TITLE

Variation in the gene coding for the M5 Muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults

PUB. DATE
January 2007
SOURCE
BMC Genetics;2007, Vol. 8, p46
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
43677095

 

Related Articles

  • No Association Between Cholinergic Muscarinic Receptor 2 ( CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples. Lind, Penelope A.; Luciano, Michelle; Horan, Michael A.; Marioni, Riccardo E.; Wright, Margaret J.; Bates, Timothy C.; Rabbitt, Patrick; Harris, Sarah E.; Davidson, Yvonne; Deary, Ian J.; Gibbons, Linda; Pickles, Andrew; Ollier, William; Pendleton, Neil; Price, Jackie F.; Payton, Antony; Martin, Nicholas G. // Behavior Genetics;Sep2009, Vol. 39 Issue 5, p513 

    Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor ( CHRM2). In an attempt to replicate this finding we typed...

  • Signal transduction by M3 muscarinic acetylcholine receptor in prostate cancer. LIQIANG GUO; YUQIANG LIU; ZHIBO DING; WENDONG SUN; MINGZHEN YUAN // Oncology Letters;Jan2016, Vol. 11 Issue 1, p385 

    The present study aimed to investigate the potential mechanisms used during signal transduction by M3 muscarinic acetylcholine receptor (CHRM3) in prostate cancer. The microarray datasets of GSE3325, including 5 clinically localized primary prostate cancers and 4 benign prostate tissues, were...

  • Gene-Centric Analysis of Serum Cotinine Levels in African and European American Populations. Hamidovic, Ajna; Goodloe, Robert J; Bergen, Andrew W; Benowitz, Neal L; Styn, Mindi A; Kasberger, Jay L; Choquet, Helene; Young, Taylor R; Meng, Yan; Palmer, Cameron; Pletcher, Mark; Kertesz, Stefan; Hitsman, Brian; Spring, Bonnie; Jorgenson, Eric // Neuropsychopharmacology;Mar2012, Vol. 37 Issue 4, p968 

    To date, most genetic association studies of tobacco use have been conducted in European American subjects using the phenotype of smoking quantity (cigarettes per day). However, smoking quantity is a very imprecise measure of exposure to tobacco smoke constituents. Analyses of alternate...

  • Genetic and Environmental Contributions to Loneliness in Adults: The Netherlands Twin Register Study. Boomsma, Dorret; Willemsen, Gonneke; Dolan, Conor V.; Hawkley, Louise C.; Cacioppo, John T. // Behavior Genetics;Nov2005, Vol. 35 Issue 6, p745 

    Heritability estimates based on two small studies in children indicate that the genetic contribution to individual differences in loneliness is approximately 50%. Heritability estimates of complex traits such as loneliness may change across the lifespan, however, as the frequency, duration, and...

  • Nicotine is addictive, says advisory panel in US. Roberts, John // BMJ: British Medical Journal (International Edition);8/13/94, Vol. 309 Issue 6952, p429 

    Reports the steps taken in regulating cigarettes by the advisory panel of the Food and Drug Administration in the United States. Information on the addictive capacity of nicotine; Policies on the regulation of nicotine in cigarettes; Variation of nicotine doses from user to user.

  • Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction.  // BMC Genomics;2011 Supplement 2, Vol. 12 Issue Suppl 2, p508 

    Background: Classical genetic studies provide strong evidence for heritable contributions to susceptibility to developing dependence on addictive substances. Candidate gene and genome-wide association studies (GWAS) have sought genes, chromosomal regions and allelic variants likely to contribute...

  • Functional Gene Group Analysis Indicates No Role for Heterotrimeric G Proteins in Cognitive Ability. Hill, W. David; de Leeuw, Christiaan; Davies, Gail; Liewald, David Cherry McLachlan; Payton, Anthony; Craig, Leone C. A.; Whalley, Lawrence J.; Horan, Mike; Ollier, William; Starr, John M.; Pendleton, Neil; Posthuma, Danielle; Bates, Timothy C.; Deary, Ian J. // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    Previous functional gene group analyses implicated common single nucleotide polymorphisms (SNPs) in heterotrimeric G protein coding genes as being associated with differences in human intelligence. Here, we sought to replicate this finding using five independent cohorts of older adults including...

  • Neuronal development genes are key elements mediating the reinforcing effects of methamphetamine, amphetamine, and methylphenidate. dela Peña, Ike; Jeon, Se Jin; Lee, Eunyoung; Ryu, Jong Hoon; Shin, Chan Young; Noh, Minsoo; Cheong, Jae Hoon // Psychopharmacology;Dec2013, Vol. 230 Issue 3, p399 

    Rationale: The molecular mechanisms underlying susceptibility to psychostimulant addiction remain unclear. Searching for commonalities in the effects of addictive drugs on brain gene expression is a prolific approach to determine transcriptional signatures influencing drug abuse. Objective: We...

  • Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. Nielsen, D. A.; Ji, F.; Yuferov, V.; Ho, A.; Chen, A.; Levran, O.; Ott, J.; Kreek, M. J. // Molecular Psychiatry;Apr2008, Vol. 13 Issue 4, p417 

    A genome-wide association study was conducted using microarray technology to identify genes that may be associated with the vulnerability to develop heroin addiction, using DNA from 104 individual former severe heroin addicts (meeting Federal criteria for methadone maintenance) and 101...

  • Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia. Scarr, E.; Cowie, T. F.; Kanellakis, S.; Sundram, S.; Pantelis, C.; Dean, B. // Molecular Psychiatry;Nov2009, Vol. 14 Issue 11, p1017 

    Schizophrenia is widely acknowledged as being a syndrome, consisting of an undefined number of diseases probably with differing pathologies. Although studying a syndrome makes the identification of an underlying pathology more difficult; neuroimaging, neuropsychopharmacological and post-mortem...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics