Cross genome phylogenetic analysis of human and Drosophila G protein-coupled receptors: application to functional annotation of orphan receptors

January 2005
BMC Genomics;2005, Vol. 6, p106
Academic Journal
No abstract available.


Related Articles

  • Molecular cloning of the receptor for human antidiuretic hormone. Birnbaumer, M.; Seibold, A. // Nature;5/28/1992, Vol. 357 Issue 6376, p333 

    Describes the physiological mechanism of antidiuresis and reports the isolation of the human antidiuretic hormone (ADH) receptor gene. Use of a genomic expression cloning approach; Indications that the ADH receptor is a member of the superfamily of G-protein-coupled receptors; Results of...

  • Phylogenetic investigation of peptide hormone and growth factor receptors in five dipteran genomes. Vogel, Kevin J.; Brown, Mark R.; Strand, Michael R. // Frontiers in Endocrinology;Dec2013, Vol. 4, p1 

    Peptide hormones and growth factors bind to membrane receptors and regulate a myriad of processes in insects and other metazoans. The evolutionary relationships among characterized and uncharacterized ("orphan") receptors can provide insights into receptor-ligand biology and narrow target...

  • Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data. Hauser, Frank; Williamson, Michael; Cazzamali, Giuseppe; Grimmelikhuijzen, Cornelis J. P. // Briefings in Functional Genomics & Proteomics;Feb2006, Vol. 4 Issue 4, p321 

    Most neuropeptide and protein hormone receptors belong co the large superfamily of G-protein-coupled receptors (GPCRs). These cell membrane proteins steer many important processes such as development, reproduction, homeostasis and behaviour when activated by their corresponding ligands. The...

  • The Gr Family of Candidate Gustatory and Olfactory Receptors in the Yellow-Fever Mosquito Aedes aegypti. Kent, Lauren B.; Walden, Kimberly K.O.; Robertson, Hugh M. // Chemical Senses;Jan2008, Vol. 33 Issue 1, p79 

    The gustatory receptor (Gr) protein family contains most of the diversity in the insect chemoreceptor superfamily, including within it not only taste receptors but select olfactory receptors as well. Manual annotation of the Gr family in the genome sequence of the yellow-fever mosquito, Aedes...

  • Seven-transmembrane-spanning receptors and heart function. Rockman, Howard A.; Koch, Walter J.; Lefkowitz, Robert J. // Nature;1/10/2002, Vol. 415 Issue 6868, p206 

    Investigates the complex interactions that occur between the receptors and the signalling pathways of the heart. Concepts of receptor regulation; Analysis of the G-protein-coupled receptor; Effect of beta-blockade on cardiac function.

  • AChemS XXII Symposium: Olfaction in Drosophila: Coding, Genetics and e-Genetics.  // Chemical Senses;Feb2001, Vol. 26 Issue 2, p201 

    The article discusses the cellular basis of odor coding in Drosophila. It examines the individual functions of olfactory receptor neurons (ORNs) using a single-unit electrophysiology. It states that electronic-genetics was used to identify the odor receptors in Drosophila, and assumed that...

  • An automated algorithm for extracting functional immunologic V-genes from genomes in jawed vertebrates. Olivieri, David; Faro, Jose; Haeften, Bernardo; Sánchez-Espinel, Christian; Gambón-Deza, Francisco // Immunogenetics;Sep2013, Vol. 65 Issue 9, p691 

    Variable (V) domains of immunoglobulins (Ig) and T cell receptors (TCR) are generated from genomic V gene segments (V-genes). At present, such V-genes have been annotated only within the genome of a few species. We have developed a bioinformatics tool that accelerates the task of identifying...

  • Dynamic Resource Allocation in Disaster Response: Tradeoffs in Wildfire Suppression. Petrovic, Nada; Alderson, David L.; Carlson, Jean M. // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    Challenges associated with the allocation of limited resources to mitigate the impact of natural disasters inspire fundamentally new theoretical questions for dynamic decision making in coupled human and natural systems. Wildfires are one of several types of disaster phenomena, including oil...

  • Characterisation of Bovine Leukocyte Ig-like Receptors. Hogan, Louise; Bhuju, Sabin; Jones, Des C.; Laing, Ken; Trowsdale, John; Butcher, Philip; Singh, Mahavir; Vordermeier, Martin; Allen, Rachel L. // PLoS ONE;Apr2012, Vol. 7 Issue 4, p1 

    Leukocyte Immunoglobulin-like receptors (LILR) are innate immune receptors involved in regulating both innate and adaptive immune functions. LILR show more interspecies conservation than the closely related Killer Ig-like receptors, and homologues have been identified in rodents, primates, seals...

  • AChemS XXII Symposium: The Molecular Logic of Olfaction in Drosophila.  // Chemical Senses;Feb2001, Vol. 26 Issue 2, p207 

    The article discusses the identification of olfactory receptor molecules in Drosophila. It examines the odorant receptor molecules through the complimentary approach of differential cloning and genome analysis of Drosophila odorant receptor (DOR) genes. It notes that the double in situ RNA...


Other Topics