Characterization of cells recovered from the xenotransplanted NG97 human-derived glioma cell line subcultured in a long-term in vitro

January 2008
BMC Genetics;2008, Vol. 9, p291
Academic Journal
No abstract available.


Related Articles

  • Tumor-Specific Chromosome Mis-Segregation Controls Cancer Plasticity by Maintaining Tumor Heterogeneity. Hu, Yuanjie; Ru, Ning; Xiao, Huasheng; Chaturbedi, Abhishek; Hoa, Neil T.; Tian, Xiao-Jun; Zhang, Hang; Ke, Chao; Yan, Fengrong; Nelson, Jodi; Li, Zhenzhi; Gramer, Robert; Yu, Liping; Siegel, Eric; Zhang, Xiaona; Jia, Zhenyu; Jadus, Martin R.; Limoli, Charles L.; Linskey, Mark E.; Xing, Jianhua // PLoS ONE;Nov2013, Vol. 8 Issue 11, p1 

    Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 (Chr7) copy number variation (CNV) in gliomas and in primary cultures derived from them. We found tumor heterogeneity with cells having Chr7-CNV commonly occurs in gliomas, with a higher percentage of cells in...

  • In vitro angiogenesis by human umbilical vein endothelial cells (HUVEC) induced by three-dimensional co-culture with glioblastoma cells. Zhijian Chen; Andre Htay; Wagner Santos; Milton Sholley; William Broaddus // Journal of Neuro-Oncology;Apr2009, Vol. 92 Issue 2, p121 

    Abstract  Glioblastoma multiforme (GBM) is one of the most highly vascularized of all human tumors. Our objective was to characterize a 3-dimensional (3-D) in vitro angiogenesis model by co-culturing HUVEC and GBM cells, and to study the role of VEGF in mediating capillary tubule...

  • Elevation of osteopontin levels in brain tumor cells reduces burden and promotes survival through the inhibition of cell dispersal. Stephen Selkirk; Jay Morrow; Tara Barone; Alan Hoffer; Jeffrey Lock; Anne DeChant; Saisho Mangla; Robert Miller // Journal of Neuro-Oncology;Feb2008, Vol. 86 Issue 3, p285 

    Abstract  Osteopontin (OPN) is a pleotrophic molecule that has been associated with multiple disorders of the central nervous system (CNS). Its roles in CNS malignancy are unclear but suggest that higher levels of OPN expression correlate with increased tumor grade and increased migratory...

  • Establishment of human embryonic stem cell lines from frozen–thawed blastocysts using STO cell feeder layers. Se-Pill Park; Young Jae Lee; Keum Sil Lee; Hyun Ah Shin; Hwang Yoon Cho; Kil Saeng Chung; Eun Young Kim; Jin Ho Lim // Human Reproduction;Vol. 19 Issue 3, p676 

    BACKGROUND: Recently, human embryonic stem (hES) cells have become very important resources for basic research on cell replacement therapy and other medical applications. The purpose of this study was to test whether pluripotent hES cell lines could be successfully derived from...

  • Glaucocalyxin A, a negative Akt regulator, specifically induces apoptosis in human brain glioblastoma U87MG cells. Xiao, Xian; Cao, Weidong; Jiang, Xiaofan; Zhang, Wei; Zhang, Yongqiang; Liu, Bolin; Cheng, Jinxiang; Huang, Huiyong; Huo, Junli; Zhang, Xiang // Acta Biochimica et Biophysica Sinica;Nov2013, Vol. 45 Issue 11, p946 

    Akt is becoming an attractive target in the development of anti-tumor agents. In the present study, we aimed to discover novel negative Akt regulators against malignant glioma. An Akt regulator screening platform performed in an Akt-GFP overexpression cell line was developed, and natural product...

  • Glioma Cell Proliferation Controlled by ERK Activity-Dependent Surface Expression of PDGFRA. Chen, Dongfeng; Zuo, Duo; Luan, Cheng; Liu, Min; Na, Manli; Ran, Liang; Sun, Yingyu; Persson, Annette; Englund, Elisabet; Salford, Leif G.; Renström, Erik; Fan, Xiaolong; Zhang, Enming // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

    Increased PDGFRA signaling is an essential pathogenic factor in many subtypes of gliomas. In this context the cell surface expression of PDGFRA is an important determinant of ligand sensing in the glioma microenvironment. However, the regulation of spatial distribution of PDGFRA in glioma cells...

  • Abnormal Proliferation and Aging of Cultured Fibroblasts From Pigs With Subcutaneous Fibrosis Induced by Gamma Irradiation. Martin, Michele; Remy, Jacques; Daburon, Francois // Journal of Investigative Dermatology;Oct89, Vol. 93 Issue 4, p497 

    In vivo, fibrotic disorders, which may be due either to injury or disease, are characterized by overproliferation of fibroblasts and overproduction of connective tissue. In vitro, however, most of the fibrotic cell lines studied exhibited no differences in growth potential compared with control...

  • Preliminary report on the development and characterization of rabbit clitoral smooth muscle cell culture. Sadeghi-Nejad, H.; Moreland, R.B.; Traish, A.M.; Nehra, A.; Azadzoi, K.M.; Goldstein, I. // International Journal of Impotence Research;1998, Vol. 10 Issue 3, p165 

    Purpose: Scientific model systems for physiological evaluation and investigation of pathophysiologies in clitoral function have been limited. The aim was to develop a New Zealand White rabbit clitoral corpus cavernosum smooth muscle cell culture. Methods: Clitoral corpus cavernosum erectile...

  • Hypoxia-induced expression of VE-cadherin and filamin B in glioma cell cultures and pseudopalisade structures. Nissou, Marie-France; Atifi, Michèle; Guttin, Audrey; Godfraind, Catherine; Salon, Caroline; Garcion, Emmanuel; Sanden, Boudewijn; Issartel, Jean-Paul; Berger, François; Wion, Didier // Journal of Neuro-Oncology;Jul2013, Vol. 113 Issue 2, p239 

    Most of our knowledge regarding glioma cell biology comes from cell culture experiments. For many years the standards for glioma cell culture were the use of cell lines cultured in the presence of serum and 20 % O2. However, in vivo, normoxia in many brain areas is in close to 3 % O2. Hence, in...

  • Generation of a human embryonic stem cell line encoding the cystic fibrosis mutation δF508, using preimplantation genetic diagnosis. Pickering, Susan J.; Minger, Stephen L.; Patel, Minal; Taylor, Hannah; Black, Cheryl; Burns, Chris J.; Ekonomou, Antigoni; Braude, Peter R. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Mar2005, Vol. 10 Issue 3, p390 

    Human embryonic stem (hES) cells are pluripotent cells isolated from early human embryos. They can be grown in vitro and made to differentiate into many different cell types. These properties have suggested that they may be useful in cell replacement therapy for many degenerative diseases....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics