TITLE

Long-term exposure to air pollution and hospital admissions for ischemic stroke. A register-based case-control study using modelled NOx as exposure proxy

AUTHOR(S)
Oudin, Anna; Stroh, Emilie; Strömberg, Ulf; Jakobsson, Kristina; Björk, Jonas
PUB. DATE
January 2009
SOURCE
BMC Public Health;2009, Vol. 9 Issue 1, p301
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Long-term exposure to air pollution is a hypothesized risk factor for ischemic stroke. In a large case-control study with a complete study base, we investigated whether hospital admissions for ischemic stroke were associated with residential concentrations of outdoor NOx, as a proxy for exposure to air pollution, in the region of Scania, Southern Sweden. Methods: We used a two-phase case-control study design, including as first-phase controls all individuals born between 1923 and 1965 and residing in Scania in 2002 (N = 556 912). We defined first-phase cases as first-time ischemic stroke patients residing in Scania and registered in the Swedish stroke register between 2001 and 2005 (N = 4 904) and second-phase cases as cases for whom we had information on smoking status, diabetes, and medication for hypertension (N = 4 375). For the controls, information on these covariables was collected from a public health survey, resulting in 4 716 second-phase controls. With a geographical information system and an emission database, individual residential outdoor annual mean NOx concentration was modelled. The data were analyzed with logistic regression. Results: We found no evident association between NOx and ischemic stroke. For example, the odds ratio for ischemic stroke associated with the NOx category 20-30 μg/m³ compared to the reference category of <10 μg/m³ was 0.95 (95% CI 0.86-1.06). Conclusion: In this study area, with generally low levels of air pollution, using a complete study base, high-quality ascertainment of cases, and individually modelled exposure, we did not observe any clear association between NOx and ischemic stroke hospital admissions.
ACCESSION #
44171720

 

Related Articles

  • Perindopril and candesartan comparative efficacy and safety in type II diabetic hypertensive patients. Derosa, G; Cicero, A F G; Mugellini, A; Ciccarelli, L; Fogari, R // Journal of Human Hypertension;Jun2003, Vol. 17 Issue 6, p433 

    Cardiovascular and cerebrovascular disease risks are almost doubled when the hypertensive patient is also affected by diabetes mellitus. Lowering of blood pressure markedly decreases the rate of cardiovascular events and renal deterioration in these patients. The aim of this study is to compare...

  • Awareness of warning signs among suburban Nigerians at high risk for stroke is poor: A cross-sectional study. Wahab, Kolawole W.; Okokhere, Peter O.; Ugheoke, Asuwemhe J.; Oziegbe, Ojeh; Asalu, Adedayo F.; Salami, Taofeek A. // BMC Neurology;2008, Vol. 8, Special section p1 

    Background: Although stroke is a leading cause of morbidity and mortality in Nigeria, there is no information on awareness of its warning signs. This study was designed to assess awareness of stroke warning signs in Nigerians at increased risk. Methods: A hospital-based cross-sectional study...

  • Losartan and the meaning of LIFE. Lip, G.Y.H. // Journal of Human Hypertension;May2002, Vol. 16 Issue 5, p289 

    Explores the treatment of hypertension with the use of losartan. Percentage reduction in the incidence of stroke; Reduction in cases of diabetes in patients treated with losartan; Mechanisms leading to the beneficial effects of losartan; Regression of left ventricular hypertrophy.

  • Stroke of Inspiration. Weinhold, Bob // Environmental Health Perspectives;Feb2002, Vol. 110 Issue 2, pA 92 

    Reports on research findings implicating air pollutants as a contributing factor to strokes. Groups susceptible to stroke due to air pollution; Gases implicated; Data from Seoul, Korea as basis for findings.

  • Effects of Air Pollutants on Acute Stroke Mortality. Hong, Yun-Chul; Lee, Jong-Tae; Kirn, Ho; Ha, Eun-Hee; Schwartz, Joel; Christiani, David C. // Environmental Health Perspectives;Feb2002, Vol. 110 Issue 2, p187 

    The relationship between stroke and air pollution has not been adequately studied. We conducted a time-series study to examine the evidence of an association between air pollutants and stroke over 4 years (January 1995–December 1998) in Seoul, Korea. We used a generalized additive model...

  • Research briefs: Air pollution raises stroke risk.  // GP: General Practitioner;11/4/2005, p5 

    This article presents information on a research which indicates that increased levels of particulate air pollution raises the risk of ischaemic stroke. Researchers looked at the relationship between air quality and hospital admissions for ischaemic stroke over a total of 37,000 hospital days in...

  • Community Surveillance of Stroke in Persons under 70 Years Old: Contribution of Uncontrolled Hypertension. Barker, William H.; Feldt, Karen S.; Feibel, John H. // American Journal of Public Health;Mar1983, Vol. 73 Issue 3, p260 

    Abstract: In 1979, a community-wide hospital surveillance system was established in Monroe County, New York (population 702,000), to investigate the continuing contribution of uncontrolled high blood pressure (HBP) to the occurrence o[ stroke. This paper reports findings among 200 consecutive...

  • Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study. Llewellyn, David J.; Lang, Iain A.; Matthews, Fiona E.; Plassman, Brenda L.; Rogers, Mary A. M.; Morgenstern, Lewis B.; Fisher, Gwenith G.; Kabeto, Mohammed U.; Langa, Kenneth M. // Alzheimer's Research & Therapy;2010, Vol. 2 Issue 3, p1 

    Introduction: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein ϵ4 (APOE) are associated with dementia. Methods: A population-based sample of 856 individuals aged 71 years or older from all contiguous...

  • Reducing the risk of stroke in type 2 diabetes: pathophysiological and therapeutic perspectives. Sander, Dirk; Kearney, Mark T. // Journal of Neurology;Oct2009, Vol. 256 Issue 10, p1603 

    Reducing the excess cerebrovascular burden in patients with type 2 diabetes remains a major therapeutic challenge, especially with respect to the high risk of recurrent events. Targeting the traditional metabolic risk factors of hypertension, dyslipidemia, and hyperglycemia has failed to remove...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics