Pharmacokinetics and efficacy of teicoplanin against intramammary infections in sheep

Naccari, C.; Niutta, P. P.; Trombetta, D.; De Domenico, A.; Pizzimenti, F.; Cagnardi, P.; Carli, S.; Naccari, F.
July 2009
Veterinary Record: Journal of the British Veterinary Association;7/4/2009, Vol. 165 Issue 1, p19
Academic Journal
The pharmacokinetics of teicoplanin were evaluated in 10 healthy sheep. After intravenous injection it showed monophasic behaviour, with a short mean (sd) elimination half-life (5 (0.24] hours). After intramuscular injection its bioavailability was 100 per cent but it was absorbed slowly; its elimination half-life was satisfactorily slow (9-23 (074] hours). Its efficacy was evaluated in 26 crossbreed sheep with milk positive to strains of Staphylococcus aureus, coagulase-negative staphylococci and Streptococcus agalactlae, and clinical signs of disease. In 19 of them a single intramuscular dose of 6 mg/kg bodyweight resulted in a complete resolution of the clinical signs, and no microorganisms were detected in milk by the fifth day; in the other seven sheep, with more severe intramammary infections, three consecutive daily intramuscular doses of 6 mg/kg bodyweight were necessary. There were no local or systemic side effects and no relapses during 30 days after the treatments in any of the sheep.


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