Efficacy of protective creams in a modified repeated irritation test: Methodological aspects

Wigger-Albert, Walter; Rougier, André; Richard, Alain; Elsner, Peter
July 1998
Acta Dermato-Venereologica;7/21/98, Vol. 78 Issue 4, p270
Academic Journal
The effect of 3 protective creams and petrolatum was tested in a repetitive irritation test. On 15 healthy volunteers, the irritants (sodium lauryl sulfate 10%, sodium hydroxide 0.5%, lactic acid 15%, and toluene undiluted) were applied on the paravertebral skin of the mid-back after 30 min pretreatment with the products tested. The volunteers were treated for 9 days. The irritant cutaneous reactions were quantified by erythema score, transepidermal water loss, and chromametry. The results showed a specific profile of efficacy against the 4 irritants used. For all creams a significant protective effect was obtained against irritation by sodium lauryl sulfate, sodium hydroxide and lactic acid in different degrees. Less efficacy was observed against toluene. Even an amplification of inflammation by pretreatment with 1 product could be demonstrated. The results indicate that a 1-week period of cumulative irritation might be enough to evaluate the efficacy of protective creams against most irritants.


Related Articles

  • `Flesh-eating bacteria'? Jain, Rupesh; Bredle, Donald L. // Physician & Sportsmedicine;Oct95, Vol. 23 Issue 10, p51 

    Presents the case of a 45-year-old male presenting with a tender, swollen erythematous nodule on the left forearm which intermittently drained pus. Physical examination findings; Discovery of foreign body in the nodule upon radiography; Differential diagnosis.

  • Rubbing out troublesome jock itch.  // Joe Weider's Muscle & Fitness;Apr94, Vol. 55 Issue 4, p52 

    Reports on the treatment for jock itch or tinea cruris. Symptoms; Etiology; Reduction of moisture and heat to prevent recurrence; Prevention; Over-the-counter medications.

  • Pet peeves.  // Executive Health's Good Health Report;Mar1994, Vol. 30 Issue 6, p8 

    Focuses on the correlation of skin infections with household pets that interact with humans. Parasitic insect bites; Secondary infections; Allergic skin reactions; Carriers of vial and bacterial infections.

  • At last! Keloids, blotches, scars need not be tolerated.  // New York Amsterdam News;8/03/96, Vol. 87 Issue 31, p17 

    Focuses on keloids, blotches and scars. Causes of the skin flaws; Remedies for the flaws; Recommended X-ray therapy for the flaws.

  • Main Ingredients.  // Global Cosmetic Industry;May2002, Vol. 170 Issue 5, p60 

    Focuses on the ingredients of cosmetic products. Effectivity of the sebum-regulating ingredient REGU-SEB on controlling oily skin; Benefit of petrolatum; Solubility of the silicone-based Silsoft A-553 conditioner.

  • Hot stuff! Petersen, Gerry // Drug Topics;1/1/2001, Vol. 145 Issue 1, p52 

    Presents a personal narrative about the purchasing of a petroleum jelly product.

  • petrolatum.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1762 

    A definition of the medical term "petrolatum" is presented, which refers to a mixture of hydrocarbons obtained from petroleum.

  • HANDS ON TIP. Ferguson, Carol // Equus;Sep2011, Issue 408, p16 

    The article suggests to apply petroleum jelly on the beams inside the barn in order to discourage sparrows from sitting and messing up the place.

  • MAKE FIRE IN A CAN. Freel, Tyler // Outdoor Life;Apr2014, Vol. 221 Issue 4, p44 

    The article offers tips on how to create a fire in a can using materials like fatwood and petroleum jelly and cotton balls.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics