TITLE

Effect of Long-term Use of Moisturizer on Skin Hydration, Barrier Function and Susceptibility to Irritants

AUTHOR(S)
Held, Elisabeth; Sveinsdóttir, Snjólaug; Agner, Tove
PUB. DATE
March 1999
SOURCE
Acta Dermato-Venereologica;03/18/99, Vol. 79 Issue 1, p49
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Moisturizers are often used in the prevention and treatment of irritant contact dermatitis. The present study was to determine whether long-term daily use of a moisturizer on normal skin would affect skin barrier function, hydration state, or susceptibility to sodium lauryl sulphate. Healthy volunteers used a moisturizer on one forearm 3 times daily for 4 weeks. The other forearm served as a control. Afterwards both forearms were challenged with a patch-test of sodium lauryl sulphate. Skin barrier function was evaluated by measuring trans-epidermal water loss and skin hydration by measuring electrical capacitance. Electrical capacitance was significantly increased on the treated arm during the treatment period. After challenge with sodium lauryl sulphate, trans-epidermal water loss was significantly higher on the arm treated with moisturizer than on the control arm. The results suggest that long-term treatment with moisturizers on normal skin may increase skin susceptibility to irritants.
ACCESSION #
4342550

 

Related Articles

  • Immediate Skin--Test Reactivity in a General Population Sample. Barbee, Robert A.; Lebowitz, Michael D.; Thompson, Hugh C.; Burrows, Benjamin // Annals of Internal Medicine;Feb76, Vol. 84 Issue 2, p129 

    Focuses on study which assessed the prevalence and distribution of allergic skin-test reactions in general population sample. Materials and methods; Measurable reactions in male subjects versus female subjects; Significance of prick test on atopy assessment.

  • Prick testing in chronic idiopathic urticaria: A report from a tertiary care centre in south India. Nath, Amiya Kumar; Adityan, Balaji; Thappa, Devinder Mohan // Internet Journal of Dermatology;2008, Vol. 6 Issue 2, p10 

    Background: Chronic idiopathic urticaria can be provoked by a number of known and unknown factors and allergens. Some of these allergens can be identified by prick tests. Objectives: To determine the frequency of chronic idiopathic urticaria and to identify the antigens showing positive...

  • Prevalencia de enfermedades alérgicas en adultos mayores. Ángeles, Martín Becerril; Vázquez Merino, Carlos L.; Garay, Ulises Ángeles; Alvarado Moctezuma, Luis E.; Guízar, Elena Vilchis // Revista Alergia de Mexico;may/jun2008, Vol. 55 Issue 3, p85 

    Background: A population aged 65 and over has been increasing in many countries, including Mexico. Allergic diseases are common in this age group, asthma prevalence has been reported between 2 and 17% in elderly people. There is no data about allergic diseases prevalence in elderly Mexican...

  • Defining Clinically Relevant Fragrance Allergens: The Challenge. Hostynek, Juri J.; Maibach, Howard I. // Cosmetics & Toiletries;May2007, Vol. 122 Issue 5, p42 

    The article discusses the challenges and criteria in identifying allergens that cause contact allergic dermatitis. It cites that the Excited Skin Syndrome can cause false positive reaction during a clinical patch test. It mentions the need to avoid irritation and active sensitization in order to...

  • Diagnóstico de la dermatitis de contacto. Prados, M.; Marquès, Ll. // El Farmacéutico Hospitales;dic2011, Issue 196, p13 

    The allergic contact dermatitis is treated by avoiding the allergen. For that reason it is necessary to know the allergens the cause the contact dermatitis by doing epicutaneous tests of retarded lecture. The practical aspects of this technique are discussed.

  • Markers of antioxidant defence system and lipid peroxidation in peripheral blood of female patients with chronic idiopathic urticaria. Kasperska-Zajac, Alicja; Brzoza, Zenon; Polaniak, Renata; Rogala, Barbara; Birkner, Ewa // Archives of Dermatological Research;Apr2007, Vol. 298 Issue 10, p499 

    Oxidative stress is an important event in lesional skin of patients with chronic idiopathic urticaria (CIU). In the present study, we assessed blood oxidant/antioxidant status of patients suffering from CIU with positive response to autologous serum skin test (ASST) and with negative ASST, to...

  • Cross-Reactivity and Tolerability of Cephalosporins in Patients with Immediate Hypersensitivity to Penicillins. Romano, Antonino; Guéant-rodriguez, Rosa-maria; Viola, Marinella; Pettinato, Rosa; Guéant, Jean-louis // Annals of Internal Medicine;7/6/2004, Vol. 141 Issue 1, p16 

    Background: In patients with documented IgE-mediated hypersensitivity to penicillins, data on sensitization to cephalosporins vary. Administering cephalosporins to such patients is often deferred because of the risk for cross-reactivity. Objective: To assess the cross-reactivity with...

  • Laser-Assisted Penetration of Allergens for Patch Testing. Veremis-Ley, Mary; Ramirez, Haydee; Baron, Elma; Hanneman, Kaija; Lankerani, Lela; Scull, Heather; Cooper, Kevin D.; Nedorost, Susan T. // Dermatitis (Decker Publishing);Mar2006, Vol. 17 Issue 1, p15 

    Background: Patch-test patients often complain of itching and inconvenience. Objective: To demonstrate (1) the usefulness of laser-assisted alteration of the stratum corneum to enhance allergen delivery and (2) patient satisfaction with this procedure. Methods: The LAD-01...

  • Pemphigus Foliaceus with Epidermal Detachment: Adverse Events from Patch Testing. Cocklin, Carrie L.; Shackelford, Krista; Wolverton, Stephen E.; Fett, Debra D. // Dermatitis (Decker Publishing);Mar2006, Vol. 17 Issue 1, p32 

    Uncommon adverse reactions to patch testing have been reported, but few cases have shown patch testing to be a potential contraindication. We report a patient with known pemphigus foliaceus who had significant epidermal detachment of normal skin during the removal of patch-testing tape.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics