TITLE

Synthesis and antimycobacterial activity of some steroidal derivatives of tigogenin

AUTHOR(S)
Merlani, M.; Amiranashvili, L.; Kemertelidze, E.; Mulkidzhanyan, K.
PUB. DATE
May 2009
SOURCE
Chemistry of Natural Compounds;May2009, Vol. 45 Issue 3, p389
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Some 5α-type steroidal derivatives of the steroidal sapogenin tigogenin were synthesized. The structures of the synthesized derivatives were characterized by spectral methods and elemental analysis. The antituberculosis activity of the compounds toward Mycobacterium tuberculosis strain H37Rv was studied in vitro (Microplate Alamar Blue Assay) in BACTEC 12B medium and was compared with that of isoniazide. Some of the synthesized compounds exhibited high (92-98%) antimycobacterial activity.
ACCESSION #
43781491

 

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