Exonization of the LTR transposable elements in human genome

January 2007
BMC Genomics;2007, Vol. 8, p291
Academic Journal
No abstract available.


Related Articles

  • Mammals' Genomes Getting Smaller.  // USA Today Magazine;Jun2010, Vol. 138 Issue 2781, p9 

    The article reveals chromosomal evidence found by scientists from Indiana University, Bloomington, Indiana which showed that genomes of mammals have continued to shrink since the extinction of the dinosaurs and continue to shrink as a result of natural selection and the occurrence of long...

  • SERpredict: Detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements. Mersch, Britta; Sela, Noa; Ast, Gil; Suhai, Sándor; Hotz-Wagenblatt, Agnes // BMC Genetics;2007, Vol. 8, p78 

    Background: Transposed elements (TEs) are known to affect transcriptomes, because either new exons are generated from intronic transposed elements (this is called exonization), or the element inserts into the exon, leading to a new transcript. Several examples in the literature show that...

  • LTR retrotransposons as source of promoters in the drosophila genome. Makunin, I. V.; Yurlova, A. A. // Russian Journal of Genetics;Sep2010, Vol. 46 Issue 9, p1067 

    Mobile genetic elements affect genome structure and function in various ways. Significant number of genes in human and mouse are transcribed from alternative promoters located in LTR retrotransposons. As a rule, these retrotransposons are located upstream of annotated genes, and their promoters...

  • The impact of retrotransposons on human genome evolution. Cordaux, Richard; Batzer, Mark A. // Nature Reviews Genetics;Oct2009, Vol. 10 Issue 10, p691 

    Their ability to move within genomes gives transposable elements an intrinsic propensity to affect genome evolution. Non-long terminal repeat (LTR) retrotransposons--including LINE-1, Alu and SVA elements--have proliferated over the past 80 million years of primate evolution and now account for...

  • Distributions of Transposable Elements Reveal Hazardous Zones in Mammalian Introns. Ying Zhang; Romanish, Mark T.; Mager, Dixie L. // PLoS Computational Biology;May2011, Vol. 7 Issue 5, p1 

    Comprising nearly half of the human and mouse genomes, transposable elements (TEs) are found within most genes. Although the vast majority of TEs in introns are fixed in the species and presumably exert no significant effects on the enclosing gene, some markedly perturb transcription and result...

  • Control of mammalian retrotransposons by cellular RNA processing activities. Heras, Sara R.; Macias, Sara; Cáceres, Javier F.; Garcia-Perez, Jose L. // Mobile Genetic Elements (2159-2543);Mar2014, Vol. 4, p1 

    The article offers an overview of study results showing the control of ribonucleic acid (RNA) processing events over the activity of mammalian retrotransposons. Findings discussed include the role of transposable elements (TEs) in shaping eukaryotic genomes, the activity of the non-long terminal...

  • Alternative splicing: Regulating Alu element 'exonization'. Stower, Hannah // Nature Reviews Genetics;Mar2013, Vol. 14 Issue 3, p152 

    The article discusses the Alu elements as the most abundant transposable elements in the human genome which contain characteristic cryptic splice sites.

  • LTRharvest, an efficient and flexible software for de novo detection of LTR retrotransposons. Ellinghaus, David; Kurtz, Stefan; Willhoeft, Ute // BMC Bioinformatics;2008, Vol. 9, Special section p1 

    Background: Transposable elements are abundant in eukaryotic genomes and it is believed that they have a significant impact on the evolution of gene and chromosome structure. While there are several completed eukaryotic genome projects, there are only few high quality genome wide annotations of...

  • LTR_FINDER: an efficient tool for the prediction of full-length LTR retrotransposons. Xu, Zhao; Wang, Hao // Nucleic Acids Research;2007, Vol. 35 Issue suppl_2, pW265 

    Long terminal repeat retrotransposons (LTR elements) are ubiquitous eukaryotic transposable elements. They play important roles in the evolution of genes and genomes. Ever-growing amount of genomic sequences of many organisms present a great challenge to fast identifying them. That is the first...

  • Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene. Amit, Maayan; Sela, Noa; Keren, Hadas; Melamed, Ze'ev; Muler, Inna; Shomron, Noam; Izraeli, Shai; Ast, Gil // BMC Molecular Biology;2007, Vol. 8, p109 

    Background: Gene duplication and exonization of intronic transposed elements are two mechanisms that enhance genomic diversity. We examined whether there is less selection against exonization of transposed elements in duplicated genes than in single-copy genes. Results: Genome-wide analysis of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics