Multiplexed highly sensitive detections of cancer biomarkers in thermal space using encapsulated phase change nanoparticles

Liyuan Ma; Yan Hong; Zeyu Ma; Kaittanis, Charalambos; Perez, J. Manuel; Ming Su
July 2009
Applied Physics Letters;7/27/2009, Vol. 95 Issue 4, p043701
Academic Journal
We describe a multiplexed highly sensitive method to detect cancer biomarkers using silica encapsulated phase change nanoparticles as thermal barcodes. During phase changes, nanoparticles absorb heat energy without much temperature rise and show sharp melting peaks (0.6 °C). A series of phase change nanoparticles of metals or alloys can be synthesized in such a way that they melt between 100 and 700 °C, thus the multiplicity could reach 1000. The method has high sensitivity (8 nM) that can be enhanced using materials with large latent heat, nanoparticles with large diameter, or reducing the grafting density of biomolecules on nanoparticles.


Related Articles

  • In Vivo Toxicity of Intravenously Administered Silica and Silicon Nanoparticles. Ivanov, Sergey; Zhuravsky, Sergey; Yukina, Galina; Tomson, Vladimir; Korolev, Dmitry; Galagudza, Michael // Materials (1996-1944);Oct2012, Vol. 5 Issue 10, p1873 

    Both silicon and silica nanoparticles (SiNPs and SiO2NPs, respectively) are currently considered to be promising carriers for targeted drug delivery. However, the available data on their in vivo toxicity are limited. The present study was aimed at investigation of SiNP and SiO2NP (mean diameter...

  • Somatostatin Analogs, How Biomarkers in the Diagnostic and Treatment for Cancer and Others Damages. Molina Trinidad, Eva María; Salas Casas, Andrés // International Journal of Pharmaceutical Sciences Review & Resear;Jul/Aug2014, Vol. 27 Issue 1, p31 

    Biomolecules targets with radioactive nuclides and metallic nanoparticles currently are very use in practices nuclear medicine and general medicine for diagnostic and therapeutic diseases. The investigations new drugs to need go in the direction to obtain personality doses with minimum amount of...

  • Comparison of Eu(NO3)3 and Eu(acac)3 precursors for doping luminescent silica nanoparticles. Enrichi, F.; Riccò, R.; Scopece, P.; Parma, A.; Mazaheri, A. R.; Riello, P.; Benedetti, A. // Journal of Nanoparticle Research;Jun2010, Vol. 12 Issue 5, p1925 

    In this study, we report the comparison between Eu3+-doped silica nanoparticles synthesized by Stöber method using Eu(NO3)3 or Eu(acac)3 as precursors. The impact of different europium species on the properties of the final silica nanospheres is investigated in details in terms of size,...

  • Lung Cancer Signature Biomarkers: tissue specific semantic similarity based clustering of Digital Differential Display (DDD) data. Srivastava, Mousami; Khurana, Pankaj; Sugadev, Ragumani // BMC Research Notes;2012, Vol. 5 Issue 1, p617 

    Background: The tissue-specific Unigene Sets derived from more than one million expressed sequence tags (ESTs) in the NCBI, GenBank database offers a platform for identifying significantly and differentially expressed tissue-specific genes by in-silico methods. Digital differential display (DDD)...

  • Coloring of silica glass with silver nanoparticles. Ageev, L.; Miloslavskiĭ, V.; Makovetskiĭ, E. // Optics & Spectroscopy;Mar2007, Vol. 102 Issue 3, p442 

    The possibility of doping of surface layers of optical fused silica with silver nanogranules upon heating of a thin Ag film on the silica surface by a CO2 laser beam ( P ≈ 30 W, λ = 10.6 μm) is established. The effect of exposure time on the doped layer structure has been...

  • Luminescent silica nanoparticles modified with a functional pyrylocyanine dye. Orlova, N. A.; Kargapolova, I. Yu.; Shelkovnikov, V. V.; Plekhanov, A. I. // High Energy Chemistry;Dec2009, Vol. 43 Issue 7, p602 

    A method was developed for the chemical modification of silica nanoparticles with a pyrylium dye under the sol-gel synthesis conditions. The films of silica particles modified with a pyrylium dye gave greenish blue luminescence with a maximum at 490 nm upon treatment with a solution of...

  • Particle size, uniformity, and mesostructure control of magnetic core/mesoporous silica shell nanocomposite spheres. Wenru Zhao; Jianlin Shi; Hangrong Chen; Lingxia Zhang // Journal of Materials Research;Dec2006, Vol. 21 Issue 12, p16 

    Well-structured and monodisperse nanocomposite spheres with a magnetic core/mesoporous silica shell structure (MCMS) were obtained. The effects on the structure and morphology of the MCMS spheres were investigated under various synthesis conditions, including reaction time, quantity of silicate...

  • Lead uptake by new silica-carbon nanoparticles. Hammud, Hassan Hasan; Chahine, Mayssam Mostafa; Hamaoui, Bassem El; Younes Hanifehpour // European Journal of Chemistry;Dec2013, Vol. 4 Issue 4, p425 

    Silica-carbon nanoparticles (SCNP) were prepared from sonication of silica and anthracene. The size of homogenous nanoparticle is around 5-20nm confirmed by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). SEM analysis indicated surface porosity. SCNP were used to...

  • Direct observation of blocked nanoscale surface evaporation on SiO2 nanodroplets. Wan, Neng; Xu, Jun; Sun, Li-Tao; Martini, Matteo; Huang, Qing-An; Hu, Xiao-Hui; Xu, Tao; Bi, Heng-Chang; Sun, Jun // Applied Physics Letters;10/29/2012, Vol. 101 Issue 18, p183114 

    Nano-scale surface evaporation of SiO2 nanodroplets from a volcano-shaped tip (tip diameter d ∼ 20 nm to 70 nm) was observed directly using an in situ transmission electron microscopy method. Au nanoparticles, those precipitated in the SiO2 matrix after an Au catalyzed growth, diffused and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics