Significance and relationship between Yes-associated protein and survivin expression in gastric carcinoma and precancerous lesions

Chun-Li Da; Yan Xin; Jing Zhao; Xiang-Dong Luo; Rodriguez, Damian Casadesus
August 2009
World Journal of Gastroenterology;8/28/2009, Vol. 15 Issue 32, p4055
Academic Journal
AIM: To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and significance of their expression in gastric carcinoma and precancerous lesions. METHODS: The PV9000 immunohistochemical method was used to detect the expression of YAP and survivin in 98 cases of normal gastric mucosa, 58 intestinal metaplasia (IM), 32 dysplasia and 98 gastric carcinoma. RESULTS: The positive rates of YAP in dysplasia (37.5%) and gastric carcinoma (48.0%) were significantly higher than that in normal gastric mucosa (13.3%), P < 0.01. The positive rates of survivin in IM (53.4%), dysplasia (59.4%) and gastric carcinoma (65.3%) were significantly higher than in normal gastric mucosa (11.2%), P < 0.01. Survivin expression gradually increased from 41.7% in well differentiated adenocarcinoma through 58.3% in moderately differentiated adenocarcinoma to 75.6% in poorly differentiated adenocarcinoma, with significant Rank correlation, rk = 0.279, P < 0.01. The positive rate of survivin in gastric carcinoma of diffused type (74.6%) was significantly higher than that in intestinal type (51.3%), P < 0.05. In gastric carcinoma with lymph node metastasis (76.9%), the positive rate of survivin was significantly higher than that in the group without lymph node metastasis (41.2%), P < 0.01. In 98 cases of gastric carcinoma, the expression of YAP and of survivin were positively correlated, rk = 0.246, P < 0.01.


Related Articles

  • Depressed type of intramucosal differentiated-type gastric cancer has high cell proliferation and reduced apoptosis compared with the elevated type. Nakamura, Toshihiko; Yao, Takashi; Kakeji, Yoshihiro; Anai, Hideaki; Morita, Masaru; Oda, Yoshinao; Maehara, Yoshihiko // Gastric Cancer;Jan2013, Vol. 16 Issue 1, p94 

    Background: The depressed type of early gastric cancer, in comparison to the elevated type, tends to invade the submucosal layer and metastasize to the lymph nodes. This study compared the differences in tumor cell proliferation and apoptosis between the elevated and depressed types of...

  • Δ40 Isoform of p53 Controls β-Cell Proliferation and Glucose Homeostasis in Mice. Hinault, Charlotte; Kawamori, Dan; Chong Wee Liew; Maier, Bernhard; Jiang Hu; Keller, Susanna R.; Mirmira, Raghavendra G.; Scrable, Heidi; Kulkarni, Rohit N. // Diabetes;Apr2011, Vol. 60 Issue 4, p1210 

    OBJECTIVE--Investigating the dynamics of pancreatic β-cell mass is critical for developing strategies to treat both type 1 and type 2 diabetes, p53, a key regulator of the cell cycle and apoptosis, has mostly been a focus of investigation as a tumor suppressor. Although p53 alternative...

  • Immunohistological Analysis of the Jun Family and the Signal Transducers and Activators of Transcription in Thymus. Papoudou-Bai, Alexandra; Barbouti, Alexandra; Galani, Vassiliki; Stefanaki, Kalliopi; Kanavaros, Panagiotis // Anatomy Research International;3/18/2015, Vol. 2015, p1 

    The Jun family and the signal transducers and activators of transcription (STAT) are involved in proliferation and apoptosis. Moreover, c-Jun and STAT3 cooperate to regulate apoptosis. Therefore, we used double immunostaining to investigate the immunotopographical distribution of phospho-c-Jun...

  • The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. Yoshino, H.; Chiyomaru, T.; Enokida, H.; Kawakami, K.; Tatarano, S.; Nishiyama, K.; Nohata, N.; Seki, N.; Nakagawa, M. // British Journal of Cancer;3/1/2011, Vol. 104 Issue 5, p808 

    Background:On the base of the microRNA (miRNA) expression signature of bladder cancer (BC), we found that miR-1 and miR-133a were significantly downregulated in BC. In this study, we focussed on the functional significance of miR-1 and miR-133a in BC cell lines and identified a molecular network...

  • Clinical significance of promoter region hypermethylation of microRNA-148a in gastrointestinal cancers. Jingxu Sun; Yongxi Song; Zhenning Wang; Guoli Wang; Peng Gao; Xiaowan Chen; Zhaohua Gao; Huimian Xu // OncoTargets & Therapy;2014, Vol. 7, p853 

    The aim of this study was to discuss the role of c-KIT mutation in the pathogenesis of gastrointestinal stromal tumors (GISTs) and analyze its correlation with proliferation and apoptosis. c-KIT and PDGFRA genotypes were examined by deoxyribonucleic acid sequencing. Immunohistochemistry was...

  • The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Guevara, Natalia V.; Kim, Han-Seob; Antonova, Ekaterina I.; Chan, Lawrence // Nature Medicine;Mar1999, Vol. 5 Issue 3, p335 

    The tumor suppressor protein p53 is an essential molecule in cell proliferation and programmed cell death (apoptosis), and has been postulated to play a principal part in the development of atherosclerosis. We have examined the effect of p53 inactivation on atherogenesis in apoE-knockout mice,...

  • Leptin regulates proliferation and apoptosis of colorectal carcinoma through PI3K/Akt/mTOR signalling pathway. Wang, Di; Chen, Jian; Chen, Hui; Duan, Zhi; Xu, Qimei; Wei, Meiyan; Wang, Lianghua; Zhong, Meizuo // Journal of Biosciences;Mar2012, Vol. 37 Issue 1, p91 

    Epidemiological studies have indicated that obesity is associated with colorectal cancer. The obesity hormone leptin is considered as a key mediator for cancer development and progression. The present study aims to investigate regulatory effects of leptin on colorectal carcinoma. The expression...

  • P62/Ubiquitin IHC expression correlated with clinicopathologic parameters and outcome in gastrointestinal carcinomas. Amr Mohamed; Ayman, Alkhoder; Deniece, Johnson; Tengteng Wang; Kovach, Charles; Siddiqui, Momin T.; Cohen, Cynthia // Frontiers in Oncology;Mar2015, Vol. 5, p1 

    P62 and ubiquitin are small regulatory proteins demonstrated to have implications in the prognosis and survival of various malignancies including: hepatocellular, breast, ovarian, and some gastrointestinal carcinomas. Several trials studied the link of their activity to the extrinsic apoptosis...

  • Zonal Distribution of Cell Proliferation in the Liver of Untreated B6C3F1 and C57BL Mice. Burkhardt, Silke; Bahnemann, Rainer; Failing, Klaus; Reinacher, Manfred // Toxicologic Pathology;Jan/Feb2004, Vol. 32 Issue 1, p100 

    To determine the lobular distribution of hepatocellular proliferation, S-phase response was measured in untreated adult male B6C3F1 and C57BL mice at ages 11, 14, and 23 weeks. The percentage of cells in S-phase (labeling index, LI) was evaluated using immunohistochemical detection of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics