TITLE

Chilblains and Raynaud Phenomenon are Usually not a Sign of Hereditary Protein C and S Deficiencies: Clinical Reports

AUTHOR(S)
Benchikhi, H.; Roujeau, J. C.; Levent, M.; Gouault-Heilmann, M.; Revuz, J.; Cosnes, A.
PUB. DATE
September 1998
SOURCE
Acta Dermato-Venereologica;09/01/98, Vol. 78 Issue 5, p351
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Hereditary protein C and S deficiencies are risk factors for thrombosis. They are associated with purpura fulminans and coumarin-induced skin necrosis. Recently, necrotic livedo of the extremities, severe chilblains and severe frostbite have been observed in protein C or S deficient patients. Our study was designed to evaluate the prevalence of cold-induced acral manifestations in patients with protein C or S deficiency. One-hundred-and-six patients with protein C or S deficiency and controls matched for sex and age were studied by questionnaire. Data included any history of acral manifestation possibly related to cold exposure, i.e. chilblains, Raynaud phenomenon, acrocyanosis and possible associated factors. Assessment of the diagnosis by a dermatologist was recorded. No difference was found in the prevalence of acral manifestations between patients and controls. This study suggests that protein C and S deficiencies are not risk factors for cold-induced acral manifestations.
ACCESSION #
4347950

 

Related Articles

  • Anna: too much, too young. Fullbrook, John // BMJ: British Medical Journal (International Edition);09/12/98, Vol. 317 Issue 7160, p756 

    Presents information on an experience of a family with their infant, Anna, who suffered a protein C deficiency, which resulted in numerous ailments including blindness and physical disabilities. Details on the numerous visits Anna encountered at various specialists including a haematologist;...

  • Hydroxychloroquine and Surfactant Protein C Deficiency. Rosen, Dennis M.; Waltz, David A. // New England Journal of Medicine;1/13/2005, Vol. 352 Issue 2, p207 

    A letter to the editor discussing the use of hydroxychloroquine in patients with surfactant protein C deficiency is presented.

  • Role of genetic prothrombotic risk factors in childhood caval vein thrombosis. Münchow, N.; Kosch, A.; Schobess, R.; Junker, R.; Auberger, K.; Nowak-Göttl, U. // European Journal of Pediatrics;1999, Vol. 158 Issue 15, pS109 

    Abstract Childhood caval vein thrombosis has a high incidence especially in the first year of life. Besides deficiencies of protein C, protein S, antithrombin and plasminogen, the factor (F) V G1691A mutation, the prothrombin (PT) G20210A variant, the methylenetetrahydro-folate reductase (MTHFR)...

  • Liječenje duboke venske tromboze u Dnevnoj bolnici Kliničkog odjela za vaskularne bolesti SveučiliÅ¡nog kliničkog centra Ljubljana. Janša-Trontelj, Katja // Cardiologia Croatica;Sep/Oct2014, Vol. 9 Issue 9/10, p489 

    Cardiovascular diseases are one of the leading causes of morbidity and mortality in the world and in Slovenia. Deep venous thrombosis is an epidemiological, health and economic problem. The disease shows a rising trend despite the insights about its prevention. Outpatient treatment is as...

  • Factor V G1691A and prothrombin G20210A in childhood spontaneous venous thrombosis - Evidence of an age-dependent thrombotic onset in carriers of factor V G1691A and prothrombin G20210A mutation. Schobess, R.; Junker, R.; Auberger, K.; Münchow, N.; Burdach, S.; Nowak-Göttl, U. // European Journal of Pediatrics;1999, Vol. 158 Issue 15, pS105 

    Abstract Risk factors for venous thrombosis in adults are the prothrombin (PT) G20210A, the factor (F) V G1691A mutations and hereditary deficiencies of protein C, protein S and antithrombin. However, data are limited on the relevance of these risk factors for thrombosis in children and...

  • Mesenteric venous thrombosis associated with protein C deficiency. Mitani, Masami; Kuwabara, Yoshiyuki; Kawamura, Hiroyuki; Sato, Atsusi; Hattori, Koji; Fujii, Yoshitaka // Journal of Gastroenterology;1999, Vol. 34 Issue 3, p387 

    Abstract: An 83-year-old man had gradually worsening abdominal pain and vomiting. Laparotomy revealed segmental intestinal infarction resulting from thrombosis in the superior mesenteric vein. Necrosed intestine was resected and anastomosis was performed successfully. The patient was...

  • Coumarin Necrosis Associated with Hereditary Protein C Deficiency. McGehee, William G.; Klotz, Thomas A.; Epstein, David J.; Rapaport, Samuel I. // Annals of Internal Medicine;Jul84, Vol. 101 Issue 1, p59 

    Presents a case study on a patient with coumarin penile necrosis whose case was previously reported has hereditary deficiency in protein C. Description of coumarin skin necrosis; Information on the patient; Recommendations.

  • Successful Warfarin Anticoagulation Despite Protein C Deficiency and a History of Warfarin Necrosis. Zauber, N. Peter; Stark, Michael W. // Annals of Internal Medicine;May86, Vol. 104 Issue 5, p659 

    Presents a case study of treating protein C deficiency with warfarin anticoagulation in a 44-year-old man. Medical history of the patient; Diagnosis of the disease; Details of the effectiveness of warfarin anticoagulation treatment.

  • The river of life. Weaver, Daniel C. // Discover;Nov97, Vol. 18 Issue 11, p52 

    Recounts the author's experiences with a patient with a blood clot disorder. Diagnosis; Protein C deficiency; Genetic aspects of the disease.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics