TITLE

Potential of Microvascular Reperfusion with Adjunctive Pharmacological Intervention: Its Impact on Myocardial Perfusion and Functional Outcomes in Patients with Acute Myocardial Infarction

AUTHOR(S)
Taniyama, Y.; Ito, H.; Morishita, R.; Ogihara, T.
PUB. DATE
February 2001
SOURCE
Drugs;Feb2001, Vol. 61 Issue 4, p437
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
One of the major limitations of reperfusion therapy in acute myocardial infarction (AMI) is the presentation of no-reflow phenomenon. In 25 to 30% of patients with AMI, myocardial blood flow is occasionally profoundly reduced, even after coronary recanalisation, because of microvascular dysfunction - so-called no-reflow phenomenon. Patients with this phenomenon are regarded as a high risk group among patients with reperfused AMI. Clinical studies using myocardial contrast echocardiography have demonstrated that intracoronary injection of calcium antagonists or potassium channel agonists in conjunction with coronary reperfusion can augment myocardial blood flow and that this was associated with better functional and clinical outcomes than with percutaneous transluminal coronary angioplasty alone. Thus, it is possible to prevent reperfusion injury and improve cardiac function using a adjunctive pharmacological intervention, either intravenously or by infusion directly into the coronary artery.
ACCESSION #
4369357

 

Related Articles

  • Heartbeat: Highlights from the issue. Ribeiro, Antonio Luiz; Otto, Catherine M. // Heart;Jul2015, Vol. 101 Issue 13, p991 

    An introduction is presented in which the editor discusses various reports within the issue on topics including lower long-term mortality in the hospitalized Acute Myocardial Infarction (AMI) patients, estimated reperfusion time, and ability of a novel accelerated diagnostic protocol (ADP).

  • Reperfusion injury after acute myocardial infarction. Grech, Ever D.; Jackson, Malcolm J. // BMJ: British Medical Journal (International Edition);2/25/95, Vol. 310 Issue 6978, p477 

    Looks into the adverse effects of reperfusion after an acute myocardial infarction. Vulnerability to arrhythmias; Possibilities of myocardial stunning; Lethal myocyte injury.

  • Other clinicians play a part in expediting reperfusion. Quinn, T. // Emergency Medicine Journal;Feb2008, Vol. 25 Issue 2, p122 

    A letter to the editor is presented in response to the article on the review of the changing nature of reperfusion in acute ST elevation myocardial infarction.

  • Reperfusion Therapy for Acute Myocardial Infarction. Aylward,, Phil; Aylward, Philip; Hunt, David; Australia, the Medical Issues Committee of the National Heart Foundation of // Heart, Lung & Circulation;Oct2001, Vol. 10 Issue 2, p99 

    The following National Heart Foundation of Australia (NHFA) guidelines are intended to assist physicians and other health-care providers in the appropriate management of patients presenting with acute myocardial infarction with ST elevation requiring reperfusion therapy. The guidelines describe...

  • Reperfusion is effective for most patients with acute MI.  // Modern Medicine;Oct97, Vol. 65 Issue 10, p55 

    Presents an abstract of the article entitled `Can We Provide Reperfusion Therapy to All Unselected Patients Admitted With Acute Myocardial Infarction?,' by J.M. Juliard, D. Himbert et al published in the July 1997 issue of the `American Journal of the College of Cardiology.'

  • Limitations of the electrocardiogram in estimating infarction size after acute reperfusion therapy for myocardial infarction. Christian, Timothy F.; Clements, Ian P.; Behrenbeck, Thomas; Huber, Kenneth C.; Chesebro, James H.; Gersh, Bernard J.; Gibbons, Raymond J.; Christian, T F; Clements, I P; Behrenbeck, T; Huber, K C; Chesebro, J H; Gersh, B J; Gibbons, R J // Annals of Internal Medicine;2/15/91, Vol. 114 Issue 4, p264 

    Objective: To assess the ability of the 12-lead electrocardiogram to estimate infarction size after reperfusion therapy for acute myocardial infarction. Design: The presence or absence of Q waves and the Selvester QRS score obtained before and after hospital discharge...

  • Early Definition of Treatment Outcomes After Reperfusion Therapy for Myocardial Infarction. Zhang, Yi; Patel, Anushka; Jeremy, Richmond W. // Heart, Lung & Circulation;Mar2004, Vol. 13 Issue 1, p31 

    Aims. Early definition of treatment outcomes, including coronary patency and infarct size, after reperfusion therapy for myocardial infarction (MI) is desirable to identify patients requiring further intervention.Methods and Results. Patients receiving reperfusion therapy for a first MI had...

  • A Decision Aid for Recognizing and Treating Heart Attacks Quickly.  // Annals of Internal Medicine;7/16/2002, Vol. 137 Issue 2, p24 

    Examines the use of electrocardiograph-based thrombolytic and reperfusion therapy for acute myocardial infarction. Percentage of respondents given thrombolytic therapy and who had angioplasty; Increase in the use of thrombolytic therapy with the use of a decision aid; Limitations of the study.

  • Outcome of Patients Sustaining Acute Ischemic Mitral Regurgitation during Myocardial Infarction. Tcheng, James E.; Jackman, John D.; Nelson, Charlotte L.; Gardner, Laura H.; Smith, L. Richard; Rankin, J. Scott; Califf, Robert M.; Stack, Richard S. // Annals of Internal Medicine;7/1/92, Vol. 117 Issue 1, p18 

    Describes the outcomes of patients sustaining an acute myocardial infarction complicated by mitral regurgitation managed with contemporary reperfusion therapies. Patients; Methods; Results and discussion.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics