Single ricin detection by atomic force microscopy chemomechanical mapping

Guojun Chen; Jianfeng Zhou; Bosoon Park; Bingqian Xu
July 2009
Applied Physics Letters;7/27/2009, Vol. 95 Issue 4, p043103
Academic Journal
The authors report on a study of detecting ricin molecules immobilized on chemically modified Au (111) surface by chemomechanically mapping the molecular interactions with a chemically modified atomic force microscopy (AFM) tip. AFM images resolved the different fold-up conformations of single ricin molecule as well as their intramolecule structure of A- and B-chains. AFM force spectroscopy study of the interaction indicates that the unbinding force has a linear relation with the logarithmic force loading rate, which agrees well with calculations using one-barrier bond dissociation model.


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