TITLE

Induction of Diabetes Mellitus in Rats Using Intraperitoneal Streptozotocin: A Comparison between 2 Strains of Rats

AUTHOR(S)
Abeeleh, Mahmoud Abu; Ismail, Zuhair Bani; Alzaben, Khaled R.; Abu-Halaweh, Sami A.; Al-Essa, Mohamed K.; Abuabeeleh, Jaafar; Alsmady, Moaath M.
PUB. DATE
June 2009
SOURCE
European Journal of Scientific Research;Jun2009, Vol. 32 Issue 3, p398
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The purpose of this study was to determine species related differences in the diabetogenic response to streptozotocin (STZ) after single intraperitoneal injection. Twenty adult, male, nude rats (NR, strain Crl:NIH-Fox1RNU) and 8 adult, male Sprague-Dawley (SD) rats were used to induce diabetes using streptozotocin. A single, 150mg/kg STZ was injected intraperitoneally in both strains of rats. Four rats (2 from each strain) were injected buffer and served as control. Severity of the induced diabetic state was assessed by daily monitoring of body weights, clinical signs, and blood glucose levels. Four rats in the NR group died in an average of 5 days following STZ injection and 4 rats of the SD group died in an average of 2 days. In the NR group, non fasting serum glucose levels (267 � 80 mg/dl) rose significantly (P = 0.05) only in 7 (35%) rats while all SD group experienced glucose levels above 300 mg/dl (324 � 20 mg/dl) and required insulin treatment all over the observation period (21 days). It appears that SD rats are far more susceptible to a single intraperitoneal injection of 150mg/kg STZ than NR.
ACCESSION #
44066290

 

Related Articles

  • Effect of rutin on early diabetic neuropathy in experimental animals. Niture, Netaji T.; Patil, Dipak G.; Somani, Rahul S.; Sahane, Rajkumari S. // Journal of Natural Product & Plant Resources;2014, Vol. 4 Issue 4, p1 

    The aim of the present study was to explore the effect of rutin on early diabetic neuropathy in experimental animals. Streptozotocin (55 mg/kg, i.p.) was administered to different groups of rats. Four weeks after injection of streptozotocin, rutin (50 and 100 mg/kg, p.o.), metformin (200 mg/kg,...

  • Antihyperlipidemic Effect of a Polyherbal Mixture in Streptozotocin-Induced Diabetic Rats. Ghorbani, Ahmad; Shafiee-Nick, Reza; Rakhshandeh, Hassan; Borji, Abasalt // Journal of Lipids;2013, p1 

    The effects of a polyherbal mixture containing Allium sativum, Cinnamomum zeylanicum, Citrullus colocynthis, Juglans regia, Nigella sativa, Olea europaea, Punica granatum, Salvia officinalis, Teucrium polium, Trigonella foenum, Urtica dioica, and Vaccinium arctostaphylos were tested on...

  • Scintigraphic evaluation of small intestinal transit in the streptozotocin induced diabetic rats. Durmus-Altun, G.; Vatansever, U.; Arzu, Vardar S.; Altaner, S.; Dirlik, B. // Hippokratia;Jul2011, Vol. 15 Issue 3, p262 

    Aim: Small intestine (SI) transit in the streptozotocin (STZ) induced diabetic rats were examined by using 99mTcmebrofenin scintigraphy. Materials and methods: Wistar albino rats (mean body weight: 220±12 g) were studied for both control (n=10) and diabetes mellitus (DM) (n=10) groups....

  • Effect of Diabetes on Transscleral Delivery of Celecoxib. Narayan Cheruvu; Aniruddha Amrite; Uday Kompella // Pharmaceutical Research;Feb2009, Vol. 26 Issue 2, p404 

    Abstract Purpose  To investigate the effects of diabetes on transscleral retinal delivery of celecoxib in albino and pigmented rats. Methods  Albino (Sprague Dawley—SD) and pigmented (Brown Norway—BN) rats were made diabetic by a single intraperitoneal injection of...

  • Effects of streptozotocin-induced long-term diabetes on parietal cell function and morphology in rats. Bastaki, Salim; Adeghate, Ernest; Chandranath, Irwin; Amir, Naheed; Tariq, Saeed; Hameed, Rashed; Adem, Abdu // Molecular & Cellular Biochemistry;Aug2010, Vol. 341 Issue 1/2, p43 

    Gastric pathology is a common complication in diabetes mellitus. The aim of the study was to evaluate the functions and morphological changes of the parietal cells of the rat stomach after streptozotocin-induced diabetes. Diabetes mellitus was induced in Wistar rats by a single intraperitoneal...

  • Effects of berberine on the expression of AQP-2, IL-1 and IL-6 in a rat model of streptozotocin-induced diabetes mellitus. Guo Zhentao; Zhang Huamin; Zhang Yanfeng; Sun Hongri // HealthMed;2014, Vol. 8 Issue 2, p216 

    Objectives: Berberine, an extract from traditional medicine herbs, has been used for the management of diabetes mellitus (DM) and its complications. The purpose of this study was to detect the effects berberine on the renal function and the expression of aquaporin-2 (AQP-2), interleukin 1 (IL-1)...

  • Microanatomical Study of the Maternal Diabetes Effects on Rat's Choroids Plexus in Embryonic, Neonatal and Adulthood Stages. Tehranipour, M. // Journal of Biological Sciences;2008, Vol. 8 Issue 4, p1199 

    In this research, the effect of maternal diabetes on the choroids plexus volume changes and total length of capillaries in (15°, 1-day-old and 30-day-old) rat neonates was studied. Diabetes was induced by streptozotocin (60 mg kg-1), given by a single intraperitoneal injection to female...

  • Aldose Reductase Inhibitor Ameliorates Renal Vascular Endothelial Growth Factor Expression in Streptozotocin-Induced Diabetic Rats. Joong Kyung Sung; Jang Hyun Koh; Mi Young Lee; Bo Hwan Kim; Soo Min Nam; Jae Hyun Kim; Jin Hee Yoo; So Hee Kim; Sun Won Hong; Eun Young Lee; Ran Choi; Choon Hee Chung // Yonsei Medical Journal;5/1/2010, Vol. 51 Issue 3, p385 

    Purpose: The vascular endothelial growth factor (VEGF) expression of podocyte is one of the well-known major factors in development of diabetic nephropathy. In this study, we investigated the effects of aldose reductase inhibitor, fidarestat on diabetic nephropathy, and renal VEGF expression in...

  • Trend of exogenous bone marrow-derived mesenchymal stem cells in diabetic rats in their migration in vivo to the pancreas and the differentiation into islet cells. XIAO Hong-zhen; ZHANG Hui-qin; LIU Ge-ling // Journal of Chinese Clinical Medicine;2010, Vol. 5 Issue 10, p576 

    To observe the patterns of the directed migration in vivo to the pancreatic tissue in diabetic mellitus(DM) rats via tail vein injection of bone marrow mesenchymal stem cells (BMSCs).Methods 30 female rats were randomly divided into three groups :saline group,BMSCs group and DM model group,n...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics