Dimerization of inositol monophosphatase Mycobacterium tuberculosis SuhB is not constitutive, but induced by binding of the activator Mg2+

January 2007
BMC Structural Biology;2007, Vol. 7, p55
Academic Journal
No abstract available.


Related Articles

  • Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis. Movahedzadeh, Farahnaz; Wheeler, Paul R.; Dinadayala, Premkumar; Av-Gay, Yossef; Parish, Tanya; Daffé, Mamadou; Stoker, Neil G. // BMC Microbiology;2010, Vol. 10, p50 

    Background: Mycobacteria use inositol in phosphatidylinositol, for anchoring lipoarabinomannan (LAM),lipomannan (LM) and phosphatidylinosotol mannosides (PIMs) in the cell envelope, and for the production ofmycothiol, which maintains the redox balance of the cell. Inositol is synthesized by...

  • The Rhizobium leguminosarum bv. trifolii pssB gene product is an inositol monophosphatase that influences exopolysaccharide synthesis. Janczarek, Monika; Skorupska, Anna // Archives of Microbiology;Feb20001, Vol. 175 Issue 2, p143 

    The pssB gene of Rhizobium leguminosarum bv. trifolii encodes a protein of 284 amino acids with sequence similarity to eukaryotic inositol monophosphatases. The gene was cloned and overexpressed in Escherichia coli. The purified gene product of pssB showed inositol monophosphatase activity with...

  • In silico study on the substrate binding manner in human myo-inositol monophosphatase 2. Fujita, Seisuke; Ohnishi, Tetsuo; Okuda, Shujiro; Kobayashi, Ryo; Fukuno, Satoshi; Furuta, Daisuke; Kikuchi, Takeshi; Yoshikawa, Takeo; Fujita, Norihisa // Journal of Molecular Modeling;Oct2011, Vol. 17 Issue 10, p2559 

    The human IMPA2 gene encoding myo-inositol monophosphatase 2 is highly implicated with bipolar disorder but the substrates and the reaction mechanism of myo-inositol monophosphatase 2 have not been well elucidated.9 In the present study, we constructed 3D models of three- and two-Mg-ion bound...

  • Mycobacterium tuberculosis Cell Division Protein, FtsE, is an ATPase in Dimeric Form. Mondal, Sukanta; Rajeswari, Haryadi; Mir, Mushtaq; Ramakumar, Suryanarayanarao; Arumugam, Muthu; Ajitkumar, Parthasarathi // Protein Journal;Feb2015, Vol. 34 Issue 1, p35 

    FtsE is one of the earliest cell division proteins that assembles along with FtsX at the mid-cell site during cell division in Escherichia coli. Both these proteins are highly conserved across diverse bacterial genera and are predicted to constitute an ABC transporter type complex, in which FtsE...

  • Functional identification of sll1383 from Synechocystis sp PCC 6803 as L- myo-inositol 1-phosphate phosphatase (EC molecular cloning, expression and characterization. Patra, Barunava; Ghosh Dastidar, Krishnarup; Maitra, Susmita; Bhattacharyya, Jyotirmoy; Majumder, Arun // Planta;Apr2007, Vol. 225 Issue 6, p1547 

    The genome sequence of the cyanobacterium Synechocystis sp. PCC6803 revealed four Open reading frame (ORF) encoding putative inositol monophosphatase or inositol monophosphatase-like proteins. One of the ORFs, sll1383, is ∼870 base pair long and has been assigned as a probable myo-inositol...

  • Safety of Etanercept: Infectious Complications and Tuberculosis in the Treatment of Rheumatic Disease. Romero-Mat�, Alberto // Current Medical Literature: Rheumatology;2009, Vol. 28 Issue 1, following p10 

    The article reviews cases illustrating etanercept-induced risk of infections in patients with rheumatic disease. The mechanism of action and components of etanercept, a dimeric fusion protein binds, are discussed in detail. Findings of clinical studies of incidence of bacterial infections during...

  • Crystal Structure of Fad35R from Mycobacterium tuberculosis H37Rv in the Apo-State. Singh, Appu Kumar; Manjasetty, Babu; GL, Balasubramani; Koul, Sukirte; Kaushik, Abhishek; Ekka, Mary Krishna; Singh, Vijay; Kumaran, S. // PLoS ONE;May2015, Vol. 10 Issue 5, p1 

    Fad35R from Mycobacterium tuberculosis binds to the promoter site of Fad35 operon and its DNA binding activities are reduced in the presence of tetracycline and palmitoyl-CoA. We resolved the crystal structure of Fad35R using single-wavelength anomalous diffraction method (SAD). Fad35R comprises...

  • A safe lithium mimetic for bipolar disorder. Singh, Nisha; Halliday, Amy C.; Thomas, Justyn M.; Kuznetsova, Olga V.; Baldwin, Rhiannon; Woon, Esther C. Y.; Aley, Parvinder K.; Antoniadou, Ivi; Sharp, Trevor; Vasudevan, Sridhar R.; Churchill, Grant C. // Nature Communications;Jan2013, Vol. 4 Issue 1, p1332 

    Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic at only twice the therapeutic dosage and has many undesirable side effects. It is likely that a small molecule could be found with lithium-like efficacy but without toxicity through target-based...

  • Mycobacterium tuberculosis Universal Stress Protein Rv2623 Regulates Bacillary Growth by ATP-Binding: Requirement for Establishing Chronic Persistent Infection. Drumm, Joshua E.; Kaixia Mi; Bilder, Patrick; Meihao Sun; Jihyeon Lim; Bielefeldt-Ohmann, Helle; Basaraba, Randall; So, Melvin; Guofeng Zhu; Tufariello, JoAnn M.; Izzo, Angelo A.; Orme, Ian M.; Almo, Steve C.; Leyh, Thomas S.; Chan, John // PLoS Pathogens;May2009, Vol. 5 Issue 5, p1 

    Tuberculous latency and reactivation play a significant role in the pathogenesis of tuberculosis, yet the mechanisms that regulate these processes remain unclear. The Mycobacterium tuberculosis universal stress protein (USP) homolog, rv2623, is among the most highly induced genes when the...

  • Characterization of a Novel ArsR-Like Regulator Encoded by Rv2034 in Mycobacterium tuberculosis. Chun-hui Gao; Min Yang; Zheng-Guo He // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    The genome of Mycobacterium tuberculosis, the causative agent of tuberculosis, encodes a large number of putative transcriptional regulators. However, the identity and target genes of only a few of them have been clearly identified to date. In a recent study, the ArsR family regulator Rv2034 was...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics