2009 - Oral anticoagulant therapy safely prevented stroke in older patients with atrial fibrillation

Dunn, Andrew
July 2009
ACP Journal Club;7/21/2009, Vol. 151 Issue 1, p2
Academic Journal
The article focuses on a clinical study to analyze the effectiveness and safety of oral anticoagulant (OAC) and antiplatelet (AP) therapies for stroke prevention change with age, in patients with atrial fibrillation. For this study individual patient data meta-analysis of 12 randomized controlled trials (RCTs) were conducted, out of which 6 were placebo-controlled. The trial found that older age was associated with increased risk for all outcomes.


Related Articles

  • Apixaban better than warfarin in AF.  // Pulse;9/7/2011, Vol. 71 Issue 28, p15 

    The article reports on the result of a randomised clinical trial which shows that apixaban, a new anticoagulant, is better than warfarin for preventing systemic embolism and stroke in patients with atrial fibrillation.

  • Periprocedural dabigatran anticoagulation for atrial fibrillation ablation: do we have enough information to make a rational decision. Noheria, Amit; Asirvatham, Samuel // Journal of Interventional Cardiac Electrophysiology;Sep2013, Vol. 37 Issue 3, p209 

    The authors discuss the study by Steinberg and colleagues which aims to examine the efficacy of periprocedural anticoagulation with dabigatran against warfarin for atrial fibrillation (AF). They mention that the authors of the study must be praised for their meta-analysis, which they considered...

  • Atrial fibrillation treatment focus shifts from rhythm to rate control. Glatter, Kathryn; Herweg, Bengt; Jaffe, Charles // Patient Care;Jan2006, Vol. 40 Issue 1, p58 

    The article presents a meta-analysis of randomized clinical trials of initial therapy for atrial fibrillation (AF) comparing rhythm and rate control. It lists the reason against the use of rhythm control as first-line strategy in patients with persistent AF. It details clinical considerations...

  • Perioperative Bridging Anticoagulation Unhelpful for Invasive Procedures. EBELL, MARK H. // American Family Physician;1/15/2016, Vol. 93 Issue 2, p130 

    The article examines whether bridging anticoagulation during invasive procedures improve outcomes in patients with atrial fibrillation who take warfarin, or Coumadin. Topics discussed include warfarin obtained by participants for three months, absence of anticoagulation in the placebo group for...

  • Anticoagulation: Is lower necessarily better? Pinkowish, Mary Desmond // Patient Care;9/30/1996, Vol. 30 Issue 15, p11 

    Examines the use of anticoagulants to patients with nonrheumatic atrial fibrillation. Possibility of a significant hemorrhage; Intensity of anticoagulation regimen to reduce the risk of schemic stroke; Increase of stroke risk at international normalized ratio values above 4.0.

  • Atrial fibrillation: Reducing stroke risk with low-dose anticoagulation. Dalen, James E. // Geriatrics;May94, Vol. 49 Issue 5, p24 

    Discusses the use of low-dose anticoagulants in reducing stroke risk in patients with atrial fibrillation (AF). AF and systemic embolism; Clinical considerations; Diagnosis; Causes of AF; Clinical studies on the use of low-dose anticoagulants in AF; Key findings; Potential complications of...

  • Antithrombotic therapy for atrial fibrillation. Lip, Gregory Y H; Hart, Robert G; Conway, Dwayne S G // BMJ: British Medical Journal (International Edition);11/2/2002, Vol. 325 Issue 7371, p1022 

    Discusses the use of antithrombotic therapy for atrial fibrillation. Definition of atrial fibrillation as the most common sustained disorder of cardiac rhythm; Risks associated with atrial fibrillation such as ischaemic stroke; Evidence from clinical trials; Discussion about who to treat;...

  • Guidelines on anticoagulant treatment in atrial... Thomson, Richard; McElroy, Helen; Sudlow, Mark // BMJ: British Medical Journal (International Edition);02/14/98, Vol. 316 Issue 7130, p509 

    Describes the content of guidelines on the use of anticoagulant treatment in patients with atrial fibrillation. Methodology of the study; Impact of variations in guidelines on treatment; Reason for the variations; Recommendations of the researchers. INSET: Comments from interviews with...

  • Novel Oral Anticoagulants in Cardiovascular Disease. Gallego, Pilar; Roldán, Vanessa; Lip, Gregory Y. H. // Journal of Cardiovascular Pharmacology & Therapeutics;Jan2014, Vol. 19 Issue 1, p34 

    Nonvalvular atrial fibrillation (AF) confers an increased risk of thromboembolism, with a 5-fold higher risk of ischemic stroke. Oral anticoagulation (OAC) has shown to be highly effective in preventing stroke and mortality compared to placebo and is also used in patients without AF for both...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics