TITLE

Prevention of Genital Herpes Simplex Virus Type 1 and 2 Disease in Mice Immunized with a gD-Expressing Dominant-Negative Recombinant HSV-1

AUTHOR(S)
Brans, Richard; Akhrameyeva, Natali V.; Feng Yao
PUB. DATE
October 2009
SOURCE
Journal of Investigative Dermatology;Oct2009, Vol. 129 Issue 10, p2470
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
CJ9-gD is a novel herpes simplex virus (HSV) type 1 recombinant virus that is completely replication-defective, expresses high-levels of HSV-1 major antigen glycoprotein D (gD), and can function in trans to inhibit replication of wild-type HSV-1 and HSV-2 in co-infected cells. Here, we show that immunization with CJ9-gD elicits strong and long-lasting humoral and Th1-like cellular immune responses against both HSV-1 and HSV-2. Mice immunized with CJ9-gD exhibited significant reductions in the extent and duration of intravaginal replication of challenge HSV-1 and HSV-2 compared with mock-immunized controls, and were completely protected from local or systemic herpetic disease after intravaginal challenge with wild-type HSV-1 or HSV-2.
ACCESSION #
44151828

 

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