A new stilbene glycoside from the n-butanol fraction of Veratrum dahuricum

Li-Min Dai; Jian Tang; Hui-Liang Li; Yun-Heng Shen; Cai-Yun Peng; Wei-Dong Zhang
May 2009
Chemistry of Natural Compounds;May2009, Vol. 45 Issue 3, p325
Academic Journal
A new stilbene glycoside, 5-methylresveratrol-3,4′- O- β-D-diglucopyranoside ( 1), was isolated from the n-butanol fraction of the rhizomes of Veratrum dahuricum, together with five known stilbenoids: resveratrol-3- O- β-D-glycoside ( 2), 4′-methylresveratrol-3- O- β-D-glycoside ( 3), oxyresveratrol-4′- O- β-D-glycoside ( 4), oxyresveratrol-3- O- β-D-glycoside ( 5), and oxyresveratrol-3,4′- O- β-D-diglycoside ( 6), and found for the first time in the investigated plant. The structures of six isolates were identified on the basis of 1D and 2D NMR data. Compounds 1–6 showed platelet aggregation inhibition, and compound 1 had an IC50 value of 383.6 μM against platelet aggregation induced by AA.


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