TITLE

Action potentials of HL-1 cells recorded with silicon nanowire transistors

AUTHOR(S)
Eschermann, Jan Felix; Stockmann, Regina; Hueske, Martin; Xuan Thang Vu; Ingebrandt, Sven; Offenhäusser, Andreas
PUB. DATE
August 2009
SOURCE
Applied Physics Letters;8/24/2009, Vol. 95 Issue 8, p083703
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Silicon nanowire (NW) transistors were fabricated in a top-down process. These devices were used to record the extracellular potential of the spontaneous activity of cardiac muscle HL-1 cells. Their signals were measured by direct dc sampling of the drain current. An improved signal-to-noise ratio compared to planar field-effect devices was observed. Furthermore the signal shape was evaluated and could be associated to different membrane currents. With these experiments, a qualitative description of the properties of the cell-NW contact was obtained and the suitability of these sensors for electrophysiological measurements in vitro was demonstrated.
ACCESSION #
43944839

 

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