Immobilization of lactobionic acid on the surface of cadmium sulfide nanoparticles and their interaction with hepatocytes

Selim, K. M. Kamruzzaman; Xing, Zhi-Cai; Guo, Haiqing; Kang, Inn-Kyu
September 2009
Journal of Materials Science: Materials in Medicine;Sep2009, Vol. 20 Issue 9, p1945
Academic Journal
In the current study, β-galactose-carrying lactobionic acid (LA) was conjugated on the surface of mercaptoacetic acid-coated cadmium sulfide nanoparticles (CSNPs) to ensure specific recognition of liver cells (hepatocytes) and to enhance biocompatibility. Maltotrionic acid-coated CSNPs (MCSNPs) were also prepared for use as a control. The results showed that LA-immobilized CSNPs (LCSNPs) were selectively and rapidly internalized into hepatocytes and emitted more intense fluorescence images as well as demonstrated increased biocompatible behavior in vitro than those of CSNPs and MCSNPs. Furthermore, the uptake amount of LCSNPs into hepatocytes was higher than that of CSNPs and MCSNPs. All these results indicate that LCSNPs may find ever-growing applications in biological labels and detection or contrast agents in life science and medical diagnostics.


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