvage for survival. Plasmodium purine nucleoside phosphorylase is part of the streamlined Plasmodium purine salvage pathway that leads to the phosphorylysis of both purines and 5′-methylthiopurines, byproducts of polyamine synthesis. We have explored...

  • Single Tryptophan of Disordered Loop from Plasmodium falciparum Purine Nucleoside Phosphorylase: Involvement in Catalysis and Microenvironment. Suthar, Manish; Verma, Anita; Doharey, Pawan; Singh, Shiv; Saxena, Jitendra // Applied Biochemistry & Biotechnology;Jun2013, Vol. 170 Issue 4, p868 

    Among various tropical diseases, malaria is a major life-threatening disease caused by Plasmodium parasite. Plasmodium falciparum is responsible for the deadliest form of malaria, so-called cerebral malaria. Purine nucleoside phosphorylase from P. falciparum is a homohexamer containing single...

  • Targeting Plasmodium Falciparum Purine Salvage Enzymes: A Look At Structure-Based Drug Development. Donaldson, T.; Kim, K. // Infectious Disorders - Drug Targets;Jun2010, Vol. 10 Issue 3, p191 

    New antimalarials are needed due to the rapid development of resistance to currently deployed drugs. Because Plasmodium species are unable to synthesize purines, purine salvage pathways have been proposed as novel anti-malarial targets. The purine salvage pathway in Plasmodium is streamlined...

  • Reply to correspondence letter by Luis Ignacio Gonzalez-Granado. Aytekin, Caner; Dogu, Figen; Ikinciogullari, Aydan // European Journal of Pediatrics;Apr2010, Vol. 169 Issue 4, p519 

    A letter to the editor is presented in response to the article "Purine Nucleoside Phosphorylase Deficiency With Fatal Course in Two Sisters."

  • Disarming the malaria parasite. Engwerda, Christian R.; Good, Michael F. // Nature Medicine;Sep2008, Vol. 14 Issue 9, p912 

    The article focuses on the investigation of the three broad vaccine approaches that target the malaria parasite life cycle. It states that Plasmodium parasites have developed purine pathway in which purine nucleoside phosphorylase (PNP) promotes purine salvage and recycling. It discusses the use...

  • Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model. Cassera, María B.; Hazleton, Keith Z.; Merino, Emilio F.; Obaldia, Nicanor; Ho, Meng-Chiao; Murkin, Andrew S.; DePinto, Richard; Gutierrez, Jemy A.; Almo, Steven C.; Evans, Gary B.; Babu, Yarlagadda S.; Schramm, Vern L. // PLoS ONE;2011, Vol. 6 Issue 11, p1 

    Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed to support combination-therapy approaches promoted by the World Health Organization. Plasmodium species are purine auxotrophs. Blocking...

  • Ethenoguanines Undergo Glycosylation by Nucleoside 2′-Deoxyribosyltransferases at Non-Natural Sites. Ye, Wenjie; Paul, Debamita; Gao, Lina; Seckute, Jolita; Sangaiah, Ramiah; Jayaraj, Karupiah; Zhang, Zhenfa; Kaminski, P. Alexandre; Ealick, Steven E.; Gold, Avram; Ball, Louise M. // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Deoxyribosyl transferases and functionally related purine nucleoside phosphorylases are used extensively for synthesis of non-natural deoxynucleosides as pharmaceuticals or standards for characterizing and quantitating DNA adducts. Hence exploring the conformational tolerance of the active sites...

  • Biosynthesis of nucleoside analogues via thermostable nucleoside phosphorylase. Zhu, Shaozhou; Song, Dawei; Gong, Cuiyu; Tang, Pingwah; Li, Xingzhou; Wang, Jianjun; Zheng, Guojun // Applied Microbiology & Biotechnology;Aug2013, Vol. 97 Issue 15, p6769 

    Biocatalyzed synthesis of nucleoside analogues was carried out using two thermostable nucleoside phosphorylases from the hyperthermophilic aerobic crenarchaeon Aeropyrum pernix K1. The synthesis of the 2,6-diaminopurine nucleoside and 5-methyluridine was used as a reaction model to test the...

  • Structural Bioinformatics Study of PNP from Listeria monocytogenes. Timmers, L. F. S. M.; Caceres, R. A.; Basso, L. A.; Santos, D. S.; De Azevedo Jr., W. F. // Protein & Peptide Letters;Aug2008, Vol. 15 Issue 8, p843 

    This work describes for the first time a model of Purine Nucleoside Phosphorylase from Listeria monocytogenes (LmPNP). We modeled the complexes of LmPNP with ligands in order to determine the structural basis for specificity. Comparative analysis of the model of LmPNP allowed identification of...

  • Nucleotide Metabolism in Plasmodium falciparum: Recent Developments. Raman, Jayalakshmi; Balaram, Hemalatha // Medicinal Chemistry Reviews - Online;Oct2004, Vol. 1 Issue 4, p465 

    Plasmodium falciparum, the causative agent for the most lethal form of malaria, has developed resistance to almost all widely used antimalarials. Availability of the genome sequence with mRNA expression and proteome profiles permit identification of new therapeutic targets, opening up fresh...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics