Genome-wide mapping of ORC and Mcm2p binding sites on tiling arrays and identification of essential ARS consensus sequences in S. cerevisiae

January 2006
BMC Genomics;2006, Vol. 7, p276
Academic Journal
No abstract available.


Related Articles

  • Genome-Wide Prediction and Validation of Sigma70 Promoters in Lactobacillus plantarum WCFS1. Todt, Tilman J.; Wels, Michiel; Bongers, Roger S.; Siezen, Roland S.; Van Hijum, Sacha A. F. T.; Kleerebezem, Michiel; Qing Song // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    Background: In prokaryotes, sigma factors are essential for directing the transcription machinery towards promoters. Various sigma factors have been described that recognize, and bind to specific DNA sequence motifs in promoter sequences. The canonical sigma factor σ70 is commonly involved in...

  • A ~35 kDa polypeptide from insect cells binds to yeast ACS like elements in the presence of ATP. Dhar, Suman K.; Mondal, Neelima; Soni, Rajesh K.; Mukhopadhyay, Gauranga // BMC Biochemistry;2002, Vol. 3, p23 

    Background: The S. cerevisiae origin recognition complex binds to the ARS consensus sequence in an ATP dependent fashion. Recently, the yeast Cdc6 has been reported to have DNA binding activity. Conservation of replication proteins among different species strongly supports their functional...

  • HAT: Hypergeometric Analysis of Tiling-arrays with application to promoter-GeneChip data. Taskesen, Erdogan; Beekman, Renee; de Ridder, Jeroen; Wouters, Bas J.; Peeters, Justine K.; Touw, Ivo P.; Reinders, Marcel J. T.; Delwel, Ruud // BMC Bioinformatics;2010, Vol. 11, p275 

    Background: Tiling-arrays are applicable to multiple types of biological research questions. Due to its advantages (high sensitivity, resolution, unbiased), the technology is often employed in genome-wide investigations. A major challenge in the analysis of tiling-array data is to define...

  • The Origin Recognition Complex Interacts with a Subset of Metabolic Genes Tightly Linked to Origins of Replication. Shor, Erika; Warren, Christopher L.; Joshua Tietjen; Zhonggang Hou; Müller, Ulrika; Alborelli, Ilaria; Gohard, Florence H.; Yemm, Adrian I.; Borisov, Lev; Broach, James R.; Weinreich, Michael; Nieduszynski, Conrad A.; Ansari, Aseem Z.; Fox, Catherine A. // PLoS Genetics;Dec2009, Vol. 5 Issue 12, p1 

    The origin recognition complex (ORC) marks chromosomal sites as replication origins and is essential for replication initiation. In yeast, ORC also binds to DNA elements called silencers, where its primary function is to recruit silent information regulator (SIR) proteins to establish...

  • ARS sequences in homologous and heterologous ADE2 loci are capable of promoting autonomous replication of plasmids in Schwanniomyces occidentalis. Janatova, Ivana; Gourdon, Pierre; Meilhoc, Eliane; Klein, Ronald D.; Masson, Jean-Michel // Current Genetics;May2000, Vol. 37 Issue 5, p298 

    We have analyzed ARS elements linked to homologous and heterologous ADE2 loci functioning in Schwanniomyces occidentalis. We have identified a region of the ADE2 locus of S. occidentalis which promotes autonomous replication of plasmids in S. occidentalis cells. This region is within 385 bp...

  • Dose-dependent effects of small-molecule antagonists on the genomic landscape of androgen receptor binding. Zhu, Zhou; Shi, Manli; Hu, Wenyue; Estrella, Heather; Engebretsen, Jon; Nichols, Tim; Briere, David; Hosea, Natilie; Los, Gerrit; Rejto, Paul A.; Fanjul, Andrea // BMC Genomics;2012, Vol. 13 Issue 1, p355 

    Background: The androgen receptor plays a critical role throughout the progression of prostate cancer and is an important drug target for this disease. While chromatin immunoprecipitation coupled with massively parallel sequencing (ChIP-Seq) is becoming an essential tool for studying...

  • A Comprehensive Genome-Wide Map of Autonomously Replicating Sequences in a Naive Genome. Liachko, Ivan; Bhaskar, Anand; Chanmi Lee; Shau Chee Claire Chung; Bik-Kwoon Tye; Keich, Uri // PLoS Genetics;May2010, Vol. 6 Issue 5, p1 

    Eukaryotic chromosomes initiate DNA synthesis from multiple replication origins. The machinery that initiates DNA synthesis is highly conserved, but the sites where the replication initiation proteins bind have diverged significantly. Functional comparative genomics is an obvious approach to...

  • Enhancement of telomere-plasmid segregation by the X-telomere associated sequence in Saccharomyce... Enomoto, Shinichiro; Longtine, Mark S. // Genetics;Mar94, Vol. 136 Issue 3, p759 

    Demonstrates the importance of the products of SIR2, SIR3, SIR4 and ABF1 in telomere(TEL)-plasmid segregation by the X-telomere associated sequence (X-TAS) in Saccharomyces cerevisiae. Role of ABF1 in TEL-plasmid segregation; Importance of the Abf1p-binding site within the X-TAS; Role of the...

  • DNA breathing dynamics distinguish binding from nonbinding consensus sites for transcription factor YY1 in cells. Alexandrov, Boian S.; Fukuyo, Yayoi; Lange, Martin; Horikoshi, Nobuo; Gelev, Vladimir; Rasmussen, Kim Ø.; Bishop, Alan R.; Usheva, Anny // Nucleic Acids Research;Nov2012, Vol. 40 Issue 20, p10116 

    The genome-wide mapping of the major gene expression regulators, the transcription factors (TFs) and their DNA binding sites, is of great importance for describing cellular behavior and phenotypic diversity. Presently, the methods for prediction of genomic TF binding produce a large number of...

  • A Link between ORC-Origin Binding Mechanisms and Origin Activation Time Revealed in Budding Yeast. Hoggard, Timothy; Shor, Erika; Müller, Carolin A.; Nieduszynski, Conrad A.; Fox, Catherine A. // PLoS Genetics;Sep2013, Vol. 9 Issue 9, p1 

    Eukaryotic DNA replication origins are selected in G1-phase when the origin recognition complex (ORC) binds chromosomal positions and triggers molecular events culminating in the initiation of DNA replication (a.k.a. origin firing) during S-phase. Each chromosome uses multiple origins for its...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics