Differential Epidermal Expression of the Invariant Chain in Allergic and Irritant Contact Dermatitis

Emilson, Axel; Lindberg, Magnus; Scheynius, Annika
October 1998
Acta Dermato-Venereologica;10/28/98, Vol. 78 Issue 6, p402
Academic Journal
Allergic contact dermatitis and irritant contact dermatitis have different pathogenic mechanisms. It is therefore plausible that the epidermal expression of HLA-DR and the invariant chain associated with antigen processing and presentation might differ between allergic contact dermatitis and irritant contact dermatitis. We have quantified the volume of epidermal HLA-DR and invariant chain reactivity and the total epidermal volume in allergic contact dermatitis and irritant contact dermatitis using confocal laser scanning microscopy and indirect immunofluorescence on acetone-fixed 25 μm thick vertical skin sections. Eight nickel allergic patients were patch-tested with 5% nickel sulfate and 8 healthy volunteers were patch-tested with 4% sodium lauryl sulfate. Skin biopsy specimens were taken at 0, 6, 24, and 72 h after application of the patch tests. Sodium lauryl sulfate induced a statistically significant increased epidermal volume at 24 h and 72 h compared to 0 h and 6 h (p<0.003 and p<0.001, respectively), whereas an increase in epidermal volume in the allergic contact dermatitis group was not noted until 72 h after patch testing with nickel sulfate compared to 0, 6 h (p<0.001) and 24 h (p<0.004). No significant changes in the epidermal volume of HLA-DR reactivity were found at any time point within or between the two groups, nor was there any significant change in the epidermal volume of invariant chain reactivity in the allergic contact dermatitis group. In the irritant contact dermatitis group, however, the epidermal volume of invariant chain reactivity was significantly reduced from 17±8×10[sup 3] μm[sup 3] at 24 h to 9±3×10[sup 3] μm[sup 3] at 72 h (p<0.04), which was also significantly lower than the 14±4×10[sup 3] μm[sup 3] observed in allergic contact dermatitis at 72 h (p<0.01). Furthermore, the invariant chain expression was significantly lower than the HLA-DR reactivity in the irritant contact dermatitis group at 72 h (p<0.001). The decrease of invariant chain reactivity at 72 h in irritant contact dermatitis might reflect an epitope-induced alteration by sodium lauryl sulfate or a down-regulated biosynthesis of the invariant chain due to variance in local cytokine production between allergic contact dermatitis and irritant contact dermatitis.


Related Articles

  • Etiology and treatment of Seabather's eruption.  // American Family Physician;9/15/1993, Vol. 48 Issue 4, p656 

    Reports on the clinical manifestations, etiology and treatment of the skin disease seabather's eruption as cited in a study by Tomchik and colleagues in the April 7, 1993 edition of `JAMA'. Characteristics of skin lesions; Systemic symptoms; May as peak month; Areas of prevalence; Implication of...

  • A skin reaction.  // Pediatrics for Parents;1996, Vol. 16 Issue 11, p3 

    Provides information on substances that may cause skin reactions called contact dermatitis or allergic dermatitis according to an article published in the November 1, 1996 issue of the `Family Practice News' journal. Nickel in pierced earrings and clothing snaps; Topical antibiotics;...

  • Exploring new concerns in allergic contact dermatitis. Newman, Laura // Dermatology Times;Dec96, Vol. 17 Issue 12, p18 

    Reports on the need for more sensitive and specific tests for allergic contact dermatitis. Fragrance testing; Allergies to natural fragrances; Standard patch tests.

  • The red lady. Bennett, Leslie // Cortlandt Forum;08/25/97, Vol. 10 Issue 8, p42 

    Relates the author's experience with a patient who suffered contact dermatitis from wearing fake suede outfit. Symptoms; Diagnostic tests performed; Medications given to the patient.

  • Cetyl alcohol.  // Reactions Weekly;3/19/2011, Issue 1343, p12 

    The article describes the cases of two women who developed allergic contact dermatitis while using products containing cetyl alcohol.

  • Ketoprofen.  // Reactions Weekly;12/4/2010, Issue 1330, p24 

    The article describes the case of a 58-year-old woman, who developed photoallergic contact dermatitis after using a topical compress containing ketoprofen and hydrogenated rosin glycerol ester.

  • Verteporfin Maintains Contrast Sensitivity.  // Review of Ophthalmology;Jan2003, Vol. 10 Issue 1, p50 

    Reports on the impact of verteporfin therapy on the contact sensitivity of patients suffered from cataract. Comparison between placebo and verteporfin therapy; Prevention of loss of contrast sensitivity; Benefits for patients receiving photodynamic therapy.

  • Patch tests are underused for pinpointing contact dermatitis.  // Modern Medicine;Mar95, Vol. 63 Issue 3, p24 

    Discusses the need for patch testing to identify the cause of allergic contact dermatitis. Caution in testing of patients with severe allergic reactions; Differentiation of contact dermatitis from other disorders; Importance of determining the cause.

  • Contact allergies.  // Pulse;3/3/2009, Vol. 70 Issue 7, p27 

    A quiz concerning the types of allergen that cause contact dermatitis is presented.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics