Perfusion computed tomography in colorectal cancer: Protocols, clinical applications and emerging trends

Guang-Yao Wu; Ghimire, Prasanna; Yik-Hong Ho
July 2009
World Journal of Gastroenterology;7/14/2009, Vol. 15 Issue 26, p3228
Academic Journal
Perfusion computed tomography (CT) has emerged as a novel functional imaging technique with gradually increasing importance in the management of colorectal cancer (CRC). By providing the functional tumor microvasculature, it also helps the assessment of therapeutic response of anti-angiogenic drugs as it may reflect tumor angiogenesis. Perfusion CT has been applied in clinical practice to delineate inflammatory or neoplastic lymph nodes irrespective of their size, identify micro-metastases and to predict metastases in advance of their development. It is of increasing significance for preoperative adjuvant therapies and avoidance of unnecessary interventions. Despite controversies regarding the techniques employed, its validity and reproducibility, it can be advantageous in the management of CRCs in which the prognosis is dependent on preoperative staging. With recent advances in the perfusion CT techniques, and incorporation to other modalities like positron emission tomography, perfusion CT will be a novel tool in the overall management of CRCs. This article aims at reviewing the existing clinical applications and recent advances of perfusion CT with a reference to future development in the management of CRCs.


Related Articles

  • Is the lymph node ratio superior to the Union for International Cancer Control (UICC) TNM system in prognosis of colon cancer? Schiffmann, Leif; Eiken, Anne Karen; Gock, Michael; Klar, Ernst // World Journal of Surgical Oncology;2013, Vol. 11 Issue 1, Special section p1 

    Background: Decision making for adjuvant chemotherapy in stage III colon cancer is based on the TNM system. It is well known that prognosis worsens with higher pN classification, and several recent studies propose superiority of the lymph node ratio (ln ratio) to the TNM system. Therefore, we...

  • Relationship and prognostic significance of SPARC and VEGF protein expression in colon cancer. Jian-fang Liang; Hong-kun Wang; Hong Xiao; Ning Li; Cai-xia Cheng; Yu-ze Zhao; Yan-bo Ma; Jian-zhong Gao; Rui-bing Bai; Hui-xia Zheng // Journal of Experimental & Clinical Cancer Research (17569966);2010, Vol. 29, p71 

    Background: SPARC (secreted protein, acidic and rich in cysteine) is closely related with the progress, invasion and metastasis of malignant tumor and angiogenesis. Methods: Using human colon adenocarcinoma tissues (hereinafter referred to as colon cancer) and their corresponding non-diseased...

  • Long-term prognosis of video-assisted limited surgery for early lung cancer Sugi, Kazuro; Kobayashi, Seiki; Sudou, Manabu; Sakano, Hisashi; Matsuda, Eisuke; Okabe, Kazunori // European Journal of Cardio-Thoracic Surgery;Feb2010, Vol. 37 Issue 2, p456 

    Abstract: Objective: The present intervention study was conducted to prospectively evaluate the long-term prognosis for video-assisted limited surgery, such as wedge resection and segmentectomy, for clinically early lung cancers depending on findings in high-resolution computed tomography...

  • Lymph Node Harvest in Resected Colon Cancer Specimens. Kiss, R.; Kiss, L.; Chis, F.; Ilie, S.; Porr, p.; Alexe, D.; Maniu, D.; Mitachescu, S.; Zaharia, I. // Acta Medica Marisiensis;Jan2011, Vol. 57 Issue 1, p34 

    Background: The number of lymph nodes evaluated may be a measure of quality in colon cancer care and appears to be inadequate in most patients treated for colon cancer. We performed a systematic review of the evidence for the association between lymph node evaluation and oncologic outcomes in...

  • Lymph Node Ratio Improves TNM and Astler-Coller's Assessment of Colorectal Cancer Prognosis: an Analysis of 761 Node Positive Cases. Costi, Renato; Beggi, Filippo; Reggiani, Valeria; Riccò, Matteo; Crafa, Pellegrino; Bersanelli, Melissa; Tartamella, Francesco; Violi, Vincenzo; Roncoroni, Luigi; Sarli, Leopoldo // Journal of Gastrointestinal Surgery;Oct2014, Vol. 18 Issue 10, p1824 

    Background: Prognosis assessment of node-positive colorectal cancer patients by Astler-Coller (AC) and TNM classifications is suboptimal. Recently, several versions of lymph node ratio (LNR; ratio metastatic/examined nodes) have been proposed but are still mostly unused. Methods: The prognostic...

  • Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer. Ishikawa, K.; Kamohara, Y.; Tanaka, F.; Haraguchi, N.; Mimori, K.; Inoue, H.; Mori, M. // British Journal of Cancer;6/3/2008, Vol. 98 Issue 11, p1824 

    Mitotic centromere-associated kinesin (MCAK) is a microtubule depolymerase that is essential for proper kinetochore-microtubule attachment during spindle formation. Overexpression of MCAK has been correlated with aggressive forms of carcinoma, resulting in poor prognosis of colorectal cancer....

  • ACCENT-Based Web Calculators to Predict Recurrence and Overall Survival in Stage III Colon Cancer. Renfro, Lindsay A.; Grothey, Axel; Yuan Xue; Saltz, Leonard B.; AndrĂ©, Thierry; Twelves, Chris; Labianca, Roberto; Allegra, Carmen J.; Alberts, Steven R.; Loprinzi, Charles L.; Yothers, Greg; Sargent, Daniel J. // JNCI: Journal of the National Cancer Institute;12/10/2014, Vol. 106 Issue 12, p1 

    Background Current prognostic tools in colon cancer use relatively few patient characteristics. We constructed and validated clinical calculators for overall survival (OS) and time to recurrence (TTR) for stage III colon cancer and compared their performance against an existing tool (Numeracy)...

  • P-0213TUMOR-STROMA LYMPH NODE INVOLVEMENT IS A HETEROGENEOUS PROCESS AND ADDS TO PROGNOSIS FOR STAGE III COLON CANCER PATIENTS. Van Pelt, Gabi; Smit, Vincent; Gelderblom, Hans; Van Krieken, Han; Tollenaar, Rob; Mesker, Wilma // Annals of Oncology;Jun2013, Vol. 24 Issue suppl_4, piv96 

    No abstract available.

  • Can perfusion CT assessment of primary colorectal adenocarcinoma blood flow at staging predict for subsequent metastatic disease? A pilot study. Goh, Vicky; Halligan, Steve; Wellsted, David M.; Bartram, Clive I. // European Radiology;Jan2009, Vol. 19 Issue 1, p79 

    We aimed to determine whether perfusion CT measurements at colorectal cancer staging may predict for subsequent metastatic relapse. Fifty two prospective patients underwent perfusion CT at staging to estimate tumour blood flow, blood volume, mean transit time, and permeability surface area...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics