Clinical and histological features of nonalcoholic fatty liver disease in children

Jae Sung Ko; Jung Min Yoon; Hye Ran Yang; Jae Kyung Myung; Hye Ryeung Kim; Gyeong Hoon Kang; Jung-Eun Cheon; Jeong Kee Seo; Ko, Jae Sung; Yoon, Jung Min; Yang, Hye Ran; Myung, Jae Kyung; Kim, Haeryoung; Kim, Hye Ryeung; Kang, Gyeong Hoon; Cheon, Jung-Eun; Seo, Jeong Kee
October 2009
Digestive Diseases & Sciences;Oct2009, Vol. 54 Issue 10, p2225
Academic Journal
journal article
Background: Nonalcoholic fatty liver disease (NAFLD) is becoming more frequently diagnosed as the prevalence of obesity in children increases rapidly.Aim: The aim of this study was to investigate the correlation of clinical findings with histopathologic features in children with NAFLD.Methods: We reviewed the clinical data and liver histology results of children with biopsy-proven NAFLD at Seoul National University Hospital. NAFLD was classified as simple steatosis, type 1 nonalcoholic steatohepatitis (NASH), characterized by ballooning degeneration and perisinusoidal fibrosis, or type 2 NASH, characterized by portal inflammation and portal fibrosis.Results: Among 80 total patients, 84% were male. All patients were obese or overweight. Insulin resistance was present in 96% of children. Perisinusoidal fibrosis was noted in 45% of children and portal fibrosis was noted in 77%. Simple steatosis was present in 22% of children, type 1 NASH in 34%, and type 2 NASH in 44%. No differences were found among NAFLD subtypes or NAFLD activity score with regard to sex, blood pressure, or levels of aminotransferase, fasting lipid, or insulin. Children with NASH were older and had higher body mass index than those with simple steatosis. Patients with type 2 NASH had higher body mass index and advanced fibrosis compared with patients with type 1 NASH.Conclusions: Obesity and older age are associated with development of NASH. Type 2 NASH is the most common form and associated with a greater severity of obesity and advanced fibrosis.


Related Articles

  • Asymptomatic Abnormal Liver Chemistry - it's all NAFLD. Kassianides, C. // South African Gastroenterology Review;Apr2012, Vol. 10 Issue 1, p32 

    The article discusses the important causes of asymptomatic abnormal liver transaminases and the prevalence of non-alcoholic fatty liver disease (NAFLD). It mentions that NAFLD covers a wide pathologic conditions ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis....

  • Central Portalization Correlates with Fibrosis but Not with Risk Factors for Nonalcoholic Steatohepatitis in Steatotic Chronic Hepatitis C. Lee, Hwajeong; Ainechi, Sanaz; Dresser, Karen; Kurian, Elizabeth M. // International Journal of Hepatology;2014, p1 

    Concomitant steatosis in chronic hepatitis C is associated with fibrosis and unfavorable treatment outcome. Central zone injury in nonalcoholic steatohepatitis (NASH) manifests as central portalization, with centrizonal microvessels and ductular reaction. We investigated whether central...

  • Validation of the BARD scoring system in Polish patients with nonalcoholic fatty liver disease (NAFLD). Raszeja-Wyszomirska, Joanna; Szymanik, Barbara; Lawniczak, Malgorzata; Kajor, Maciej; Chwist, Alina; Milkiewicz, Piotr; Hartleb, Marek // BMC Gastroenterology;2010, Vol. 10, p67 

    Background: Nonalcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver diseases, ranging from pure steatosis to nonalcoholic steatohepatitis (NASH), and eventually to liver cirrhosis with its complications. Identifying advanced fibrosis in patients is crucial to evaluating...

  • The Spontaneous Course of Liver Enzymes and Its Correlation in Nonalcoholic Fatty Liver Disease. Charatcharoenwitthaya, Phunchai; Lindor, Keith; Angulo, Paul // Digestive Diseases & Sciences;Jul2012, Vol. 57 Issue 7, p1925 

    Background: The course of liver enzymes and their clinical correlations in nonalcoholic fatty liver disease (NAFLD) remains largely undescribed. Aims: The objective of this study was to determine the spontaneous course of liver enzymes, and the association between changes in liver enzymes with...

  • Non-alcoholic fatty liver disease: non-invasive investigation and risk stratification. Dyson, J. K.; McPherson, S.; Anstee, Q. M. // Journal of Clinical Pathology;Dec2013, Vol. 66 Issue 12, p1033 

    Non-alcoholic fatty liver disease (NAFLD) encompasses a histological spectrum of liver disease, from simple steatosis through to cirrhosis. As the worldwide rates of obesity have increased, NAFLD has become the commonest cause of liver disease in many developed countries, affecting up to a third...

  • Differential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis during Macrophage Infection. Eskra, Linda; Covert, Jill; Glasner, Jeremy; Splitter, Gary // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Brucella spp. cause chronic zoonotic disease often affecting individuals and animals in impoverished economic or public health conditions; however, these bacteria do not have obvious virulence factors. Restriction of iron availability to pathogens is an effective strategy of host defense. For...

  • Insulin resistance - a key to non-alcoholic fatty liver disease. Raszeja-Wyszomirska, Joanna // Gastroenterologia Polska / Gastroenterology;2009, Vol. 16 Issue 1, p57 

    Nonalcoholic fatty liver disease (NAFLD) covers a wide spectrum of liver pathology - from steatosis alone, through the necroinflammatory disorder of nonalcoholic steatoheatohepatitis (NASH) to cirrhosis and liver cancer. NAFLD is recognized as one of the most frequent reason of liver test...

  • The Role of 13C-Methacetin Breath Test for the Non-Invasive Evaluation of Nonalcoholic Fatty Liver Disease. Fierbinteanu-Braticevici, Carmen; Plesca, Doina-Anca; Tribus, Laura; Panaitescu, Eugenia; Braticevici, Bogdan // Journal of Gastrointestinal & Liver Diseases;Jun2013, Vol. 22 Issue 2, p149 

    Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in many parts of the world. The 13C-methacetin breath test (MBT), a microsomal liver function test, enables quantitative evaluation of cytochrome P450-dependent liver function involved in NAFLD...

  • Performance of Biomarkers FibroTest, ActiTest, SteatoTest, and NashTest in Patients with Severe Obesity: Meta Analysis of Individual Patient Data. Poynard, Thierry; Lassailly, Guillaume; Diaz, Emmanuel; Clement, Karine; Caïazzo, Robert; Tordjman, Joan; Munteanu, Mona; Perazzo, Hugo; Demol, Bernard; Callafe, Robert; Pattou, François; Charlotte, Frederic; Bedossa, Pierre; Mathurin, Philippe; Ratziu, Vlad // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    Background: Liver biopsy is considered as the gold standard for assessing non-alcoholic fatty liver disease (NAFLD) histologic lesions in patients with severe obesity. The aim of this study was to perform an overview of 3 studies which assessed the performance of non-invasive markers of fibrosis...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics