Polyethylcyanoacrylate nanoparticle transport through the stratum corneum

Díaz-Torres, Roberto; Jiménez Sandoval, Sergio J.; Ibañez-Orozco, Oscar; Rodríguez-Romo, Suemi
July 2009
Applied Physics Letters;7/27/2009, Vol. 95 Issue 4, p043702
Academic Journal
The traceability of polyethylcyanoacrylate nanoparticles transported through human skin is studied in this paper. Photoluminescence is used to find the precise diffusion path of polyethylcyanoacrylate nanoparticles through the skin stratum corneum (SC). Reproducible data were obtained, and the nanoparticles’ distribution in each layer of the SC is presented. We contribute to the basic knowledge of these phenomena as a stationary stochastic process using a one-dimensional linear chain model with the left end open and the right end closed. Possible applications are in the field of pharmaceutical technology, especially concerning drug transport through the skin by nanoparticle carriers.


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