TITLE

Comparison of penetration depth between two-photon excitation and single-photon excitation in imaging through turbid tissue media

AUTHOR(S)
Gu, Min; Min Gu; Gan, Xiaosong; Xiaosong Gan; Kisteman, Aernout; Xu, Ming Gun; Ming Gun Xu
PUB. DATE
September 2000
SOURCE
Applied Physics Letters;9/4/2000, Vol. 77 Issue 10
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We show, both theoretically and experimentally, that for a turbid tissue medium where Mie scattering is dominant, multiple scattering not only reduces the illumination power in the forward direction but also exhibits an anisotropic distribution of scattered photons. Thus, a signal level under two-photon excitation drops much faster than that under single-photon excitation although image resolution is much higher in the former case. As a result, the penetration depth under two-photon excitation is limited by the strength of two-photon fluorescence and is not necessarily larger than that under single-photon excitation. © 2000 American Institute of Physics.
ACCESSION #
4413115

 

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