Long-term exposure to air pollution and hospital admissions for ischemic stroke. A register-based case-control study using modelled NOx as exposure proxy

Oudin, Anna; Stroh, Emilie; Strömberg, Ulf; Jakobsson, Kristina; Björk, Jonas
January 2009
BMC Public Health;2009, Vol. 9 Issue 1, p301
Academic Journal
Background: Long-term exposure to air pollution is a hypothesized risk factor for ischemic stroke. In a large case-control study with a complete study base, we investigated whether hospital admissions for ischemic stroke were associated with residential concentrations of outdoor NOx, as a proxy for exposure to air pollution, in the region of Scania, Southern Sweden. Methods: We used a two-phase case-control study design, including as first-phase controls all individuals born between 1923 and 1965 and residing in Scania in 2002 (N = 556 912). We defined first-phase cases as first-time ischemic stroke patients residing in Scania and registered in the Swedish stroke register between 2001 and 2005 (N = 4 904) and second-phase cases as cases for whom we had information on smoking status, diabetes, and medication for hypertension (N = 4 375). For the controls, information on these covariables was collected from a public health survey, resulting in 4 716 second-phase controls. With a geographical information system and an emission database, individual residential outdoor annual mean NOx concentration was modelled. The data were analyzed with logistic regression. Results: We found no evident association between NOx and ischemic stroke. For example, the odds ratio for ischemic stroke associated with the NOx category 20-30 μg/m³ compared to the reference category of <10 μg/m³ was 0.95 (95% CI 0.86-1.06). Conclusion: In this study area, with generally low levels of air pollution, using a complete study base, high-quality ascertainment of cases, and individually modelled exposure, we did not observe any clear association between NOx and ischemic stroke hospital admissions.


Related Articles

  • Losartan and the meaning of LIFE. Lip, G.Y.H. // Journal of Human Hypertension;May2002, Vol. 16 Issue 5, p289 

    Explores the treatment of hypertension with the use of losartan. Percentage reduction in the incidence of stroke; Reduction in cases of diabetes in patients treated with losartan; Mechanisms leading to the beneficial effects of losartan; Regression of left ventricular hypertrophy.

  • Traffic Trouble: Study Links Diabetes to Vehicular Pollution. Tillett, Tanya // Environmental Health Perspectives;Sep2010, Vol. 118 Issue 9, pA399 

    The article offers information on a study which provides evidence that links the risk of developing type 2 diabetes in women and exposure to traffic-related air pollution.

  • Within- and between-city contrasts in nitrogen dioxide and mortality in 10 Canadian cities; a subset of the Canadian Census Health and Environment Cohort (CanCHEC). Crouse, Dan L; Peters, Paul A; Villeneuve, Paul J; Proux, Marc-Olivier; Shin, Hwashin H; Goldberg, Mark S; Johnson, Markey; Wheeler, Amanda J; Allen, Ryan W; Atari, Dominic Odwa; Jerrett, Michael; Brauer, Michael; Brook, Jeffrey R; Cakmak, Sabit; Burnett, Richard T // Journal of Exposure Science & Environmental Epidemiology;Sep/Oct2015, Vol. 25 Issue 5, p482 

    The independent and joint effects of within- and between-city contrasts in air pollution on mortality have been investigated rarely. To examine the differential effects of between- versus within-city contrasts in pollution exposure, we used both ambient measurements and land use regression...

  • Less clarity as the fog begins to lift. Shah, Anoop S. V.; Newby, David E. // Heart;Jul2014, Vol. 100 Issue 14, p1073 

    The author discusses the adverse health effects of air pollution on cardiovascular disease. He discusses the use of database Myocardial Ischaemia National Audit Project to identify patients admitted for myocardial infarction. He also mentions the role of coronary heart disease, cerebrovascular...

  • Air Pollution and Subtypes, Severity and Vulnerability to Ischemic Stroke—A Population Based Case-Crossover Study. Maheswaran, Ravi; Pearson, Tim; Beevers, Sean D.; Campbell, Michael J.; Wolfe, Charles D. // PLoS ONE;6/30/2016, Vol. 11 Issue 6, p1 

    Background and Purpose: Few studies have examined the association between air pollutants and ischemic stroke subtypes. We examined acute effects of outdoor air pollutants (PM10, NO2, O3, CO, SO2) on subtypes and severity of incident ischemic stroke and investigated if pre-existing risk factors...

  • Community Surveillance of Stroke in Persons under 70 Years Old: Contribution of Uncontrolled Hypertension. Barker, William H.; Feldt, Karen S.; Feibel, John H. // American Journal of Public Health;Mar1983, Vol. 73 Issue 3, p260 

    Abstract: In 1979, a community-wide hospital surveillance system was established in Monroe County, New York (population 702,000), to investigate the continuing contribution of uncontrolled high blood pressure (HBP) to the occurrence o[ stroke. This paper reports findings among 200 consecutive...

  • Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. Llewellyn, David J.; Lang, Iain A.; Matthews, Fiona E.; Plassman, Brenda L.; Rogers, Mary A. M.; Morgenstern, Lewis B.; Fisher, Gwenith G.; Kabeto, Mohammed U.; Langa, Kenneth M. // Alzheimer's Research & Therapy;2010, Vol. 2 Issue 3, p1 

    Introduction: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein ϵ4 (APOE) are associated with dementia. Methods: A population-based sample of 856 individuals aged 71 years or older from all contiguous...

  • Reducing the risk of stroke in type 2 diabetes: pathophysiological and therapeutic perspectives. Sander, Dirk; Kearney, Mark T. // Journal of Neurology;Oct2009, Vol. 256 Issue 10, p1603 

    Reducing the excess cerebrovascular burden in patients with type 2 diabetes remains a major therapeutic challenge, especially with respect to the high risk of recurrent events. Targeting the traditional metabolic risk factors of hypertension, dyslipidemia, and hyperglycemia has failed to remove...

  • Hypertension, Diabetes Are Clues. Dunbar, Mark T. // Review of Optometry;5/15/2010, Vol. 147 Issue 5, p93 

    The article discusses the effect of hypertension and diabetes which leads to the progressive vision loss of one's right eye. It mentions that macroaneurysm (MA) is commonly seen in older individuals and is more likely to be observed in females than in males. It cites some systemic risk factors...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics