A multispecies comparison of the metazoan 3'-processing downstream elements and the CstF-64 RNA recognition motif

January 2006
BMC Genomics;2006, Vol. 7, p55
Academic Journal
No abstract available.


Related Articles

  • Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein. G. Varani; J.M. Pérez Cañadillas // EMBO Journal;6/1/2003, Vol. 22 Issue 11, p2821 

    Vertebrate polyadenylation sites are identified by the AAUAAA signal and by GU-rich sequences downstream of the cleavage site. These are recognized by a heterotrimeric protein complex (CstF) through its 64 kDa subunit (CstF-64); the strength of this interaction affects the efficiency of poly(A)...

  • Alternative pre-mRNA splicing and proteome expansion in metazoans. Maniatis, Tom; Tasic, Bosiljka // Nature;7/11/2002, Vol. 418 Issue 6894, p236 

    Focuses on a study regarding the role of protein coding sequences of eukaryotic messenger RNA (pre-mRNA) precursors in the expansion of metazoan proteomes during evolution. Exon recognition in spliced pre-mRNA; Mechanisms that increase protein diversity in metazoans; Regulation of alternative...

  • NTF2-like domain of Tap plays a critical role in cargo mRNA recognition and export. Katahira, Jun; Dimitrova, Lyudmila; Imai, Yumiko; Hurt, Ed // Nucleic Acids Research;Feb2015, Vol. 43 Issue 3, p1894 

    Metazoan Tap-p15 (also called Nxf1-Nxt1) and yeast Mex67-Mtr2 heterodimers are the general mRNA export receptors. The RNA binding activity of Tap-p15, which is essential for mRNA nuclear export, has been attributed to the amino-terminal RNA binding module of Tap consists of RNA recognition motif...

  • In silico characterization of a RNA binding protein of cattle filarial parasite Setaria digitata. Nagaratnam, Nirupa; Karunanayake, Eric Hamilton; Tennekoon, Kamani Hemamala; Samarakoon, Sameera Ranganath; Mayan, Karthika // Bioinformation;2014, Vol. 10 Issue 8, p512 

    Human lymphatic filariasis (HLF) is a neglected tropical disease which threatens nearly 1.4 billion people in 73 countries worldwide. Wuchereria bancrofti is the major causative agent of HLF and it closely resembles cattle filarial parasite Setaria digitata. Due to difficulties in procuring W....

  • A family of splice variants of CstF-64 expressed in vertebrate nervous systems. Shankarling, Ganesh S.; Coates, Penelope W.; Dass and, Brinda; MacDonald, Clinton C. // BMC Molecular Biology;2009, Vol. 10, Special section p1 

    Background: Alternative splicing and polyadenylation are important mechanisms for creating the proteomic diversity necessary for the nervous system to fulfill its specialized functions. The contribution of alternative splicing to proteomic diversity in the nervous system has been well...

  • Comparative genomics of small RNA regulatory pathway components in vector mosquitoes. Campbell, Corey L.; Black IV, William C.; Hess, Ann M.; Foy, Brian D. // BMC Genomics;2008, Vol. 9, Special section p1 

    Background: Small RNA regulatory pathways (SRRPs) control key aspects of development and anti-viral defense in metazoans. Members of the Argonaute family of catalytic enzymes degrade target RNAs in each of these pathways. SRRPs include the microRNA, small interfering RNA (siRNA) and PIWI-type...

  • The 3′ processing factor CstF functions in the DNA repair response. Mirkin, Nurit; Fonseca, Danae; Mohammed, Samia; Cevher, Murat A.; Manley, James L.; Kleiman, Frida E. // Nucleic Acids Research;2008, Vol. 36 Issue 6, p1792 

    Following DNA damage, mRNA levels decrease, reflecting a coordinated interaction of the DNA repair, transcription and RNA processing machineries. In this study, we provide evidence that transcription and polyadenylation of mRNA precursors are both affected in vivo by UV treatment. We next show...

  • A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked... Takagaki, Yoshio; Manley, James L. // Nature;12/1/1994, Vol. 372 Issue 6505, p471 

    Reports the cloning and characterization of the 77K subunit of human cleavage stimulation factor (CstF). Functions of the subunit; Result of sequence analyses; Sharing of homology with Saccharomyces cerevisiae RNA14.

  • Structural basis for recognition of AU-rich element RNA by the HuD protein. Wang, Xiaoqiang; Tanaka Hall, Traci M. // Nature Structural Biology;Feb2001, Vol. 8 Issue 2, p141 

    Hu proteins bind to adenosine-uridine (AU)-rich elements (AREs) in the 3′ untranslated regions of many short-lived mRNAs, thereby stabilizing them. Here we report the crystal structures of the first two RNA recognition motif (RRM) domains of the HuD protein in complex with an 11-nucleotide...

  • A compendium of RNA-binding motifs for decoding gene regulation. Ray, Debashish; Kazan, Hilal; Cook, Kate B.; Weirauch, Matthew T.; Najafabadi, Hamed S.; Li, Xiao; Gueroussov, Serge; Albu, Mihai; Zheng, Hong; Yang, Ally; Na, Hong; Irimia, Manuel; Matzat, Leah H.; Dale, Ryan K.; Smith, Sarah A.; Yarosh, Christopher A.; Kelly, Seth M.; Nabet, Behnam; Mecenas, Desirea; Li, Weimin // Nature;7/11/2013, Vol. 499 Issue 7457, p172 

    RNA-binding proteins are key regulators of gene expression, yet only a small fraction have been functionally characterized. Here we report a systematic analysis of the RNA motifs recognized by RNA-binding proteins, encompassing 205 distinct genes from 24 diverse eukaryotes. The sequence...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics