Toward a magnetoresistive chip cytometer: Integrated detection of magnetic beads flowing at cm/s velocities in microfluidic channels

Loureiro, J.; Ferreira, R.; Cardoso, S.; Freitas, P. P.; Germano, J.; Fermon, C.; Arrias, G.; Pannetier-Lecoeur, M.; Rivadulla, F.; Rivas, J.
July 2009
Applied Physics Letters;7/20/2009, Vol. 95 Issue 3, p034104
Academic Journal
This work describes an integrated device comprising microfluidic channels and incorporated spin-valve sensors sensitive enough to count, determine the magnetic orientation, flowing height, and speed of single micron-sized magnetic beads moving with velocities of 8–35 mm/s. Sensor signals of 3–100 μVp-p correspond to bead moments at different directions indicating a physical rotation of the beads and a slow response (seconds) of the bead moment to magnetizing field changes.


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