TITLE

In Vitro Cytotoxic Properties of Ethanolic Extracts of Various Parts of Swietenia Mahagoni

AUTHOR(S)
Akbar, Mohammad Ahsanul; Ahamed, Rubina; Alam, Khondoker Dedarul; Ali, Mohammad Shawkat
PUB. DATE
June 2009
SOURCE
European Journal of Scientific Research;Jun2009, Vol. 32 Issue 4, p541
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of this study was to investigate cytotoxic properties of the crude ethanolic extracts of seed, bark and leaf of Swietenia mahagoni (Family-Maliaceae) and their various fractions by using brine shrimp lethality bioassay. The seed extract and its dichloromethane and pet-ether fractions exhibited the most significant cytotoxic properties with the LC50 values of 4.68, 4.79 and 6.61 µg/ml, correspondingly. The moderate cytotoxic activities were showed by bark extract, methanol fraction of bark extract, leaf extract and pet-ether fraction of bark extract (LC50 values of 9.54, 10.00, 13.18 and 15.13 µg/ml, respectively) in this experiment. The results in this study are highly promising. Vincristine sulphate (LC50 value of 0.501) was used as positive control in this investigation.
ACCESSION #
44090118

 

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