Phylogenetic and Case-Control Study on Hepatitis E Virus Infection in Germany

Wichmann, Ole; Schimanski, Sven; Koch, Judith; Kohler, Martin; Rothe, Camilla; Plentz, Annelie; Jilg, Wolfgang; Stark, Klaus
December 2008
Journal of Infectious Diseases;12/15/2008, Vol. 198 Issue 12, p1732
Academic Journal
Background. Hepatitis E is a classic water-borne disease in developing countries. In Germany, hepatitis E virus (HEV) infections are notifiable. The number of non-travel-associated infections has increased in recent years, but the route of transmission in most is unknown. Our objective was to determine risk factors for autochthonous HEV infections in Germany. Methods. Cases of HEV met clinical definitions and were confirmed by laboratory analysis (defined as detection of HEV by polymerase chain reaction [PCR] or immunoglobulin M by serologic testing). PCR products from blood or stool samples were genotyped for phylogenetic analysis. A case-control study included case subjects with autochthonous HEV infection and matched control subjects who were randomly recruited from a population-based telephone list. Results. From May 2006 through August 2007, 76 of 96 persons for whom HEV infection had been reported to the routine surveillance system were interviewed. Sixty-six persons had disease that fulfilled the inclusion criteria: 45 (68%) had autochthonous infection, and 21 (32%) had travel-associated disease. Genotypes 3 or 4 were present in 15 of 15 persons with autochthonous infection, and genotype 1 was present in 8 of 9 persons with travel-associated infection. In conditional logistic regression involving 45 case subjects and 135 control subjects, consumption of offal (41% vs. 19%; odds ratio [OR], 2.7; 95% confidence interval [CI], 1.2- 6.2) and wild-boar meat (20% vs. 7%; OR, 4.3; 95% CI, 1.2-15.9) were independently associated with autochthonous HEV infection. Conclusion. Hepatitis E is endemic in Germany and likely exists as a food-borne zoonosis. Implicated meat products should be investigated to provide recommendations for preventive measures.


Related Articles

  • Impact of the Novel Hepatotropic Viruslike Agent NV-F during Chronic Hepatitis C Virus Infection. Chau-Ting Yeh; Chao-Wei Hsu; Ming-Ling Chang; Mei-Ling Tsao // Journal of Infectious Diseases;12/15/2008, Vol. 198 Issue 12, p1742 

    NV-F is a novel hepatotropic viruslike agent. To investigate the impact of the NV-F agent during chronic hepatitis C virus (HCV) infection, 101 consecutive patients with chronic HCV infection were evaluated. NV-F DNA in serum samples and NV-F antigen expression in liver tissues were assessed....

  • Hepatitis E virus genotype 3f sequences from pigs in Thailand, 2011-2012. Keawcharoen, Juthatip; Thongmee, Thanunrat; Panyathong, Raphee; Joiphaeng, Pichai; Tuanthap, Supansa; Oraveerakul, Kanisak; Theamboonlers, Apiradee; Poovorawan, Yong // Virus Genes;Apr2013, Vol. 46 Issue 2, p369 

    Phylogenetic analysis of partial ORF1 and ORF2 genes of Hepatitis E virus (HEV) strains from pigs in Thailand during 2011-2012 was performed. The result indicated that the current Thai strains belonged to the genotype 3 subgroup 3f, which were similar to the previous HEVs circulating in humans...

  • Does Hepatitis E Viral Load and Genotypes Influence the Final Outcome of Acute Liver Failure During Pregnancy? Kar, Premashis; Jilani, Nishat; Husain, Syed A.; Pasha, Sayed Tazeen; Anand, Ranjana; Rai, Arvind; Das, Bhudev C. // American Journal of Gastroenterology;Oct2008, Vol. 103 Issue 10, p2495 

    BACKGROUND: Hepatitis E is a major health problem in developing countries including India. The incidence and mortality rate in pregnant women with fulminant hepatic failure (FHF) due to hepatitis E virus (HEV) has been reported to be significantly higher, specifically in Asian women. Pregnancy...

  • Molecular characterisation of human hepatitis E virus from Italy: comparative analysis of five reverse transcription-PCR assays. Rosa, Giuseppina La; Fratini, Marta; Muscillo, Michele; Iaconelli, Marcello; Taffon, Stefania; Equestre, Michele; Chionne, Paola; Madonna, Elisabetta; Pisani, Giulio; Bruni, Roberto; Ciccaglione, Anna Rita // Virology Journal;2014, Vol. 11 Issue 1, p1 

    Background Hepatitis E (HEV) is an important public-health concern as a major cause of enterically transmitted hepatitis worldwide. In industrialised countries it is considered rare, and largely confined to travellers returning from endemic areas. However, autochthonous (locally acquired) HEV...

  • hepatitis, viral. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p376 

    An encyclopedia entry for "viral hepatitis" is presented. It refers to a type of hepatitis caused by the hepatitis E virus transmitted in contaminated food or drink. It is similar to hepatitis A.

  • Hepatitis B in Moroccan health care workers. K. Djeriri; H. Laurichesse; J. L. Merle; R. Charof; A. Abouyoub; L. Fontana; N. Benchemsi; E. Elharti; R. El Aouad; A. Chamoux; J. Beytout // Occupational Medicine;Sep2008, Vol. 58 Issue 6, p419 

    Aim To evaluate knowledge and perception of hepatitis B, including prevention, among Moroccan health care workers (HCWs) and to estimate seroprevalence of hepatitis B and vaccine coverage (VC). Methods Four hundred and twenty HCWs were randomly selected and stratified by site: 120 in Rabat, 140...

  • Hepatitis B viral factors and clinical outcomes of chronic hepatitis B. Chih-Lin Lin; Jia-Horng Kao // Journal of Biomedical Science;Mar2008, Vol. 15 Issue 2, p137 

    Hepatitis B virus (HBV) infection is an important health problem and the major cause of chronic hepatitis, cirrhosis as well as hepatocellular carcinoma (HCC) worldwide. The natural history of chronic HBV infection can be divided into 4 dynamic phases in HBV carriers who acquire the virus early...

  • Maternal and Fetal Outcomes in Pregnant Women with Acute Hepatitis E Virus Infection. Patra, Sharda; Kumar, Ashish; Trivedi, Shubha Sagar; Puri, Manju; Sarin, Shiv Kumar // Annals of Internal Medicine;7/3/2007, Vol. 147 Issue 1, p28 

    Background: Hepatitis E virus (HEV) infection is known to cause severe liver disease in pregnant women. It is unclear whether obstetric and fetal outcomes are worse in pregnant women with HEV infection than in women with other forms of viral hepatitis. Objective: To compare maternal, obstetric,...

  • Acute viral hepatitis morbidity and mortality associated with hepatitis E virus infection: Uzbekistan surveillance data. Sharapov, Makhmudkhan B.; Favorov, Michael O.; Yashina, Tatiana L.; Brown, Matthew S.; Onischenko, Gennady G.; Margolis, Harold S.; Chorba, Terence L. // BMC Infectious Diseases;2009, Vol. 9 Issue 1, Special section p1 

    Background: In Uzbekistan, routine serologic testing has not been available to differentiate etiologies of acute viral hepatitis (AVH). To determine the age groups most affected by hepatitis E virus (HEV) during documented AVH epidemics, trends in AVH-associated mortality rate (MR) per 100,000...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics