Diminution of Circulating CD4+CD25high T Cells in Naïve Crohn’s Disease

Chamouard, Patrick; Monneaux, Fanny; Richert, Zoe; Voegeli, Anne-Claire; Lavaux, Thomas; Gaub, Marie; Baumann, René; Oudet, Pierre; Muller, Sylviane
October 2009
Digestive Diseases & Sciences;Oct2009, Vol. 54 Issue 10, p2084
Academic Journal
Crohn’s disease is considered to be caused either by an excess of T-cell effector functions and/or by a defective regulatory T-cell compartment. The aim of this study was to assess in Crohn’s disease the frequency of circulating CD4+CD25high T cells that possess regulatory T-cell functions and CD4+CD25low T cells that contain activated T cells. Flow cytometry of peripheral blood was used to assess CD4+CD25high and CD4+CD25low T-cell frequencies in a cohort of 66 patients with Crohn’s disease in comparison to 19 patients with ulcerative colitis and 31 healthy individuals enrolled as controls. The CD4+CD25high T-cell frequency was significantly lowered in naïve Crohn’s disease ( P = 0.013) and in ulcerative colitis ( P = 0.001). CD4+CD25low T-cell frequency was increased in Crohn’s disease ( P = 0.0001) and in ulcerative colitis ( P = 0.0002). Both CD4+CD25high and CD4+CD25low T-cell frequencies are altered in naïve Crohn’s disease resulting in an imbalance between both populations and a relative contraction of the CD4+CD25high T-cell population.


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