TITLE

Pharmacokinetics and efficacy of teicoplanin against intramammary infections in sheep

AUTHOR(S)
Naccari, C.; Niutta, P. P.; Trombetta, D.; De Domenico, A.; Pizzimenti, F.; Cagnardi, P.; Carli, S.; Naccari, F.
PUB. DATE
July 2009
SOURCE
Veterinary Record: Journal of the British Veterinary Association;7/4/2009, Vol. 165 Issue 1, p19
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The pharmacokinetics of teicoplanin were evaluated in 10 healthy sheep. After intravenous injection it showed monophasic behaviour, with a short mean (sd) elimination half-life (5 (0.24] hours). After intramuscular injection its bioavailability was 100 per cent but it was absorbed slowly; its elimination half-life was satisfactorily slow (9-23 (074] hours). Its efficacy was evaluated in 26 crossbreed sheep with milk positive to strains of Staphylococcus aureus, coagulase-negative staphylococci and Streptococcus agalactlae, and clinical signs of disease. In 19 of them a single intramuscular dose of 6 mg/kg bodyweight resulted in a complete resolution of the clinical signs, and no microorganisms were detected in milk by the fifth day; in the other seven sheep, with more severe intramammary infections, three consecutive daily intramuscular doses of 6 mg/kg bodyweight were necessary. There were no local or systemic side effects and no relapses during 30 days after the treatments in any of the sheep.
ACCESSION #
43457217

 

Related Articles

  • Disposition Kinetics of Enrofloxacin Following Intramuscular Administration in Goats. Hussain, Tariq; Javed, Ijaz; Muhammad, Faqir; Zia-ur-Rahman // Pakistan Veterinary Journal;2014, Vol. 34 Issue 3, p293 

    Enrofloxacin (ENRO) is a second generation fluoroquinolone that was specially developed for clinically use in veterinary practice. Most of the previous studies on the pharmacokinetics of antibiotics have emphasized that the optimal therapeutic dosage of imported drugs should be determined in the...

  • Leuprorelin.  // Reactions Weekly;6/2/2012, Issue 1404, p26 

    The article describes a case of sterile abscess formation at injection sites in a 6.5-year-old-girl while being treated with intramuscular (IM) leuprorelin depot for central precocious puberty.

  • Amikacin.  // Reactions Weekly;6/19/2010, Issue 1306, p8 

    The article describes two case reports of boys aged 3 and 6 years who experienced localized lipoatrophy following intramuscular injection of amikacin, published in the October 2009 issue of the "Indian Journal of Dermatology."

  • Intramuscular prolonged-release paliperidone palmitate: a guide to its use in schizophrenia.  // Drugs & Therapy Perspectives;Nov2011, Vol. 27 Issue 11, p1 

    Intramuscular prolonged-release paliperidone palmitate is indicated for the treatment of schizophrenia. In clinical trials, intramuscular paliperidone palmitate was associated with improvements in schizophrenia-related outcomes relative to placebo. At approved dosage regimens, intramuscular...

  • lidocaine/prilocaine.  // Davis's Drug Guide for Nurses, 10th edition;2007, p718 

    The article presents a nursing guide for lidocaine/prilocaine, topical or local anesthetic drugs. It is indicated for minor painful procedures: insertion of cannulae or needles, intramuscular injections and laser treatments. The mechanism of action and pharmacokinetics are discussed. Information...

  • PENICILLIN. Reed, Stephen // Equus;Oct2011, Issue 409, p26 

    The article discusses the safe and appropriate use of penicillin, an antibiotic against bacterial infections for both humans and animals. A brief history of the penicillin is provided. Its mechanism of action is described. Penicillin may be administered intravenously and by intramuscular...

  • Pharmacokinetics and Bioavailability of Ceftriaxone in Patanwadi Sheep. Tiwari, S.; Patel, U. D.; Bhavsar, S. K.; Thaker, A. M. // VetScan;2010, Vol. 5 Issue 2, p45 

    Pharmacokinetics of ceftriaxone following single dose intravenous and intramuscular administration (10 mg/kg) in six Patanwadi sheep was determined. The plasma concentration-time curves were characteristic of a two and onecompartment open model following intravenous and intramuscular...

  • Disposition of Ceftriaxone in Goats (Capra hircus). Swati, S. Tiwari; Bhavsar, S. K.; Patel, U. D.; Thaker, A. M. // VetScan;2009, Vol. 4 Issue 2, p21 

    Pharmacokinetics of ceftriaxone was determined in goats after single dose intravenous and intramuscular administration at the dose rate of 20 mg/kg body weight. The drug concentrations in plasma samples were measured through High Performance Liquid Chromatography. Following intravenous...

  • What to watch for when you give a cephalosporin. White, Sara J.; Williamson, Karin // RN;Aug79, Vol. 42 Issue 8, p29 

    Provides information on the pharmacokinetics of the semisynthetic antibiotics, cephalosporin. Therapeutic applications of cephalosporin; Interaction with other drugs; Adverse effects of cephalosporin.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics