In Vitro Release of Interferon-gamma and Macrophage Migration Inhibition Factor in Drug-induced Urticaria and Angioedema

Livni, Ella; Lapidoth, Moshe; Halevy, Sima
March 1999
Acta Dermato-Venereologica;03/18/99, Vol. 79 Issue 1, p18
Academic Journal
T-cells are involved in the pathogenesis of cutaneous drug reactions. T-cell phenotype and cytokine release pattern in vivo and in vitro might correlate with the type of immune response involved in cutaneous drug reactions. In vitro release of interferon-γ and macrophage migration inhibition factor (MIF) from peripheral blood lymphocytes, following in vitro challenge with the suspected unmodified drugs, was studied in 12 patients with drug-induced urticaria and/or angioedema and in two group-matched controls. The occurrence of positive interferon-γ and MIF responses was significantly higher in patients with drug-induced urticaria and/or angioedema than in controls. The sensitivity and specificity of the interferon-γ test (50% and 92%, respectively) were similar to that of the MIF test (58% and 96%, respectively). Percentage agreement between both tests was 80.9 (kappa = 0.76). In vitro release of interferon-γ and MIF in drug-induced urticaria and/or angioedema suggests a drug-specific immune response, and may implicate the drug as a possible inducer of the reaction.


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