TITLE

How I Manage H. Pylori-Negative, NSAID/Aspirin-Negative Peptic Ulcers

AUTHOR(S)
McColl, Kenneth E. L.
PUB. DATE
January 2009
SOURCE
American Journal of Gastroenterology;Jan2009, Vol. 104 Issue 1, p190
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The first and most important action on encountering a patient with unexplained gastric or duodenal ulceration is to double check that they are truly H. pylori negative and also not taking any ulcerogenic medicines. Once the patient is confirmed to be H. pylori negative and NSAID negative, ensure that biopsies of the ulcer—whether gastric or duodenal—and of the surrounding gastric and duodenal mucosa are obtained to exclude underlying malignancy/lymphoma, Crohn's disease, and unusual infectious agents. If the etiology of the ulceration remains unexplained, an underlying gastrinoma should be considered and excluded. Patients with idiopathic ulcers should be maintained on proton pump inhibitor therapy, and higher doses may be required to control acid secretion and prevent ulcer relapse in these H. pylori-uninfected subjects.
ACCESSION #
43984172

 

Related Articles

  • Helicobacter pylori-negative gastric and duodenal ulcers. Tsuji, Hideharu; Kohli, Yoshihiro; Fukumitsu, Shinji; Morita, Kiyoshi; Kaneko, Hiroto; Ohkawara, Tohru; Minami, Masahito; Ueda, Kazushige; Sawa, Yoshihiko; Matsuzaki, Haruki; Morinaga, Osamu; Ohkawara, Yasuo // Journal of Gastroenterology;1999, Vol. 34 Issue 4, p455 

    Abstract: It is unclear whether Helicobacter pylori infection is essential to the development of peptic ulcers. In this study, we examined the rates of H. pylori-negativity among patients with peptic ulcers. We also attempted to clarify the characteristics of H. pylori-negative peptic ulcers to...

  • Childhood ulcers.  // Pediatrics for Parents;1995, Vol. 16 Issue 4, p1 

    Reports on the incidence of peptic ulcers in children. Infection with Helicobacter pylori.

  • Helicobacter pylori Infection and the Risk for Duodenal and Gastric Ulceration. Nomura, Abraham; Stemmermann, Grant N.; Chyou, Po-Huang; Perez-Perez, Guillermo I.; Blaser, Martin J. // Annals of Internal Medicine;6/15/94, Vol. 120 Issue 12, p977 

    Presents information on a study which determined whether a preexisting Helicobacter pylori infection increases the risk for developing duodenal or gastric ulcer. Characteristics of patients with peptic ulcer and controls; Methodology; Results and discussion; Conclusions.

  • Factors Associated with Helicobacter pylori Infection by a cagA-Positive Strain in Children. Queiroz, Dulciene M.M.; Mendes, Edilberto N.; Carvalho, Anfrisina S.T.; Rocha, Gifone A.; Oliveira, Andreia M.R.; Soares, Taciana F.; Santos, Adriana; Cabral, Monica M.D.A.; Nogueira, Ana M.M.F. // Journal of Infectious Diseases;2/1/2000, Vol. 181 Issue 2, p626 

    Studies factors associated with Helicobacter pylori infection by a cagA-positive strain in children. Essential factor in the pathogenesis of duodenal peptic ulcer; Relationship between ulcerogenesis and infection with a cagA-positive Helicobacter pylori strain in children; Characteristics of...

  • The end of the era of maintenance therapy for peptic ulcer disease? Chiba, Tsutomu // Journal of Gastroenterology;2000, Vol. 35 Issue 11, p873 

    Editorial. Suggests that Helicobacter pylori eradication should be considered as the first-line therapy for active peptic ulcer disease, according to a study published in the November 2000 issue of the `Journal of Gastroenterology.'

  • Ulcers and bacteria--the role of H. pylori.  // American Family Physician;11/1/1995, Vol. 52 Issue 6, p1729 

    Cites the role of Helicobacter pylori in the development of peptic ulcers. Importance of treating H. pylori infection; All patients with stomach and duodenal ulcers as needing HH. pylori infection treatment; Antibiotic treatment for H. pylori infection.

  • Bleeding peptic ulcer in Japan: Role of Helicobacter pylori infection and NSAIDs use. Ootani, H.; Kikkawa, A.; Shimoda, R.; Oda, K.; Fujise, T.; Nakahara, S.; Tsunada, S.; Sakata, H.; Iwakiri, R.; Kujimoto, K. // Gut;Sep2002 Supplement 2, Vol. 51, pA64 

    Aim: The aim of this study is to investigate the characteristics of bleeding peptic ulcer in Japan, including the role of H. pylori infection and NSAIDs use. Patients and Methods: This study was prospectively intended for patients who have a bleeding peptic ulcer at emergent endoscopy in our...

  • Triple therapy wipes out H. pylori, regardless of previous Rx choice.  // Modern Medicine;Mar95, Vol. 63 Issue 3, p55 

    Presents an abstract of the article `Triple Therapy Eradicated H. Pylori Equally in Patients Pre-treated With Omeprazole or Ranitidine: A 12-month Follow-up,' by A. Archimandritis, V. Balastos, et al dated January 1995.

  • Ulcer-causing bacterium now detectable by breath test.  // Medical Update;Nov96, Vol. 20 Issue 5, p1 

    Reports that the United States Food & Drug Administration (FDA) has approved the first antibiotic treatment for peptic ulcers. Combining of omeprazole and clarithromycin; Eradication of the Helicobacter pylori infection.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics