Oseltamivir-Resistant Novel Influenza A (H1N1) Virus Infection in Two Immunosuppressed Patients -- Seattle, Washington, 2009

Englund, J.; Zerr, D.; Heath, J.; Pergam, S.; Kuypers, J.; Yager, J.; Boeckh, M.; Mattson, D.; Whittington, N.; Whimbey, E.; Duchin, J.; Uyeki, T.; Deyde, V.; Okomo-Adhiambo, M.; Sheu, T.; Trujillo, A.; Klimov, A.; Gubareva, L.; Kay, M.
August 2009
MMWR: Morbidity & Mortality Weekly Report;8/21/2009, Vol. 58 Issue 32, p893
The article reports on resistance to oseltamivir, an antiviral medication, in two immunosuppressed patients with novel influenza A (H1N1) in Seattle, Washington. For both patients, the virus was initially susceptible to oseltamivir but resistance to the drug was later detected. Summaries of the case histories and investigations into the causes of viral mutation are presented. The importance of antiviral drug resistance monitoring and implications for infection control are also discussed.


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