TITLE

STAT3 can be activated through paracrine signaling in breast epithelial cells

PUB. DATE
January 2008
SOURCE
BMC Genetics;2008, Vol. 9, p302
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
43749576

 

Related Articles

  • IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR. Rojas, A; Liu, G; Coleman, I; Nelson, P S; Zhang, M; Dash, R; Fisher, P B; Plymate, S R; Wu, J D // Oncogene;5/19/2011, Vol. 30 Issue 20, p2345 

    As an established mediator of inflammation, interleukin-6 (IL-6) is implicated to facilitate prostate cancer progression to androgen independence through transactivation of the androgen receptor. However, whether IL-6 has a causative role in de novo prostate tumorigenesis was never investigated....

  • Resistance of Cancer Cells to Targeted Therapies Through the Activation of Compensating Signaling Loops. von Manstein, Viktoria; Chul Min Yang; Richter, Diane; Delis, Natalia; Vafaizadeh, Vida; Groner, Bernd // Current Signal Transduction Therapy;Dec2013, Vol. 8 Issue 3, p193 

    The emergence of low molecular weight kinase inhibitors as "targeted" drugs has led to remarkable advances in the treatment of cancer patients. The clinical benefits of these tumor therapies, however, vary widely in patient populations and with duration of treatment. Intrinsic and acquired...

  • The Role of STATs in Apoptosis. Battle, T.E.; Frank, D.A. // Current Molecular Medicine;Jun2002, Vol. 2 Issue 4, p381 

    Signal transducers and activators of transcription (STATs) are transcription factors that mediate cytokine and growth factor induced signals that culminate in various biological responses, including proliferation and differentiation. Recent studies indicate a role for STATs in apoptosis as well....

  • Protective Function of STAT3 in CVB3-Induced Myocarditis. Lindner, Diana; Hilbrandt, Moritz; Marggraf, Katharina; Becher, P. Moritz; Hilfiker-Kleiner, Denise; Klingel, Karin; Pauschinger, Matthias; Schultheiss, Heinz-Peter; Tschöpe, Carsten; Westermann, Dirk // Cardiology Research & Practice;2012, p1 

    The transcription factor signal transducer and activator of transcription 3 (STAT3) is an important mediator of the inflammatory process. We investigated the role of STAT3 in viral myocarditis and its possible role in the development to dilated cardiomyopathy. We used STAT3-deficent mice with a...

  • JAK2-STAT5B pathway and osteoblast differentiation. Pramod Darvin; Youn Hee Joung; Young Mok Yang // JAK-STAT;Oct2013, Vol. 2 Issue 4, pe24931-1 

    Osteoblast differentiation is a critical step in the maintenance of bone homeostasis. Osteoblast differentiation is generally maintained by growth hormone (GH) and various other endocrine and autocrine/paracrine factors. JAK2-STAT5B pathway is a central axis in the mechanism of GH signaling....

  • JAK2-STAT5B pathwayand osteoblast differentiation. Darvin, Pramod; Youn Hee Joung; Young Mok Yang // JAK-STAT;Oct-Dec2013, Vol. 2 Issue 4, pe24931-1 

    Osteoblast differentiation is a critical step in the maintenance of bone homeostasis. Osteoblast differentiation is generally maintained by growth hormone (GH) and various other endocrine and autocrine/paracrine factors. JAK2-STAT5B pathway is a central axis in the mechanism of GH signaling....

  • The JAK-STAT pathway in hypertrophic stress signaling and genomic stress response. Wagner, Michael A.; Siddiqui, M. A. Q. // JAK-STAT;Apr-Jun2012, Vol. 1 Issue 2, p1 

    The JAK-STAT signaling pathway plays a central role in transducing stress and growth signals in the hypertrophic heart. Unlike most signal transducers, JAKs and STATs signal in a number of different ways, both within the JAK-STAT pathway and in collaboration with other signaling pathways. In...

  • STAT3 inhibitors for cancer therapy. Fagard, Remi; Metelev, Valeri; Souissi, Inès; Baran-Marszak, Fanny // JAK-STAT;Jan-Mar2013, Vol. 2 Issue 1, p1 

    The signal transducer and activator of transcription STAT3 is a transcription factor which plays a key role in normal cell growth and is constitutively activated in about 70% of solid and hematological cancers. Activated STAT3 is phosphorylated on tyrosine and forms a dimer through...

  • Mechanisms of EGF Regulation of COX-2 Through the STAT5 Signaling Pathway in Human Lung Adenocarcinoma A549 Cells. Shouqiang CAO; Guibin ZHAO; Qing DONG; Jingquan HAN; Yanzhong XIN; Yubo YAN; Jiyao LI; Jian CUI // Chinese Journal of Lung Cancer;Apr2013, Vol. 16 Issue 4, p169 

    Background and objective It has been proved that cyclooxygenase-2 (COX-2) is a key factor in lung cancer oncogenesis. COX-2 can be induced by a number of cytokines and growth factors and can be regulated by the JAK/ STAT signaling pathway. Inhibiting the expression of COX-2 can prevent the...

  • The Role of STAT3 Signaling in Mediating Tumor Resistance to Cancer Therapy. Tan, Fiona H.; Putoczki, Tracy L.; Stylli, Stanley S.; Luwor, Rodney B. // Current Drug Targets;Dec2014, Vol. 15 Issue 14, p1341 

    Signal transducer and activator of transcription 3 (STAT3) is activated in many cancer types and can regulate pathways involving tumorigenesis, cell proliferation, cell survival and angiogenesis. Upstream cytokine signaling through multiple trans-membrane receptors can enhance the activation of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics