TITLE

New technology enables high precision multislit collimators for microbeam radiation therapy

AUTHOR(S)
Bräuer-Krisch, E.; Requardt, H.; Brochard, T.; Berruyer, G.; Renier, M.; Laissue, J. A.; Bravin, A.
PUB. DATE
July 2009
SOURCE
Review of Scientific Instruments;Jul2009, Vol. 80 Issue 7, p074301
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
During the past decade microbeam radiation therapy has evolved from preclinical studies to a stage in which clinical trials can be planned, using spatially fractionated, highly collimated and high intensity beams like those generated at the x-ray ID17 beamline of the European Synchrotron Radiation Facility. The production of such microbeams typically between 25 and 100 μm full width at half maximum (FWHM) values and 100–400 μm center-to-center (c-t-c) spacings requires a multislit collimator either with fixed or adjustable microbeam width. The mechanical regularity of such devices is the most important property required to produce an array of identical microbeams. That ensures treatment reproducibility and reliable use of Monte Carlo-based treatment planning systems. New high precision wire cutting techniques allow the fabrication of these collimators made of tungsten carbide. We present a variable slit width collimator as well as a single slit device with a fixed setting of 50 μm FWHM and 400 μm c-t-c, both able to cover irradiation fields of 50 mm width, deemed to meet clinical requirements. Important improvements have reduced the standard deviation of 5.5 μm to less than 1 μm for a nominal FWHM value of 25 μm. The specifications of both devices, the methods used to measure these characteristics, and the results are presented.
ACCESSION #
43494126

 

Related Articles

  • MCNP SIMULATION OF A THERATRON 780 RADIOTHERAPY UNIT. Miró, R.; Soler, J.; Gallardo, S.; Campayo, J. M.; Díez, S.; Verdú, G. // Radiation Protection Dosimetry;2005, Vol. 116 Issue 1-4, p65 

    A Theratron 780 (MDS Nordion) 60Co radiotherapy unit has been simulated with the Monte Carlo code MCNP. The unit has been realistically modelled: the cylindrical source capsule and its housing, the rectangular collimator system, both the primary and secondary jaws and the air gaps between the...

  • Dosimetric Studies of a mMLC for Intensity Modulated Radiation Surgery for Irregular Lesions. Garcia-Garduno, Olivia Amanda; Rodriguez-Villafuerte, Mercedes; Larraga-Gutierrez, Jose Manuel; Celis-Lopez, Miguel Angel // AIP Conference Proceedings;2003, Vol. 682 Issue 1, p167 

    In this work we present the commissioning of a micro Multileaf Collimator (mMLC) of the Novalisâ„¢ Intensity Modulated Radiation Surgery (IMRS) system. This system can deliver conventional stereotactic radiosurgery, conformal arcs and beams, and IMRS. The last modalities are performed using...

  • Respective roles of scatter, attenuation, depth-dependent collimator response and finite spatial resolution in cardiac single-photon emission tomography quantitation: a Monte Carlo study. El Fakhri, Georges N.; Buvat, Irène; Pélégrini, Mélanie; Benali, Habib; Almeida, Pedro; Bendriem, Bernard; Todd-Pokropek, Andrew; Di Paola, Robert // European Journal of Nuclear Medicine;1999, Vol. 26 Issue 5, p437 

    Abstract. The purpose of this study was to investigate the relative influence of scatter, attenuation, depth-dependent collimator response and finite spatial resolution upon the image characteristics in cardiac single-photon emission tomography (SPET). An acquisition of an anthropomorphic...

  • Dosimetric evaluation of a new collimator insert system for stereotactic radiotherapy. T Paschalis; P Sandilos; E Tatsis; P Karaiskos; C Antypas; C Chatzigiannis; K Dardoufas; E Georgiou; L Vlachos // British Journal of Radiology;Jun2007, Vol. 80 Issue 954, p446 

    The prototype of a stereotactic collimator set developed in our department is evaluated for clinical use. This set consists of three cylindrical blocks mounted on a tray which slides in the wedge insert of a Siemens Primus accelerator. Each block has a collimating hole along its long axis to...

  • Progress in the conceptual development of the ITER vertical neutron collimator. Tsutskikh, A.; Prosvirin, D.; Krasil’nikov, A.; Walker, C. // Instruments & Experimental Techniques;Mar2006, Vol. 49 Issue 2, p174 

    Monte-Carlo calculations of the fluxes of forward and scattered neutrons at points of arrangement of the detectors for the analyzed design of the ITER multichannel vertical neutron collimator have been performed with the MCNP model. A concept of a vertical neutron collimator positioned in the...

  • The use of multichannel collimation in small-angle neutron scattering: a computer-simulation study. Falcão, A.N.; Margaça, F.M.A.; Carvalho, F.G. // Applied Physics A: Materials Science & Processing;Dec2002 Supplement, Vol. 74 Issue 6, ps1462 

    A Monte Carlo computer simulation was performed to evaluate the use of converging multichannel collimation in a small-angle neutron-scattering arrangement, giving guidelines for the construction of a first prototype. The neutron-absorbing efficiency as well as the divergence of the incoming beam...

  • Angular distributions of electrons transmitted ballistically through tapered constrictions. Hornsey, R. I. // Journal of Applied Physics;6/15/1996, Vol. 79 Issue 12, p9172 

    Presents a study on the angular distribution of electrons injected ballistically through constrictions with a variety of simple geometries and specularity coefficients using a Monte Carlo approach. Examples of novel physics provided by the electronic devices which exploit the ballistic...

  • Simulation of bent crystal spectrometers. Kyrala, George A. // Review of Scientific Instruments;May85, Vol. 56 Issue 5, p815 

    In crystal spectrometers one traditionally labels each position in the dispersion/recording plane by a single wavelength value. A simple examination of the crystal spectrometers shows that different areas of the crystal contribute different wavelengths at the same position in the recording...

  • Design of a multislit, variable width collimator for microplanar beam radiotherapy. Slatkin, D.N.; Dilmanian, F.A.; Nawrocky, M.M.; Spanne, P.; Gebbers, J.-O.; Archer, D.W.; Laissue, J.A. // Review of Scientific Instruments;Feb1995, Vol. 66 Issue 2, p1459 

    Describes the design and use of a multislit, variable width collimator for microplanar beam radiation therapy of the intracerebral 9L giosarcoma in rats. Ability of microbeam radiation therapy to palliate or ablate large right frontocerebral brain tumors in rats; Skin-entrance absorbed dose...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics