TITLE

A multi-marker test based on family data in genome-wide association study

PUB. DATE
January 2007
SOURCE
BMC Genetics;2007, Vol. 8, p65
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
43678339

 

Related Articles

  • A pathway analysis applied to Genetic Analysis Workshop 16 genome-wide rheumatoid arthritis data. Ballard, David H.; Aporntewan, Chatchawit; Ji Young Lee; Joon Sang Lee; Zheyang Wu; Hongyu Zhao // BMC Proceedings;2009 Supplement 7, Vol. 3, Special section p1 

    The identification of several hundred genomic regions affecting disease risk has proven the ability of genome-wide association studies have proven their ability to identify genetic contributors to disease. Currently, single-nucleotide polymorphism (SNP) association analysis is the most widely...

  • Penalized-regression-based multimarker genotype analysis of Genetic Analysis Workshop 17 data. Ayers, Kristin L.; Mamasoula, Chrysovalanto; Cordell, Heather J. // BMC Proceedings;2011 Supplement 9, Vol. 5 Issue Suppl 9, p1 

    Testing for association between multiple markers and a phenotype can not only capture untyped causal variants in weak linkage disequilibrium with nearby typed markers but also identify the effect of a combination of markers. We propose a sliding window approach that uses multimarker genotypes as...

  • Genome-wide association filtering using a highly locus-specific transmission/disequilibrium test. Abad-Grau, María M.; Medina-Medina, Nuria; Montes-Soldado, Rosana; Moreno-Ortega, José; Matesanz, Fuencisla // Human Genetics;Sep2010, Vol. 128 Issue 3, p325 

    Multimarker transmission/disequilibrium tests (TDTs) are powerful association and linkage tests used to perform genome-wide filtering in the search for disease susceptibility loci. In contrast to case/control studies, they have a low rate of false positives for population stratification and...

  • Comparison between single-marker analysis using Merlin and multi-marker analysis using LASSO for Framingham simulated data. Yun Ju Sung; Rice, Treva K.; Gang Shi; Gu, C. Charles; Rao, D. C. // BMC Proceedings;2009 Supplement 7, Vol. 3, Special section p1 

    We compared family-based single-marker association analysis using Merlin and multi-marker analysis using LASSO (least absolute shrinkage and selection operator) for the low-density lipoprotein phenotype at the first visit for all 200 replicates of the Genetic Analysis Workshop 16 Framingham...

  • Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia. Wason, James M. S.; Dudbridge, Frank // BMC Genetics;2010, Vol. 11, p80 

    Background: Genome-wide association studies (GWAS) are a widely used study design for detecting genetic causes of complex diseases. Current studies provide good coverage of common causal SNPs, but not rare ones. A popular method to detect rare causal variants is haplotype testing. A disadvantage...

  • Development and evaluation of multi-marker risk scores for clinical prognosis. French, Benjamin; Saha-Chaudhuri, Paramita; Ky, Bonnie; Cappola, Thomas P.; Heagerty, Patrick J. // Statistical Methods in Medical Research;Feb2016, Vol. 25 Issue 1, p255 

    Heart failure research suggests that multiple biomarkers could be combined with relevant clinical information to more accurately quantify individual risk and guide patient-specific treatment strategies. Therefore, statistical methodology is required to determine multi-marker risk scores that...

  • Behind the numbers. TAGER, MARK J. // Smart Business Orange County;Winter2013, Vol. 8 Issue 9, p6 

    The article offers information on the benefits of wellness-screening programs for employees run by organizations in the U.S. These wellness- screening programs test height, weight, blood pressure, blood sugar and cholesterol on site. It mentions a report by the Kaiser Family Foundation on...

  • Sample Reproducibility of Genetic Association Using Different Multimarker TDTs in Genome-Wide Association Studies: Characterization and a New Approach. Abad-Grau, Mara M.; Medina-Medina, Nuria; Rosana Montes-Soldado; Fuencisla Matesanz; Bafna, Vineet // PLoS ONE;Feb2012, Vol. 7 Issue 2, p1 

    Multimarker Transmission/Disequilibrium Tests (TDTs) are very robust association tests to population admixture and structure which may be used to identify susceptibility loci in genome-wide association studies. Multimarker TDTs using several markers may increase power by capturing high-degree...

  • Statistical methods in genetics. Montana, Giovanni // Briefings in Bioinformatics;Sep2006, Vol. 7 Issue 3, p297 

    In recent years, a very large variety of statistical methodologies, at various levels of complexity, have been put forward to analyse genotype data and detect genetic variations that may be responsible for increasing the susceptibility to disease. This review provides a concise account of a...

  • Multi-marker-LD based genetic algorithm for tag SNP selection. Mouawad, Amer; Mansour, Nashat // Interdisciplinary Sciences: Computational Life Sciences;Dec2014, Vol. 6 Issue 4, p303 

    Despite the advances in genotyping technologies which have led to large reduction in genotyping cost, the Tag SNP Selection problem remains an important problem for computational biologists and geneticists. Selecting the smallest subset of tag SNPs that can predict the other SNPs would...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics