TITLE

Multiplexed highly sensitive detections of cancer biomarkers in thermal space using encapsulated phase change nanoparticles

AUTHOR(S)
Liyuan Ma; Yan Hong; Zeyu Ma; Kaittanis, Charalambos; Perez, J. Manuel; Ming Su
PUB. DATE
July 2009
SOURCE
Applied Physics Letters;7/27/2009, Vol. 95 Issue 4, p043701
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We describe a multiplexed highly sensitive method to detect cancer biomarkers using silica encapsulated phase change nanoparticles as thermal barcodes. During phase changes, nanoparticles absorb heat energy without much temperature rise and show sharp melting peaks (0.6 °C). A series of phase change nanoparticles of metals or alloys can be synthesized in such a way that they melt between 100 and 700 °C, thus the multiplicity could reach 1000. The method has high sensitivity (8 nM) that can be enhanced using materials with large latent heat, nanoparticles with large diameter, or reducing the grafting density of biomolecules on nanoparticles.
ACCESSION #
43494239

 

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