Genome-wide linkage analysis of inguinal hernia in pigs using affected sib pairs

January 2006
BMC Genetics;2006, Vol. 7, p25
Academic Journal
No abstract available.


Related Articles

  • Molecular characterization and exclusion of porcine GUSB as a candidate gene for congenital hernia inguinalis/scrotalis. Beck, Julia; Bornemann-Kolatzki, Kirsten; Knorr, Christoph; Taeubert, Helge; Brenig, Bertram // BMC Veterinary Research;2006, Vol. 2, p1 

    Background: Inguinal hernias are usually caused by a congenital defect, which occurs as a weakness of the inguinal canal. Porcine β-glucuronidase gene (GUSB) was chosen as functional candidate gene because of its involvement in degradation of hyaluronan within gubernacular tissue during...

  • Genome-wide linkage analysis of blood pressure under locus heterogeneity. Xinqun Yang; Kai Wang; Jian Huang; Vieland, Veronica J. // BMC Genetics;2003 Supplement 1, Vol. 4, pS78 

    We describe a method for mapping quantitative trait loci that allows for locus heterogeneity. A genome-wide linkage analysis of blood pressure was performed using sib-pair data from the Framingham Heart Study. Evidence of linkage was found on four markers (GATA89G08, GATA23D06, GATA14E09, and...

  • How accurately can direct and indirect inguinal hernias be distinguished? Ralphs, D.N.L.; Brain, A.J.L.; Grundy, D.J.; Hobsley, M. // British Medical Journal;4/12/1980, Vol. 280 Issue 6220, p1039 

    Investigates the accuracy of distinguishing direct from indirect inguinal hernias. Diagnosis of the disease by paired surgeons; Prediction of the nature of the hernia; Insignificance of inguinal occlusion test as a method to differentiate the types of hernia.

  • Age of diagnosis-based linkage analysis in type 1 diabetes. Paterson, Andrew D; Petronis, Arturas // European Journal of Human Genetics;Feb2000, Vol. 8 Issue 2, p145 

    Genetic linkage studies of type I diabetes have produced a number of conflicting results, suggesting a high degree of locus heterogeneity in this disease. Approaches which model such heterogeneity will increase the power to fine map susceptibility loci. Here, using data from a genome scan of 356...

  • A genome scan in affected sib-pairs with familial vesicoureteral reflux identifies a locus on chromosome 5. Briggs, Christine E.; Chao-Yu Guo; Schoettler, Cynthia; Rosoklija, Ilina; Silva, Andres; Bauer, Stuart B.; Retik, Alan B.; Kunkel, Louis; Nguyen, Hiep T. // European Journal of Human Genetics;Feb2010, Vol. 18 Issue 2, p245 

    The basis for vesicoureteral reflux (VUR) is considered to be primarily genetic, with a 30–50% incidence of VUR in first-degree relatives of patients. The search for the causative gene or genes has been elusive, likely because of VUR being genetically heterogeneous with complex...

  • Single nucleotide polymorphism-based genome-wide linkage analysis in Japanese atopic dermatitis families. Enomoto, Hisako; Noguchi, Emiko; Iijima, Shigeruko; Takahashi, Takenori; Hayakawa, Kazuhito; Ito, Mikako; Kano, Toshiyuki; Aoki, Takeshi; Suzuki, Yoichi; Koga, Minori; Tamari, Mayumi; Shiohara, Tetsuo; Otsuka, Fujio; Arinami, Tadao // BMC Dermatology;2007, Vol. 7, p5 

    Background: Atopic dermatitis develops as a result of complex interactions between several genetic and environmental factors. To date, 4 genome-wide linkage studies of atopic dermatitis have been performed in Caucasian populations, however, similar studies have not been done in Asian...

  • A Region of Chromosome 20 Is Linked to Leprosy Susceptibility in a South Indian Population. Tosh, Kerrie; Meisner, Sarah; Siddiqui, M. Ruby; Balakrishnan, Karuppiah; Ghei, Satish; Golding, Marina; Sengupta, Utpal; Pitchappan, Ramasamy M.; Hill, Adrian V.S. // Journal of Infectious Diseases;10/15/2002, Vol. 186 Issue 8, p1190 

    A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p 13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs....

  • Genomic regions linked to alcohol consumption in the Framingham Heart Study. Bergen, Andrew W.; Xiaohong Rose Yang; Yan Bai; Beerman, Michael B.; Goldstein, Alisa M.; Goldin, Lynn R. // BMC Genetics;2003 Supplement 1, Vol. 4, pS101 

    Background: Pedigree, demographic, square-root transformed maximum alcohol (SRMAXAPD) and maximum cigarette (MAXCPD) consumption, and genome-wide scan data from the Framingham Heart Study (FHS) were used to investigate genetic factors that may affect alcohol and cigarette consumption in this...

  • Affected Sib-Pair Methods for Detecting Linkage to Dichotomous Traits: Review of the Methodology. Holmans, Peter // Human Biology;Dec98, Vol. 70 Issue 6, p1025 

    Reviews the affected sib-pair methodology used to detect linkage to dichotomous traits. Discussion on the principals underlying affected sib-pair tests for linkage; Investigation of the most effective ways to perform genome scans; Reference to the Menelian laws of inheritance hold and the...

  • The effect of genotyping error in sib-pair genomewide linkage scans depends crucially upon the method of analysis. Walters, Kevin // Journal of Human Genetics;Jul2005, Vol. 50 Issue 7, p329 

    In genomewide linkage scans for complex diseases involving many loci with small genetic effects, it may be the case that no loci reach conventional statistical significance. A complementary method of evaluating linkage results, locus counting, may provide evidence for the existence of a number...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics