Direct ovarian effects and safety aspects of GnRH agonists and antagonists

Tarlatzis, B. C.; Kolibianakis, E. M.
November 2002
Reproductive BioMedicine Online (Reproductive Healthcare Limited;Nov2002 Supplement 1, Vol. 5 Issue S1, p8
Academic Journal
The wide application of gonadotrophin-releasing hormone (GnRH) analogues in assisted reproduction has raised concerns about their potential extra-pituitary actions. Although data from animal studies support the presence of ovarian GnRH receptors and of direct ovarian effects of GnRH analogues, this has not been unequivocally demonstrated in humans. Available evidence suggests, however, the existence of GnRH receptors in human granulosaluteal cells, while the majority of the studies performed showed that progesterone is inhibited by GnRH agonists in vitro. On the other hand, no difference seems to exist between agonists and antagonists in terms of granulosa-luteal cell steroidogenesis under basal conditions. So far, no studies have suggested an adverse effect of GnRH analogues on the developing human follicle. Moreover, the physiological significance of a direct in-vitro ovarian effect of GnRH analogues remains to be established.


Related Articles

  • The role of GnRH antagonists in assisted reproduction. Barri, Pedro N.; Martinez, Francisca; Coroleu, Buenaventura; Tur, Rosa // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Nov2002 Supplement 1, Vol. 5 Issue S1, p14 

    The different schemes of application of gonadotrophin-releasing hormone (GnRH) antagonists in ovarian stimulation protocols for assisted reproduction are reviewed. Starting from the initial schemes of single and/or multiple doses, the efficacy of GnRH antagonists in 'soft' protocols of ovarian...

  • ART, clinical: GnRH agonist/antagonist.  // Human Reproduction;Jul2007 Supplement 1, Vol. 22, pi120 

    The article presents abstracts on the use of gonadotropin-releasing hormone (GnRH) agonists and antagonists in assisted reproductive technology (ART), including the administration of gonadoliberine analogues (GnRH-a) to patients with Hodgkin lymphoma (HL) during chemotherapy and prevention of...

  • The luteal phase after ovarian stimulation. Kolibianakis, Efstratios M.; Devroey, Paul // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Nov2002 Supplement 1, Vol. 5 Issue S1, p26 

    Evaluation of the luteal phase after ovarian stimulation presents several difficulties. Until today, it has not been proved that in cycles stimulated with clomiphene citrate/human menopausal gonadotrophins, luteal supplementation with progesterone significantly increases implantation rate. On...

  • Comparison of GnRH agonists and antagonists in the outcome of IVF/ICSI in women with polycystic ovary syndrome. Zeinalzadeh, M.; Norani, N.; Esmaeilzadeh, S.; Yousefniapasha, Y.; Firoozpour, M.; Khafri, S. // Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p58 

    Introduction: To compare the outcome of using gonadotropin-releasing hormone (GnRH) antagonists versus agonists in women with polycystic ovary syndrome (PCOS) who underwent controlled ovarian hyper stimulation (COH) for assisted reproductive techniques (ART). Materials and Methods: A total of...

  • Comparison of GnRH antagonist versus GnRH agonist on ART outcomes in patients with poor ovarian response. Zeinalzadeh, M.; Yousefniapasha, Y.; Jorsaray, G.; Firoozpour, M. // Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p58 

    Introduction: Studies revealed that 9-24% of women who underwent ovarian stimulation induced by gonadotropins for infertility treatment represented weak ovulatory responses. The aim of the study was to compare IVF outcomes in poor-responder patients undergoing GnRH agonist protocol versus...

  • GnRH-antagonist is Useful as an Alternative to GnRH Agonist.  // Fertility Weekly;1/25/2010, p9 

    The article reports on the study conducted by Razieh Dehghani Firouzabadi and colleagues to examine the effectiveness of gonadotropin-releasing hormone (GnRH) antagonist protocol versus GnRH agonist long protocol in the first cycle of assisted reproductive technique (ART) among women in Iran....

  • Gonadotropin-Releasing Hormone (GnRH) - Antagonist Versus GnRH-Agonist in Ovarian Stimulation of Poor Responders Undergoing IVF. fasouliotis, Sozos J.; Laufer, Neri; Sabbagh-Ehrlich, Shelley; Lewin, Aby; Hurwitz, Arye; Simon, Alex // Journal of Assisted Reproduction & Genetics;Nov2003, Vol. 20 Issue 11, p455 

    Purpose: The objective of this study was to compare the efficacy of GnRH-antagonists to GnRH-agonists in ovarian stimulation of poor responders undergoing IVF. Methods: Retrospective analysis of our data revealed that 56 patients underwent treatment with a GnRH-agonist according to the flare-up...

  • Ovarian stimulation in women with high and low body mass index: GnRH agonist versus GnRH antagonist. Kumbak, Banu; Akbas, Hande; Sahin, Levent; Karlikaya, Guvenc; Karagozoglu, Hale; Kahraman, Semra // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Mar2010, Vol. 20 Issue 3, p314 

    This study evaluated women with a high body mass index (BMI) (>40 kg/m²) and low BMI (<18 kg/m²) undergoing assisted reproduction treatment and determined whether the type of gonadotrophin-releasing hormone (GnRH) analogue used has an impact on cycle parameters and outcome. The study...

  • GnRH Antagonist Produces Similar Results as GnRH-Agonist.  // Fertility Weekly;12/6/2010, p8 

    The article presents a study which aims to determine the effectiveness of luteinizing hormone releasing hormone (GnRH) antagonist and luteinizing hormone releasing hormone (GnRH) agonist protocol in polycystic ovary syndrome (PCOS) patients pretreated with oral contraceptive pill (OCP)....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics