TITLE

Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture

PUB. DATE
January 2007
SOURCE
BMC Genetics;2007, Vol. 8, p66
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
43678388

 

Related Articles

  • A mutation in the serine protease TMPRSS4 in a novel pediatric neurodegenerative disorder. Lahiry, Piya; Racacho, Lemuel; Jian Wang; Robinson, John F.; Gloor, Gregory B.; Anthony Rupar, C.; Siu, Victoria M.; Bulman, Dennis E.; Hegele, Robert A. // Orphanet Journal of Rare Diseases;2013, Vol. 8 Issue 1, p1 

    Background: To elucidate the genetic basis of a novel neurodegenerative disorder in an Old Order Amish pedigree by combining homozygosity mapping with exome sequencing. Methods and results: We identified four individuals with an autosomal recessive condition affecting the central nervous system...

  • Genetic Mapping and Exome Sequencing Identify Variants Associated with Five Novel Diseases. Puffenberger, Erik G.; Jinks, Robert N.; Sougnez, Carrie; Cibulskis, Kristian; Willert, Rebecca A.; Achilly, Nathan P.; Cassidy, Ryan P.; Fiorentini, Christopher J.; Heiken, Kory F.; Lawrence, Johnny J.; Mahoney, Molly H.; Miller, Christopher J.; Nair, Devika T.; Politi, Kristin A.; Worcester, Kimberly N.; Setton, Roni A.; DiPiazza, Rosa; Sherman, Eric A.; Eastman, James T.; Francklyn, Christopher // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    The Clinic for Special Children (CSC) has integrated biochemical and molecular methods into a rural pediatric practice serving Old Order Amish and Mennonite (Plain) children. Among the Plain people, we have used single nucleotide polymorphism (SNP) microarrays to genetically map recessive...

  • A Systematic Approach to Mapping Recessive Disease Genes in Individuals from Outbred Populations. Hildebrandt, Friedhelm; Heeringa, Saskia F.; R├╝schendorf, Franz; Attanasio, Massimo; N├╝rnberg, Gudrun; Becker, Christian; Seelow, Dominik; Huebner, Norbert; Chernin, Gil; Vlangos, Christopher N.; Weibin Zhou; O'Toole, John F.; Hoskins, Bethan E.; Wolf, Matthias T. F.; Hinkes, Bernward G.; Chaib, Hassan; Ashraf, Shazia; Schoeb, Dominik S.; Ovunc, Bugsu; Allen, Susan J. // PLoS Genetics;Jan2009, Vol. 5 Issue 1, p1 

    The identification of recessive disease-causing genes by homozygosity mapping is often restricted by lack of suitable consanguineous families. To overcome these limitations, we apply homozygosity mapping to single affected individuals from outbred populations. In 72 individuals of 54 kindred...

  • The sex-specific genetic architecture of quantitative traits in humans. Weiss, Lauren A.; Lin Pan; Abney, Mark; Ober, Carole // Nature Genetics;Feb2006, Vol. 38 Issue 2, p218 

    Mapping genetically complex traits remains one of the greatest challenges in human genetics today. In particular, gene-environment and gene-gene interactions, genetic heterogeneity and incomplete penetrance make thorough genetic dissection of complex traits difficult, if not impossible. Sex...

  • Familial Aggregation of Tobacco Use Behaviors Among Amish Men. Nugent, Katie L.; Million-Mrkva, Amber; Backman, Joshua; Stephens, Sarah H.; Reed, Robert M.; Kochunov, Peter; Pollin, Toni I.; Shuldiner, Alan R.; Mitchell, Braxton D.; Hong, L. Elliot // Nicotine & Tobacco Research;Jul2014, Vol. 16 Issue 7, p923 

    Introduction: Tobacco use is a complex behavior. The Old Order Amish community offers unique advantages for the study of tobacco use because of homogenous ancestral background, sociocultural similarity, sex-specific social norms regarding tobacco use, and large family size. Tobacco use in the...

  • Nicotinic acetylcholine receptor subunit variants are associated with blood pressure; findings in the Old Order Amish and replication in the Framingham Heart Study. McArdle, Patrick F.; Rutherford, Sue; Mitchell, Braxton D.; Damcott, Coleen M.; Ying Wang; Ramachandran, Vasan; Ott, Sandy; Yen-Pei C. Chang; Levy, Daniel; Steinle, Nanette // BMC Medical Genetics;2008, Vol. 9, Special section p1 

    Background: Systemic blood pressure, influenced by both genetic and environmental factors, is regulated via sympathetic nerve activity. We assessed the role of genetic variation in three subunits of the neuromuscular nicotinic acetylcholine receptor positioned on chromosome 2q, a region showing...

  • A computational model for sex-specific genetic architecture of complex traits in humans: Implications for mapping pain sensitivity. Chenguang Wang; Yun Cheng; Tian Liu; Qin Li; Fillingim, Roger B.; Wallace, Margaret R.; Staud, Roland; Kaplan, Lee; Rongling Wu // Molecular Pain;2008, Vol. 4 Issue 1, Special section p1 

    Understanding differences in the genetic architecture of complex traits between the two sexes has significant implications for evolutionary studies and clinical diagnosis. However, our knowledge about sex-specific genetic architecture is limited largely because of a lack of analytical models...

  • Detection of identity by descent using next-generation whole genome sequencing data.  // BMC Bioinformatics;2012, Vol. 13 Issue 1, p121 

    The article presents a study focusing on Identity by descent (IBD). It states that IBD has played an important role in the discovery of genetic loci underlying human diseases. It further discusses the DNA sequencing which enables the comprehensive analysis of genomes. It also mentions that IBD...

  • Relationship between Vascular Calcification and Bone Mineral Density in the Old-Order Amish. Shen, H.; Bielak, L. F.; Streeten, E. A.; Ryan, K. A.; Rumberger, J. A.; Sheedy II, P. F.; Shuldiner, A. R.; Peyser, P. A.; Mitchell, B. D. // Calcified Tissue International;Apr2007, Vol. 80 Issue 4, p244 

    Vascular calcification and osteoporosis are common age-related processes that are influenced by both genetic and nongenetic factors. Whether common genes underlie these processes is not known. We measured coronary artery calcification (CAC), aortic calcification (AC), and bone mineral density...

  • Pervasive Sex-Linked Effects on Transcription Regulation As Revealed by Expression Quantitative Trait Loci Mapping in Lake Whitefish Species Pairs (Coregonus sp., Salmonidae). Derome, N.; Bougas, B.; Rogers, S. M.; Whiteley, A. R.; Labbe, A.; Laroche, J.; Bernatchez, L. // Genetics;Aug2008, Vol. 179 Issue 4, p1903 

    Mapping of expression quantitative ti-alt loci (eQTL) is a powerful means for elucidating the genetic architecture of gene regulation. Yet, eQTL mapping has not been applied toward investigating the regulation architecture of genes involved in the process of population divergence, ultimately...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics