Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates

January 2007
BMC Genomics;2007, Vol. 8, p45
Academic Journal
No abstract available.


Related Articles

  • Evolutionarily conserved pattern of gene segment usage within the mammalian TCRβ locus. Livák, Ferenc // Immunogenetics;Aug2003, Vol. 55 Issue 5, p307 

    Antigen receptor gene rearrangement is mediated by interactions between the VDJ recombinase and the recombination signal sequences that flank the antigen receptor gene segments. In this report I present phylogenetic analyses that suggest a remarkable evolutionary conservation of the...

  • Sympatric Plasmodium falciparum isolates from Venezuela have structured var gene repertoires. Tami, Adriana; Ord, Rosalynn; Targett, Geoffrey A. T.; Sutherland, Colin J. // Malaria Journal;2003, Vol. 2, p1 

    Background: The human malaria parasite Plasmodium falciparum expresses adhesins belonging to the erythrocyte membrane protein 1 (PfEMP1) family on the surface of the infected host erythrocyte. These antigens elicit a strain-specific antibody response that is associated with protection from...

  • Population Genomics of the Immune Evasion (var) Genes of Plasmodium falciparum. Barry, Alyssa E.; Leliwa-Sytek, Aleksandra; Tavul, Livingston; Imrie, Heather; Migot-Nabias, Florence; Brown, Stuart M.; McVean, Gilean A. V.; Day, Karen P. // PLoS Pathogens;Mar2007, Vol. 3 Issue 3, p0349 

    Var genes encode the major surface antigen (PfEMP1) of the blood stages of the human malaria parasite Plasmodium falciparum. Differential expression of up to 60 diverse var genes in each parasite genome underlies immune evasion. We compared the diversity of the DBLα domain of var genes...

  • Cloning of the Repertoire of Individual Plasmodium falciparum var Genes Using Transformation Associated Recombination (TAR). Gaida, Annette; Becker, Marion M.; Schmid, Christoph D.; Bühlmann, Tobias; Louis, Edward J.; Beck, Hans-Peter // PLoS ONE;2011, Vol. 6 Issue 3, p1 

    One of the major virulence factors of the malaria causing parasite is the Plasmodium falciparum encoded erythrocyte membrane protein 1 (PfEMP1). It is translocated to It the membrane of infected erythrocytes and expressed from approximately 60 var genes in a mutually exclusive manner. Switching...

  • Evolution of the Multi-Domain Structures of Virulence Genes in the Human Malaria Parasite, Plasmodium falciparum. Buckee, Caroline O.; Recker, Mario // PLoS Computational Biology;Apr2012, Vol. 8 Issue 4, p1 

    The var gene family of Plasmodium falciparum encodes the immunodominant variant surface antigens PfEMP1. These highly polymorphic proteins are important virulence factors that mediate cytoadhesion to a variety of host tissues, causing sequestration of parasitized red blood cells in vital organs,...

  • Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions. Lavstsen, Thomas; Salanti, Ali; Jensen, Anja T. R.; Arnot, David E.; Theander, Thor G. // Malaria Journal;2003, Vol. 2, p1 

    Background: The variant surface antigen family Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. The sequence diversity and...

  • The effects of a partitioned var gene repertoire of Plasmodium falciparum on antigenic diversity and the acquisition of clinical immunity. Recker, Mario; Arinaminpathy, Nimalan; Buckee, Caroline O. // Malaria Journal;2008, Vol. 7, Special section p1 

    Background: The human malaria parasite Plasmodium falciparum exploits antigenic diversity and within-host antigenic variation to evade the host's immune system. Of particular importance are the highly polymorphic var genes that encode the family of cell surface antigens PfEMP1 (Plasmodium...

  • Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria. Mugasa, Joseph; Weihong Qi; Rusch, Sebastian; Rottmann, Matthias; Beck, Hans-Peter // Malaria Journal;2012, Vol. 11 Issue 1, p230 

    Background: Severe malaria has been attributed to the expression of a restricted subset of the var multi-gene family, which encodes for Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 mediates cytoadherence and sequestration of infected erythrocytes into the post-capillary...

  • Hypervariable antigen genes in malaria have ancient roots. Zilversmit, Martine M.; Chase, Ella K.; Chen, Donald S.; Awadalla, Philip; Day, Karen P.; McVean, Gil // BMC Evolutionary Biology;2013, Vol. 13 Issue 1, p1 

    Background: The var genes of the human malaria parasite Plasmodium falciparum are highly polymorphic loci coding for the erythrocyte membrane proteins 1 (PfEMP1), which are responsible for the cytoaherence of P. falciparum infected red blood cells to the human vasculature. Cytoadhesion, coupled...

  • Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression. Bachmann, Anna; Bruske, Ellen; Krumkamp, Ralf; Turner, Louise; Wichers, J. Stephan; Petter, Michaela; Held, Jana; Duffy, Michael F.; Sim, B. Kim Lee; Hoffman, Stephen L.; Kremsner, Peter G.; Lell, Bertrand; Lavstsen, Thomas; Frank, Matthias; Mordmüller, Benjamin; Tannich, Egbert // PLoS Pathogens;7/11/2019, Vol. 15 Issue 7, p1 

    The pathogenesis of Plasmodium falciparum malaria is linked to the variant surface antigen PfEMP1, which mediates tethering of infected erythrocytes to the host endothelium and is encoded by approximately 60 var genes per parasite genome. Repeated episodes of malaria infection result in the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics