TITLE

Loss of imprinting at the Dlk1-Gtl2 locus caused by insertional mutagenesis in the Gtl2 5' region

PUB. DATE
January 2006
SOURCE
BMC Genetics;2006, Vol. 7, p44
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
No abstract available.
ACCESSION #
43676021

 

Related Articles

  • Alternative splicing and imprinting control of the Meg3/Gtl2-Dlk1 locus in mouse embryos. Croteau, Sylvie; Charron, Marie-Claude; Latham, Keith E.; Naumova, Anna K. // Mammalian Genome;Apr2003, Vol. 14 Issue 4, p231 

    The distal part of the mouse Chr 12 contains a cluster of reciprocally imprinted genes. Recently we found a grandparental origin-dependent, transmission-ratio distortion (TRD) in this region. The TRD resulted from postimplantation loss of embryos that inherited the distal Chr 12 alleles from the...

  • At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1. Hagan, John P.; O'Neill, Brittany L.; Stewart, Colin L.; Kozlov, Serguei V.; Croce, Carlo M. // PLoS ONE;2009, Vol. 4 Issue 2, p1 

    Background: Genomic imprinting is an exception to Mendelian genetics in that imprinted genes are expressed monoallelically, dependent on parental origin. In mammals, imprinted genes are critical in numerous developmental and physiological processes. Aberrant imprinted gene expression is...

  • Expression at the Imprinted Dlk1-Gtl2 Locus Is Regulated by Proneural Genes in the Developing Telencephalon. Seibt, Julie; Armant, Olivier; Le Digarcher, Anne; Castro, Diogo; Ramesh, Vidya; Journot, Laurent; Guillemot, François; Vanderhaeghen, Pierre; Bouschet, Tristan // PLoS ONE;Nov2012, Vol. 7 Issue 11, Special section p1 

    Imprinting is an epigenetic mechanism that restrains the expression of about 100 genes to one allele depending on its parental origin. Several imprinted genes are implicated in neurodevelopmental brain disorders, such as autism, Angelman, and Prader-Willi syndromes. However, how expression of...

  • Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms'tumour. Astuti, D.; Latif, F.; Wagner, K.; Gentle, D.; Cooper, W. N.; Catchpoole, D.; Grundy, R.; Ferguson-Smith, A. C.; Maher, E. R. // British Journal of Cancer;4/25/2005, Vol. 92 Issue 8, p1574 

    Epigenetic alterations in the 11p15.5 imprinted gene cluster are frequent in human cancers and are associated with disordered imprinting of insulin-like growth factor (IGF)2 and H19. Recently, an imprinted gene cluster at 14q32 has been defined and includes two closely linked but reciprocally...

  • Conservation of genomic imprinting at theXIST,IGF2, andGTL2loci in the bovine. Dindot, Scott; Kent, Kathleen; Evers, Bret; Loskutoff, Naida; Womack, James; Piedrahita, Jorge // Mammalian Genome;Dec2004, Vol. 15 Issue 12, p966 

    Genomic imprinting is theorized to exist in all placental mammals and some marsupials; however, extensive comparative analysis of animals aside from humans and mice remains incomplete. Here we report conservation of genomic imprinting in the bovine at the X chromosome inactivation-specific...

  • Epimutation of the TNDM locus and the Beckwith—Wiedemann syndrome centromeric locus in individuals with transient neonatal diabetes mellitus. Mackay, D. J. G.; Hahnemann, J. M. D.; Boonen, S. E.; Poerksen, S.; Bunyan, D. J.; White, H. E.; Durston, V. J.; Thomas, N. S.; Robinson, D. O.; Shield, J. P. H.; Clayton-Smith, J.; Temple, I. K. // Human Genetics;Mar2006, Vol. 119 Issue 1/2, p179 

    Transient neonatal diabetes mellitus (TNDM) is characterised by intra-uterine growth retardation, while Beckwith–Wiedemann syndrome (BWS) is a clinically heterogeneous overgrowth syndrome. Both TNDM and BWS may be caused by aberrant loss of methylation (LOM) at imprinted loci on...

  • Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12. Shau-Ping Lin; Youngson, Neil; Shuji Takada; Hervé Seitz; Reik, Wolf; Paulsen, Martina; Cavaille, Jerome; Ferguson-Smith, Anne C // Nature Genetics;Sep2003, Vol. 35 Issue 1, p97 

    Genomic imprinting causes parental origin-specific gene expression. Cis-acting regulatory elements that control imprinting are not fully understood but involve regions that become differentially methylated on the two parental chromosomes during male and female gametogenesis. Understanding...

  • Cross-talk between imprinted loci in Prader-Willi syndrome. Murrell, Adele // Nature Genetics;Jun2014, Vol. 46 Issue 6, p528 

    Prader-Willi syndrome (PWS) is caused by loss of paternally expressed genes at an imprinted locus on chromosome 15, including the long noncoding RNA IPW. A new study identifies a critical role for IPW in modulating the expression of maternally expressed genes in trans, which has important...

  • Polar overdominant inheritance of a DLK1 polymorphism is associated with growth and fatness in pigs POLAR OVERDOMINANT INHERITANCE OF DLK1 POLYMORPHISM. Kwan-Suk Kim; Jong-Joo Kim; Dekkers, Jack C.M.; Rothschild, Max F. // Mammalian Genome;Jul2004, Vol. 15 Issue 7, p552 

    The polar overdominance model of inheritance was proposed to explain the non-Mendelian expression of callipyge muscular hypertrophy in sheep. The callipyge locus (CLPG) maps to the distal portion of ovine Chromosome 18 within the DLK1– GTL2 region and corresponds to human Chromosome...

  • Selective Methylation of CpGs at Regulatory Binding Sites Controls NNAT Expression in Wilms Tumors. Hubertus, Jochen; Zitzmann, Ferdinand; Trippel, Franziska; Müller-Höcker, Josef; Stehr, Maximilian; von Schweinitz, Dietrich; Kappler, Roland // PLoS ONE;Jun2013, Vol. 8 Issue 6, p1 

    Aberrant expression of imprinted genes, such as those coding for the insulin-like growth factor 2 (IGF2) and neuronatin (NNAT), is a characteristic of a variety of embryonic neoplasms, including Wilms tumor (WT). In case of IGF2, it is generally accepted that loss of imprinting in a...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics