Effect of simvastatin on plasma interleukin-6 in patients with unstable angina

Hai-Zhou Ren; Long-Le Ma; Le-Xin Wang
August 2009
Clinical & Investigative Medicine;Aug2009, Vol. 32 Issue 4, pE280
Academic Journal
Purpose: The primary aim of the study was to investigate the effect of sinvastatin on plasma interleukin-6 (IL-6) in patients with unstable angina pectoris (UAP). Methods: Eighty-six patients with UAP were randomized into simvastatin (40 mg/d for 4 weeks) and the placebo group. Plasma IL-6 was measured by ELISA. Results: There was a reduction in the plasma total cholesterol and LDL in the simvastatin group (P<0.01). The simvastatin group also had better angina control than the placebo group (post-treatment angina score, 0.72±0.59 vs 1.07±0.76, P<0.05). Following treatment, the average left ventricular ejection fraction in the simvastatin group was higher than in the placebo group (0.54±0.06 vs 0.51±0.05, P<0.05), whereas the plasma BNP levels were lower (16.8±6.6 vs 26.4±1.4, P<0.01). Before treatment, there was no difference in the plasma levels of IL-6 between the simvastatin and the placebo groups (P>0.05). Following treatment, the IL-6 levels in the simvastatin group were lower than in the placebo group (0.7±0.4 vs 1.2±0.4 pg/ml, P<0.05). Conclusions: Short-term treatment with simvastatin reduces plasma IL-6. The anti-inflammatory effect of simvastatin may contribute to its beneficial effects on the ventricular function and angina control.


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