Gene expression variation between distinct areas of breast cancer measured from paraffin-embedded tissue cores

January 2008
BMC Genetics;2008, Vol. 9, p343
Academic Journal
No abstract available.


Related Articles

  • Differential expression of breast cancer-associated genes between stage- and age-matched tumor specimens from African- and Caucasian-American Women diagnosed with breast cancer. Grunda, Jessica M; Steg, Adam D; Qinghua He; Steciuk, Mark R; Bryan-Parker, Susanne; Johnson, Martin R; Grizzle, William E // BMC Research Notes;2012, Vol. 5 Issue 1, p248 

    Background: Recent studies suggest that the poorer breast cancer outcome observed in African-American women (AAW) may, in part, result from underlying molecular factors. The purpose of this study was to investigate gene expression differences between Caucasian-American women (CAW) and AAW that...

  • Determination of the methylation status of MGMT in different regions within glioblastoma multiforme. Hamilton, Mark; Roldán, Gloria; Magliocco, Anthony; McIntyre, John; Parney, Ian; Easaw, Jacob // Journal of Neuro-Oncology;Apr2011, Vol. 102 Issue 2, p255 

    Epigenetic silencing of the MGMT gene through promoter methylation correlates with improved survival in Glioblastoma Multiforme (GBM) patients receiving concurrent chemoradiotherapy. Although the clinical benefit is primarily seen in patients with methylated MGMT promoter, some unmethylated...

  • Application of RT-PCR in formalin-fixed and paraffin-embedded lung cancer tissues. Fan ZHANG; Zhuo-min WANG; Hong-yu LIU; Yun BAI; Sen WEI; Ying LI; Min WANG; Jun CHEN; Qing-hua ZHOU // Acta Pharmacologica Sinica;Jan2010, Vol. 31 Issue 1, p111 

    AbstractAim:To analyze gene expression in formalin-fixed, paraffin-embedded lung cancer tissues using modified method.Methods:Total RNA from frozen tissues was extracted using TRIZOL reagent. RNA was extracted from formalin-fixed, paraffin-embedded tissues by digestion with proteinase K before...

  • The fibromatosis signature defines a robust stromal response in breast carcinoma. Beck, Andrew H.; Espinosa, Inigo; Gilks, C. Blake; Van De Rijn, Matt; West, Robert B. // Laboratory Investigation (00236837);Jun2008, Vol. 88 Issue 6, p591 

    Breast cancer is a heterogeneous disease, and the influence of stromal gene and protein expression patterns on the biological and clinical heterogeneity of the disease is poorly understood. We previously demonstrated that evaluation of the gene expression patterns of two soft-tissue tumors...

  • DNA-PK, the DNA-activated protein kinase, is differentially expressed in normal and malignant human tissues. Moll, Ute; Lau, Raymond; Sypes, Michael A; Gupta, Malini M; Anderson, Carl W // Oncogene;5/20/99, Vol. 18 Issue 20, p3114 

    DNA-PK is a nuclear, serine/threonine protein kinase required for repairing DNA double-strand breaks and for V(D)J recombination. To determine the distribution of DNA-PK in human tissues, we assayed paraffin-embedded sections of normal and cancerous tissues for DNA-PKcs and Ku80 by...

  • Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients.  // Breast Cancer Research;2012, Vol. 14 Issue 1, pR51 

    The article focuses on a study which aims at defining the gene expression subtypes of breast cancer microenvironment. It states that gene expression indicates an activated wound response which is common in non-neoplastic tissues that are adjacent to breast cancer. It mentions that in the study,...

  • Abstracts From the College of American Pathologists 2004 Annual Meeting (CAP '04).  // Archives of Pathology & Laboratory Medicine;Apr2005, Vol. 129 Issue 4, p547 

    The article presents abstracts of medical research. They include "Application of Gene Expression Profiling From Formalin-Fixed Paraffin-Embedded Tissues," "Discovery of New Gene Expression Predictors for Adjuvant Tamoxifen Outcome for Breast Cancer Patients." and "Highest Gleason Grade of...

  • Phosphorylation of p90RSK is associated with increased response to neoadjuvant chemotherapy in ER-positive breast cancer. Moon, Hyeong-Gon; Yi, Jae Kyo; Kim, Hee Sung; Lee, Hea Young; Lee, Kyung-Min; Yi, Minju; Ahn, Sookyung; Shin, Hee-Chul; Ju, Ji-hyun; Shin, Incheol; Han, Wonshik; Noh, Dong-Young // BMC Cancer;2012, Vol. 12 Issue 1, p585 

    Background: The clinical implication of Ras/Raf/ERK pathway activity in breast cancer tissue and its association with response to chemotherapy is controversial. We aimed to explore the value of p90RSK phosphorylation, a downstram molecule of the pathway, in predicting chemotherapy response in...

  • Meme Kanserlerinde HtrA2 Gen Ä°fadesinin Analizi. Akkafa, Feridun; Arslan, Ahmet; Öztuzcu, Serdar; Özardalı, H. İlyas; Gökalp, Avni; Özkara, Esma; Bozdağ, Zehra; Camcı, Celalettin; Aytekin, Alper // Journal of Harran University Medical Faculty;2014, Vol. 11 Issue 2, p111 

    Background: The purposes of this study were to measure both the protein and mRNA expression levels of HtrA2 gene in human with breast cancer tissues and their adjacent normal breast tissues. Methods: mRNA expression levels in tissues taken surgically from 53 patients detection of fresh tissues...

  • Prospective dual role of mesenchymal stem cells in breast tumor microenvironment. Senst, Christiane; Nazari-Shafti, Timo; Kruger, Stefan; Bentrup, Kirstin; Dupin, Charles; Chaffin, Abigail; Srivastav, Sudesh; Wörner, Philipp; Abdel-Mageed, Asim; Alt, Eckhard; Izadpanah, Reza // Breast Cancer Research & Treatment;Jan2013, Vol. 137 Issue 1, p69 

    Breast cancer tissue is a heterogeneous cellular milieu comprising cancer and host cells. The interaction between breast malignant and non-malignant cells takes place in breast tumor microenvironment (TM), and has a crucial role in breast cancer progression. In addition to cellular component of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics