TITLE

Disease Associations With Monoclonal Gammopathy of Undetermined Significance: A Population-Based Study of 17,398 Patients

AUTHOR(S)
BIDA, JOHN P.; KYLE, ROBERT A.; THERNEAU, TERRY M.; MELTON III, L. JOSEPH; PLEVAK, MATTHEW F.; LARSON, DIRK R.; DISPENZIERI, ANGELA; KATZMANN, JERRY A.; RAJKUMAR, S. VINCENT
PUB. DATE
August 2009
SOURCE
Mayo Clinic Proceedings;Aug2009, Vol. 84 Issue 8, p685
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To systematically study the association of monoclonal gammopathy of undetermined significance (MGUS) with all diseases in a population-based cohort of 17,398 patients, all of whom were uniformly tested for the presence or absence of MGUS. PATIENTS AND METHODS: Serum samples were obtained from 77% (21,463) of the 28,038 enumerated residents in Olmsted County, Minnesota. Informed consent was obtained from patients to study 17,398 samples. Among 17,398 samples tested, 605 cases of MGUS and 16,793 negative controls were identified. The computerized Mayo Medical index was used to obtain information on all diagnoses entered between January 1, 1975, and May 31, 2006, for a total of 422,663 person-years of observations. To identify and confirm previously reported associations, these diagnostic codes were analyzed using stratified Poisson regression, adjusting for age, sex, and total person-years of observation. RESULTS: We confirmed a significant association In 14 (19%) of 75 previously reported disease associations with MGUS, Including vertebral and hip fractures and osteoporosis. Systematic analysis of all 16,062 diagnostic disease codes found additional previously unreported associations, including mycobacterium infection and superficial thrombophlebitis. CONCLUSION: These results have major implications both for confirmed associations and for 61 diseases in which the association with MGUS is likely coincidental.
ACCESSION #
43637592

 

Related Articles

  • Two Populations Are Better Than One. Buchhalter, Jeffrey // Epilepsy Currents;Mar/Apr2012, Vol. 12 Issue 2, p55 

    No abstract available.

  • Fibrinogen plasma concentration before delivery is not associated with postpartum haemorrhage: a prospective observational study. Karlsson, O.; Jeppsson, A.; Thornemo, M.; Lafrenz, H.; Rådström, M.; Hellgren, M. // BJA: The British Journal of Anaesthesia;Jul2015, Vol. 115 Issue 1, p99 

    Background: Lowplasma fibrinogen concentration has been linked to postpartum haemorrhage. The primary aim of this study was to assess whether fibrinogen concentration at admission before labour is associated with severe postpartum haemorrhage. Secondary aims were to describe fibrinogen...

  • Association between intraoperative electroencephalographic suppression and postoperative mortality‡. Willingham, M.; Ben Abdallah, A.; Gradwohl, S.; Helsten, D.; Lin, N.; Villafranca, A.; Jacobsohn, E.; Avidan, M.; Kaiser, H. // BJA: The British Journal of Anaesthesia;Dec2014, Vol. 113 Issue 6, p1001 

    Background Low bispectral index values frequently reflect EEG suppression and have been associated with postoperative mortality. This study investigated whether intraoperative EEG suppression was an independent predictor of 90 day postoperative mortality and explored risk factors for EEG...

  • Patient Non-adherence and Cancellations Are Higher for Screening Colonoscopy Compared with Surveillance Colonoscopy. Greenspan, Michael; Chehl, Navdeep; Shawron, Krista; Barnes, Lisa; Li, Hong; Avery, Elizabeth; Sims, Shannon; Losurdo, John; Mobarhan, Sohrab; Melson, Joshua // Digestive Diseases & Sciences;Oct2015, Vol. 60 Issue 10, p2930 

    Background: A significant proportion of the eligible population is non-adherent to colonoscopy for colorectal cancer (CRC) screening.Aims: To define the demographic and clinical variables associated with non-adherence and multiple cancellations to scheduled colonoscopy...

  • Serum phosphorus predicts incident chronic kidney disease and end-stage renal disease. O’Seaghdha, Conall M.; Hwang, Shih-Jen; Muntner, Paul; Melamed, Michal L.; Fox, Caroline S. // Nephrology Dialysis Transplantation;Sep2011, Vol. 26 Issue 9, p2885 

    Background. Elevations in serum phosphorus are associated with renal decline in animal models and progression of established chronic kidney disease (CKD) in human observational studies. We examined whether serum phosphorus levels increase the risk of incident CKD or end-stage renal disease...

  • Patterns in blood pressure medication use in US incident dialysis patients over the first 6 months. St. Peter, Wendy L.; Sozio, Stephen M.; Shafi, Tariq; Ephraim, Patti L.; Luly, Jason; McDermott, Aidan; Bandeen-Roche, Karen; Meyer, Klemens B.; Crews, Deidra C.; Scialla, Julia J.; Miskulin, Dana C.; Tangri, Navdeep; Jaar, Bernard G.; Michels, Wieneke M.; Wu, Albert W.; Boulware, L Ebony // BMC Nephrology;2013, Vol. 14 Issue 1, p1 

    Background Several observational studies have evaluated the effect of a single exposure window with blood pressure (BP) medications on outcomes in incident dialysis patients, but whether BP medication prescription patterns remain stable or a single exposure window design is adequate to evaluate...

  • Geographic Variations in Retention in Care among HIV-Infected Adults in the United States. Rebeiro, Peter F.; Gange, Stephen J.; Horberg, Michael A.; Abraham, Alison G.; Napravnik, Sonia; Samji, Hasina; Yehia, Baligh R.; Althoff, Keri N.; Moore, Richard D.; Kitahata, Mari M.; Sterling, Timothy R.; Curriero, Frank C.; null, null // PLoS ONE;1/11/2016, Vol. 11 Issue 1, p1 

    Objective: To understand geographic variations in clinical retention, a central component of the HIV care continuum and key to improving individual- and population-level HIV outcomes. Design: We evaluated retention by US region in a retrospective observational study. Methods: Adults receiving...

  • Minicraniotomy for Standard Temporal Lobectomy: A Minimally Invasive Surgical Approach. Al-Otaibi, Faisal; Albloushi, Monirah; Baeesa, Saleh // ISRN Otolaryngology;2014, p1 

    Introduction. The common surgical approach for standard temporal lobectomy is a question-mark skin incision and a fron- totemporal craniotomy. Herein, we describe minicraniotomy approach through a linear skin incision for standard temporal lobectomy. Methods. A retrospective observational cohort...

  • Large-scale, prospective, observational studies in patients with psoriasis and psoriatic arthritis: A systematic and critical review. Langham, Sue; Langham, Julia; Goertz, Hans-Peter; Ratcliffe, Mark // BMC Medical Research Methodology;2011, Vol. 11 Issue 1, p32 

    Background: Observational studies, if conducted appropriately, play an important role in the decision-making process providing invaluable information on effectiveness, patient-reported outcomes and costs in a real-world environment. We conducted a systematic review of large-scale, prospective,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics