TITLE

Population-based incidence of Type 2 diabetes and its associated risk factors: results from a six-year cohort study in Iran

AUTHOR(S)
Harati, Hadi; Farzad Hadaegh; Saadat, Navid; Azizi, Fereidoun
PUB. DATE
January 2009
SOURCE
BMC Public Health;2009, Vol. 9, p186
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The Middle East is estimated to have the largest increase in prevalence of diabetes by 2030; yet there is lack of published data on the incidence of Type 2 diabetes in this region. This study aimed to estimate Type 2 diabetes incidence and its associated risk factors in an Iranian urban population. Methods: Among 3307 non-diabetics ≥ 20 years (mean age 42 ± 13 years, 42% males), glucose tolerance test was performed at baseline in 1999-2001 and at two consecutive phases in 2001-2005 and 2005-2008. Diabetes and glucose tolerance status were defined according to the ADA 1997 criteria. Logistic regression was used to determine the independent variables associated with incident diabetes and their odds ratios (OR). Results: After median follow-up of 6 years, 237 new cases of diabetes were ascertained corresponding to an age and sex standardized cumulative incidence of 6.4% (95%CI: 5.6-7.2) and incidence rate of 10.6 (9.2-12.1) per 1000 person years. Besides classical diabetes risk factors, female sex and low education level significantly increased risk of diabetes in age adjusted models. In full model, the independent predictors were age [OR, 95%CI: 1.2 (1.1-1.3)], family history of diabetes [1.8 (1.3-2.5)], body mass index ≥ 30 kg/m² [2.3 (1.5-3.6)], abdominal obesity [1.9 (1.4-2.6)], high triglyceride [1.4 (1.1-1.9)], Isolated impaired fasting glucose (IFG) [7.4 (3.6-15.0)], Isolated impaired glucose tolerance (IGT) [5.9 (4.2-8.4)] and combined IFG and IGT [42.2 (23.8-74.9)]. Conclusion: More than 1% of the Iranian urban population older than 20 years develops Type 2 diabetes each year. Combination of IFG and IGT was the strongest predictor of incident diabetes among the modifiable risk factors.
ACCESSION #
43568356

 

Related Articles

  • Comparison of the fasting and the 2-h glucose criteria for diabetes in different Asian cohorts. Qiao, Q.; Nakagami, T.; Tuomilehto, J.; Borch-Johnsen, K.; Balkau, B.; Iwamoto, Y.; Tajima, N. // Diabetologia;Dec2000, Vol. 43 Issue 12, p1470 

    Aims/hypothesis. The American Diabetes Association recommended that only a single fasting plasma glucose of greater than or equal to 7.0 mmol/l should be used for diagnosing diabetes in epidemiological studies and did not recommend using a 2-h oral glucose tolerance test. We evaluated the effect...

  • Salivary Glucose Concentration and Excretion in Normal and Diabetic Subjects. Jurysta, Cedric; Bulur, Nurdan; Oguzhan, Berrin; Satman, Ilhan; Yilmaz, Temel M.; Malaisse, Willy J.; Sener, Abdullah // Journal of Biomedicine & Biotechnology;2009 Regular Issue, p1 

    The present report aims mainly at a reevaluation of salivary glucose concentration and excretion in unstimulated and mechanically stimulated saliva in both normal and diabetic subjects. In normal subjects, a decrease in saliva glucose concentration, an increase in salivary flow, but an unchanged...

  • Diagnosing Diabetes.  // Pediatrics for Parents;2005, Vol. 22 Issue 4, p7 

    The article discusses the significance of conducting both the fasting plasma glucose (FPG) and oral glucose tolerance tests to any child suspected of having diabetes or impaired glucose tolerance. The FPG test may be fine, but when given as the only test to diagnose diabetes, it misses children...

  • Independent Nurse: Journals Watch - Level of childhood obesity does not predict co-morbidities.  // GP: General Practitioner;2/3/2006, p73 

    The article reports that testing done on children attending an obesity clinic found 10 percent had impaired glucose tolerance, not identified by fasting glucose alone.

  • Body and Liver Fat Mass Rather Than Muscle Mitochondrial Function Determine Glucose Metabolism in Women With a History of Gestational Diabetes Mellitus. PRIKOSZOVICH, THOMAS; WINZER, CHRISTINE; SCHMID, ALBRECHT INGO; SZENDROEDI, JULIA; CHMELIK, MAREK; PACINI, GIOVANNI; KRŠŠÁK, MARTIN; MOSER, EWALD; FUNAHASHI, TOHRU; WALDHÄUSL, WERNER; KAUTZKY-WILLER, ALEXANDRA; RODEN, MICHAEL // Diabetes Care;Feb2011, Vol. 34 Issue 2, p430 

    OBJECTIVE--Ectopic lipid storage in muscle (intramyocellular lipids [IMCL]) and liver (hepatocellular lipids [HCL]) coexists with impaired myocellular flux through ATP synthase (fATPase) in certain cohorts with increased risk of type 2 diabetes. Because women with a history of gestational...

  • Dimensional analysis of MINMOD leads to definition of the disposition index of glucose regulation and improved simulation algorithm. Nittala, Aparna; Ghosh, Soumitra; Stefanovski, Darko; Bergman, Richard; Wang, Xujing // BioMedical Engineering OnLine;2006, Vol. 5, p44 

    Background: Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT) together with its mathematical model, the minimal model (MINMOD), have become important clinical tools to evaluate the metabolic control of glucose in humans. Dimensional analysis of the model is up to now not available....

  • Diabetes in British Nursing and Residential Homes. Aspray, Terence J.; Nesbit, Karen; Cassidy, Timothy P.; Farrow, Emma; Hawthorne, Gillian // Diabetes Care;Mar2006, Vol. 29 Issue 3, p707 

    Presents a study which estimated the prevalence of diabetes and impaired fasting glucose in a range of care-home type patients. Research design and methods; Comparison of screening among residential care and home care patients; Limitation of the study; Guidelines issued by the American Diabetes...

  • Using Metabolic Syndrome Traits for Efficient Detection of Impaired Glucose Tolerance. Meigs, James B.; Williams, Ken; Sullivan, Lisa M.; Hunt, Kelly J.; Haffner, Steven M.; Stern, Michael P.; Villalpando, Clicerio González; Perhanidis, Jessica S.; Nathan, David M.; D'Agostino, Jr, Ralph B.; D'Agostino, Sr, Ralph B.; Wilson, Peter W.F. // Diabetes Care;Jun2004, Vol. 27 Issue 6, p1417 

    Efficient detection of impaired glucose tolerance (IGT) is needed to implement type 2 diabetes prevention interventions. Among FOS, SAHS, and MCDS subjects, 24–43% had MetS and 15–23% had IGT (including 2–5% with 2hPG ≥ 11.1 mmo1/1). Among those with MetS, OR for IGT...

  • Autonomic responses to physiological stressors in women with type 2 diabetes. Franklin, Ruth; Baynard, Tracy; Weinstock, Ruth; Goulopoulou, Styliani; Carhart, Robert; Ploutz-Snyder, Robert; Figueroa, Arturo; Fernhall, Bo; Kanaley, Jill // Clinical Autonomic Research;Apr2008, Vol. 18 Issue 2, p66 

    To compare autonomic function, measured during handgrip (HG) and cold pressor (CP), between obese with and without type 2 diabetes and non-obese women in fasting and post-glucose load states. Twelve obese women with type 2 diabetes (50 � 1 years), 15 obese women without type 2 diabetes (48...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics