TITLE

Expression of Trichohyalin in Dermatological Disorders: a Comparative Study with Involucrin and Filaggrin by Immunohistochemical Staining

AUTHOR(S)
Lee, Seung-Chul; Lee, Jee-Bum; Seo, Jae-Jeong; Pio Kim, Young
PUB. DATE
May 1999
SOURCE
Acta Dermato-Venereologica;5/26/99, Vol. 79 Issue 2, p122
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To investigate the function of trichohyalin during terminal differentiation of the skin, immunohistochemical studies were performed on trichohyalin and its related proteins, filaggrin and involucrin, the components of the cornified cell envelope. In skin disorders unrelated to tumours, weak trichohyalin expression was found in a few granular cells or in the horny layer of psoriasis, ichthyosis, keratosis pilaris, porokeratosis, chronic dermatitis and callus. Similar trichohyalin expression was found in epidermal tumours, such as seborrheic keratosis, actinic keratosis, Bowen's disease and well-differentiated squamous cell carcinoma. In follicular tumours, trichohyalin expression was positive in trichoepithelioma, keratotic basal cell epithelioma, proliferating trichilemmal tumour, trichilemmoma, pilomatricoma and keratoacanthoma. From comparative studies with filaggrin and involucrin, trichohyalin expression was co-localized with them in molluscum contagiosum, keratoacanthoma and pilomatricoma. From this study, trichohyalin is revealed to have close functional relationship with other markers of terminal differentiation as a precursor of the cornified cell envelope of the skin.
ACCESSION #
4342660

 

Related Articles

  • Immunohistological analysis of immune cells in blistering skin lesions. Mahmoud R Hussein // Journal of Clinical Pathology;Jan2007, Vol. 60 Issue 1, p62 

    BACKGROUND: Bullous skin lesions are characterised by the presence of intraepidermal or subepidermal bullae. Although inflammatory cell infiltrate is a constant feature in these lesions, their immunophenotypic characterisation is still incomplete. Aim: To determine whether the development of...

  • Immunohistochemical Demonstration of Age-related Deposition of Vitronectin (S-protein of Complement) and Terminal Complement Complex on Dermal Elastic Fibers. Dahlbäck, Karin; Löfberg, Helge; Alumets, Jan; Dahlbäck, Björn // Journal of Investigative Dermatology;May89, Vol. 92 Issue 5, p727 

    Immunoreactivity of vitronectin was investigated in 100 skin specimens from different body regions in 87 individuals of different ages using monoclonal and polyclonal anti-vitro-nectin antibodies in an avidin - biotin - peroxidase complex technique. Vitronectin immunoreactivity was found in...

  • IgG Antibodies from Patients with Bullous Pemphigoid Bind to Fusion Proteins Encoded by BPAg1 cDNA. Miller, Jeanne E.; Rico, M. Joyce; Hall III, Russell P. // Journal of Investigative Dermatology;Dec93, Vol. 101 Issue 6, p779 

    Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized in part by the presence of circulating and tissue-bound IgG antibodies directed against the epidermal basement membrane zone. IgG from over 95% of patients with BP have been shown to immunoprecipitate a 230-kD...

  • NEURAL REACTIVITY DETECTED BY IMMUNOFLUORESCENCE IN A PATIENT WITH A LOCALIZED BLISTERING DISEASE. Abreu Velez, Ana Maria; Howard, Michael S. // Our Dermatology Online / Nasza Dermatologia Online;Jan2013, Vol. 4 Issue 1, p91 

    Introduction: Multiple clinical etiologies exist for rapidly appearing skin blisters are multiple. Case report: A 69-year-old male from a rural area of Georgia, USA, was evaluated for the presence of suddenly appearing, localized erythema and edema on his leg with a skin blister. At...

  • Resolving diagnostic impasses. Guttman, Cheryl // Dermatology Times;Apr2005, Vol. 26 Issue 4, p66 

    This article presents suggestions of dermatologist Clay J. Cockerell to resolve diagnostic impasses, as stated at the Fall and Winter 2004 Dermatology Conference, held in Las Vegas, Neveda. According to Cockerell, immunohistochemical stains can be a valuable aid to the dermatopathologist for...

  • MAST CELLS, MAST/STEM CELL GROWTH FACTOR RECEPTOR (C-KIT/CD117) AND IGE MAY BE INTEGRAL TO THE PATHOGENESIS OF ENDEMIC PEMPHIGUS FOLIACEUS. Abreu Velez, Ana Maria; Roselino, Ana Maria; Howard, Michael S. // Our Dermatology Online / Nasza Dermatologia Online;Nov2013 Supplement, p596 

    Introduction: Pemphigus foliaceus (PF) is endemic in some South American countries, especially in Colombia and Brazil; in Brazil, it is also known as fogo selvagem (FS). We aimed to study the presence of mast cells and the expression of the mast/stem cell growth factor receptor (c-kit/CD117) in...

  • Analytical quantification of the inflammatory cell infiltrate and CD95R expression during treatment of drug-induced toxic epidermal necrolysis. Paquet, Philippe; Jacob, Eric; Damas, Pierre; Pirson, Jean; Piérard, Gérald // Archives of Dermatological Research;Dec2005, Vol. 297 Issue 6, p266 

    The treatment of drug-induced toxic epidermal necrolysis (TEN) remains unsatisfactory. Intravenous immunoglobulins (IVIg) and intravenous cyclosporin A (CsA) have shown some efficacy in short series of patients. We assessed the effects of IVIg and CsA on TEN lesional and apparently uninvolved...

  • Demonstration of Clonal Immunoglobulin Gene Rearrangements in Cutaneous B-Cell Lymphomas and Pseudo--B-Cell Lymphomas: Differential Diagnostic and Pathogenetic Aspects. Rijlaarsdam, Udo; Bakels, Victor; van Oostveen, Johan W.; Gordijn, Roel J. L.; Geerts, Marie-Louise; Meijer, Chris J. L. M.; Willemze, Rein // Journal of Investigative Dermatology;Dec92, Vol. 99 Issue 6, p749 

    Twenty-five patients with a benign or malignant cutaneous B-cell lymphoproliferative disease, including seven cutaneous pseudo - B-cell lymphomas, eight primary cutaneous B-cell lymphomas (CBCL), and 10 secondary cutaneous B-cell lymphomas, were investigated for the presence of clonal...

  • Investigations of IgG4-related disease involving the skin. Yamada, Kazunori; Hamaguchi, Yasuhito; Saeki, Takako; Yagi, Kunimasa; Ito, Naoko; Kakuchi, Yasushi; Yamagishi, Masakazu; Takehara, Kazuhiko; Nakanuma, Yasuni; Kawano, Mitsuhiro // Modern Rheumatology (Springer Science & Business Media B.V.);Sep2013, Vol. 23 Issue 5, p986 

    Objectives: IgG4-related skin disease is not widely recognized. This prompted us to investigate the clinical and pathological features of five patients we encountered with IgG4-related disease (IgG4-RD) affecting the skin. Methods: We investigated the clinical and pathological features of these...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics